AIM: To investingate the variety of the function of vascular endothelium in the patients with hypertensive nephropathy and the effect of Huayu Qinli Granule on (Hirudo,Rhizoma Smilacis Glabrae,Herba Leonuri,etc.) it. METHODS: This was a prospective,comparative and single-blind clinical trial.Patients in accord with the diagnosis and TCM differentiation standard were randomly divided into treatment group,united treatment group,blank control group and positive control group.Before the beginning of the trial,all patients were treated by Felodipine to lower their blood pressure to desired value.When the trial began,blank control group were treated only by Felodipine, positive control group were treated by general hypertension pills+captopril,treatment group were treated by Felodipine+Huayu Qinli Granule,united treatment group were treated by Felodipine+Huayu Qinli Granule+captopril.The course of study was for 4 weeks.The levels of urinary microalbumine(ALB),urinary ?_1-microglobulin(?_1-mg),urinary?_2-microglobulin(?_2-mg),serum nitric oxide and plasma endothelin were measured before and after the trial. RESULTS: The results showed both Huayu Qinli Granule and ACEI improved the levels of serum nitric oxide but there was slightly advantage over ACEI;both Huayu Qinli Granule and ACEI improved the levels of plasma endothelin,the improvement of Huayu Qinli Granule was(equal) to ACEI;united treatment group had the remarkable effect on serum nitric oxide and plasma endothelin. CONCLUSION: The results indicate that Huayu Qinli Granule improves the function of vascular endothelium in the patients with hypertensive nephropathy to a certain extent with the sufficiency of the treatment of depressing blood pressure.The effect of Huayu Qinli Granule is similar to that of ACEI.They cooperate with each other but mechanism of them may be different.

Objective To evaluate the academic level and the popularity of Chinese Journal of Orthopaedics from the point view of citation. Methods According to the information of Chinese Medical Citation Index (CMCI), the amount and distribution of the original articles in Chinese Journal of Orthopaedics cited by the journals included by CMCI were statistically analyzed. The data analyzed included the percentage of cited articles, the number of citation of a single article, authors of most cited articles, geological regions of cited articles, years of citation, citing journals and self citing rate. Results The percentage of cited papers (749 articles, 4213 times) in all published 1184 articles in Chinese Journal of Orthopaedics from 2000 to 2004 were 76.43%, 75.20%, 71.49%, 57.46% and 30.19%, with an average of 63.26%. The original articles cited by other researchers were 7.86, 6.54, 5.48, 2.98 and 1.78, with an average of 5.62. The highest one was citated by 68 times. The most frequently cited authors were from 30 provinces of China and the city Beijing, Shanghai and Tianjin were the three topest cities among other cities in the naion. There were 461 citing journals, and there was 191 items self citsted, self-citing rate is 0.045. Conclusion Chinese Journal of Orthopaedics has published high quality articles. It has been become one of the most important information resource for orthopaedic researchers and one of the most important medical journals in China.

Objective To analyze the core authors, and their organizations, geographical regional distribution of Chinese Journal of Orthopaedics. Methods The core authors, coauthors and their organizations whose articles were published in Chinese Journal of Orthopaedics between 1995 and 2004 were quantitatively analyzed using literature search through CMCI, which programmed by the People's Liberation Army Medical Library and their geographical regions distribution, the organizations of whom had high quantitative publication were determined using literature metrology methods. Results There were 2660 articles published in Chinese Journal of Orthopaedics between 1995 and 2004. All of 1123 authors of 2660 articles had only one article published which accounted for 69.67% of total first authors on the Chinese Journal of Orthopaedics in ten years. There were 2385 articles with one or more coauthors and the cooperative rate was 89.66%, and cooperative degree was 4.11 in the period of time. There were 275 articles with single author, which accounted for 10.34% of total articles. The articles written by the authors from military hospitals, university affiliated hospitals and provinces-level hospitals were 646(24.28%), 1091(41.01%) and 706(26.54%), respectively during the period. There were 218 core authors with 959(36.05%) articