1.Preventive and cure effects of guizhi fuling Pellet on rat hysteromyoma models
Li LI ; Guangliang CHENG ; Fangli GU ; Yuanshun WANG
Chinese Journal of Clinical Pharmacology and Therapeutics 2004;0(07):-
AIM: To study the preventive and cure effects of the guizhi fuling pellet (GFP) on rat hysteromyoma modes. METHODS: Estradiol (0.2) mg per rat was administrated by subcutaneous injection once a day to establish rat hysteromyoma model. (0.8) (mg?kg~(-1)) adrenalin was administrated by subcutaneous injection to establish rat blood stasis model. RESULTS: GFP((1.08)-(4.32) (g?kg~(-1)))remarkably decreased uterus weight, restrained the excess proliferation of the smooth muscle of uterus, decreased the estradiol and progesterone in blood serum, restrained the platelet aggregation, and it significantly decreased the blood viscosity, prolonged blood coagulation time, kaolin partly theroboplastin time and prothrombin time of rats. CONCLUSION: GFP can restrain the formation of hysteromyoma, and the mechanism of GFP is related to decreasing the estrogen and progesterone, activating blood circulation to dissipate blood stasis.
2.Septic patients caused by Vibrio vulnificus: epidemiology, clinical findings, diagnosis and treatment
Zhongqiu LU ; Caijiao LU ; Guangliang HONG ; Junyan CHENG ; Qiaomeng QIU ; Huan LIANG ; Bing WU ; Jingrong LI
Chinese Journal of Emergency Medicine 2009;18(7):732-736
Objective To study epidemiology, clinical findings, diagnosis and treatment of sepsis caused by Vibrio vulnificus. Method Patientss with Vibrio vulnificus sepsis were collected from 1995 to 2008. The medical records including epidemiological and clinical data were analyzed. Results The male-to-female ratio of 34cases was 4.7:1 and 76. 5% of these patients suffered from chronic liver disease. Most patients occurred from April to October with signs of abrupt fever, characteristic cutaneous lesions, hypotension and progressive multiple organ disfunction syndrome (MODS). The mortality was over 47.1% . The criteria proposed for early diagnosis of Vibrio vulnificus sepsis were abrupt onset with fever during the period from April to November, characteristic cutaneous lesions, such as the most commonly occurred haemorrhagic bullae on the extremities or even extensive necrosis of skin and muscular tissue, progressive hypotension or shock accompanied by MODS, pre-existing liver disease or chronic abuse of alcohol, and consumption of raw seafood or exposure to seawater within 12 week. Early administration of the third-generation cephalosporins with the quinolones in full dosage, aggressive wound debridement,appropriate dermoplasty and supportive care contribute to a better outcome. Conclusions Vibrio vulnificus sepsis progresses rapidly with high mortality. Early diagnosis, rapid treatment with prompt antibiotics and aggressive surgery treatment are very important to improve the outcome.
3.Discussion on the clinical treatment of infantile cerebral palsy with the differentiated intervention of meridian points on the spine and back.
Cheng ZHANG ; Xuefeng WANG ; Guangliang JIA ; Tian YANG
Chinese Acupuncture & Moxibustion 2017;37(9):1001-1004
In view of the literature study and clinical practice, the rules of the distribution, the general function and the indication of the meridians points on the spine and back were explored. The TCM mechanism on the rehabilitation of infantile cerebral palsy was studied. The rules of acupoint combination on the spine and back were summarized with meridians, main points and supplementary points involved in the TCM rehabilitation of infantile cerebral palsy. In view of the theoretic study, the advantages on the early infantile motor function, such as body turning, sitting, standing and walking, were analyzed with the long-term intervention of meridian points on the spine and back. It is showed in the rehabilitation of infantile cerebral palsy that the intervention of meridian points on the spine and back improves the motor function on the back and relieves the incoordination in the development between each system and enhances the rehabilitation mechanism of the integration of Chinese and western medicine for the functional development of core stability, which provides much more effective and more precise approach to the diagnosis and treatment of infantile cerebral palsy in clinical practice.