To investigate the level of serum IL-10 in allergic rhinitis patients and the correlation between IL-10 and serum total IgE (TIgE). 50 allergic rhinitis patients and 30 normal subjects were involved in the study. The levels of serum IL-10 and TIgE were measured by enzyme-linked immunosorbent assay (ELISA), and the correlation between serum IL-10 and TIgE was analyzed. In the allergic rhinitis group, the levels of serum IL-10 and TIgE were 8.34 +/- 2.48 pg/mL and 142.6 +/- 28.2 KU(A)/L. In the normal control group, they were 12.86 +/- 2.88 pg/mL and 47.2 +/- 12.2 KU(A). There were significant differences between the two groups (P < 0.01); and the level of serum TIgE in the patients was negatively correlated with that of IL-10 (r = -0.46, P = 0.02). The level of serum IL-10 was significantly decreased in allergic rhinitis patients, which was beneficial to the synthesization of IgE. IL-10 plays an important role in the episode of allergic rhinitis.
Enzyme-Linked Immunosorbent Assay ; Immunoglobulin E/*blood ; Interleukin-10/*blood ; Rhinitis, Allergic, Perennial/*blood

Hyperglycemia is considered to be a predictor of death, poor functional outcome, symptomatic intracerebral hemorrhage, and increased infarct volume in patients with acute ischemic stroke. Many studies have used parameters such as standard deviation, coefficient of variation, blood glucose level, stress hyperglycemia ratio, and glucose/glycated hemoglobin ratio to express hyperglycemia, and then study the relationship between hyperglycemia and stroke outcome. In patients with stroke receiving intravenous thrombolysis, hyperglycemia is closely associated with symptomatic intracerebral hemorrhage, poor neurological outcome, and lower vascular recanalization rate. In patients with stroke undergoing endovascular mechanical thrombectomy, hyperglycemia is closely associated with poor long-term outcome, increased mortality, and increased infarct volume. However, whether hyperglycemia will affect the effect of reperfusion therapy in acute ischemic stroke remains controversial. The possible mechanisms of hyperglycemia leading to poor outcomes after reperfusion therapy in patients with ischemic stroke include inhibition of vasodilation, reduction of plasma fibrinolytic activity, destruction of the blood-brain barrier, promotion of oxidative stress, and reduction of ischemic penumbra volume. Studies have shown that for stroke patients with hyperglycemia, intensive blood glucose control does not bring significant benefits. Therefore, the blood glucose control program of patients with acute ischemic stroke and hyperglycemia needs further study and discussion.

Objective To study the prognosis value of the expression of vascular endothelial growth factor and it's acceptor(VEGF,Flk-1) and microvessel density(MVD) gene proteins in the breast carcinoma and paracarcinoma tissue.Methods Immunohistochemical technique was adopted to detect the protein expression of VEGF,Flk-1 and MVD in 76 cases of breast carcinoma and 10 cases paracarcinoma tissue.Results (1)The positive expression of VEGF,Flk-1 were 59.3% and 61.3% in the carcinoma group,which were higher than in the paracarcinoma tissue(P

Objective To explore the relationship between platelet to lymphocyte ratio (PLR) and microangiopathyin type 2 diabetes mellitus. Methods In this case-control study, the clinical data on 428 adult patients with type 2 diabetic microangiopathy in our hospital from January 2009 to December 2015 were retrospectively analyzed. PLR, age, sex, fasting blood glucose, glycosylated hemoglobin, total cholesterol and triglyceride were tested to investigate their relationship with type 2 diabetic microangiopathy. Results Logistic regression analysis showed that PLR was a risk factor of type 2 diabetic microangiopathy (OR = 3.162, 95%CI:1.556 ~ 7.421, P < 0.05). Conclusions Greater PLR is closely related to type 2 diabetic microangiopathy, and we should pay attention to type 2 diabetic microangiopathy with a greater PLR in clinical practice.

0.05).Complications included 6 cases of delayed union,1 cases of severe elbow stiffness,3 cases of heterotopic ossification,2 cases of ulnar nerve palsy,in which one case recovered after 6 months,another case remained symptoms.[Conclusion]With appropriate training aids,the majority of patients have good effect.Same good clinical outcome have been achieved for treatment of intracondylar humeral fractures with either triceps splitting approach or the olecranon osteotomy approach.

Objective: To explore how the Chinese- English Bilinguals represent knowledge of the second language. Methods: The inter- language priming effects were investigated in two priming- category judgement tasks based individual- ly on the semantic (ExperimentⅠand ExperimentⅡ) and phonological information (ExperimentⅢ and ExperimentⅣ). Re- sults: In experimentⅠand ExperimentⅡ, no matter what the relation between the English targets and the English primes was semantic association or homophones and similar phones, the significant priming effects were obtained; However, In the experimentⅢ, when the relation between the targets and the primes was semantic association, no significant priming effect was found; In experimentⅣ, when the relation was homophones and similar phones, the significant priming effects were obtained. Conclusion: ①The second language knowledge of Chinese- English Bilinguals was represented in the semantic and phonological characters; ②The conceptual representation could be discreted with the lexical representation.

Objective To study the adverse effects of outdoor air pollution on children's respiratory system health in Anshan city. Methods 1951 children were randomly selected from three areas with different degree of air pollution in Anshan city. The parents of the children were asked to answer a questionnaire about their children's respiratory health and home environment. The data of health were collected included persistent cough, persistent phlegm, asthma, current asthma, wheeze, and wheeze symptom. Results The prevalence rates of persistent cough, persistent phlegm, asthma, current asthma, wheeze and wheeze symptom were 9.48%, 4.82%, 1.33%, 0.92%, 6.30% and 4.97% respectively. Outdoor air pollution was a risk factor for persistent cough and persistent phlegm. The respiratory symptoms increased as the house became near to the main traffic lines. Combined effect of susceptible factor and outdoor air pollution was obvious, the prevalence rates of respiratory diseases were higher in the susceptible children who were influenced by the other risk factors compared with those who were not influenced by the same factors. Conclusion Outdoor air pollution is an important factor which will damage children's respiratory system in Anshan city.

0.05).However,the difference between DIV and DV was statistically significant(P

0.05). Compared with the healthy neonates, the concentration of blood MDA and ROS was significantly higher, and that of blood HB and SOD was significantly lower in both groups(P

OBJECTIVETo assess the association between polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene C677T locus and nonsyndromic cleft lip with or without cleft palate (NSCL/P) in Shanxi Province of China.

METHODSBlood samples from 150 patients and their parents and 150 controls and their mothers were collected. The polymorphism of MTHFR gene C677T locus were analyzed by the methods of polymerase chain reaction and restriction fragment length polymorphism technique(PCR-RFLP). Case-control analysis, transmission-disequilibrium test(TDT) and haplotype-based haplotype relative risk analysis(HHRR) were used to study the correlation between the gene mutation and NSCL/P.

RESULTSHardy-Weinberg equilibrium test results showed that, the offspring and mother genotype in the case group and the control group was not deviated from the Hardy-Weinberg law of genetic equilibrium (P > 0.05). The distribution of genotype CC, CT and TT in offspring had significant difference between the two groups (P < 0.05). In the offspring and mother of case group and the control group, the carriers of the TT genotype compared to CC genotype, the OR are greater than 1 and 95% CI do not contain 1 (offspring OR: 2.692, 95% CI: 1.319-5.495; mother OR: 2.469, 95% CI: 1.136-5.363). The distribution of C allele and T mutation gene were significantly different in the offspring and mother between the two groups (P < 0.05). The TDT test showed: chi2 = 4.507, P < 0.05. The HHRR test showed: P < 0.05.

CONCLUSIONThe single nucleotide polymorphism of MTHFR C677T locus is associated with the development of NSCL/P in Shanxi Province.

Child ; Child, Preschool ; China ; Cleft Lip ; genetics ; Cleft Palate ; genetics ; Female ; Humans ; Infant ; Male ; Methylenetetrahydrofolate Reductase (NADPH2) ; genetics ; Polymorphism, Single Nucleotide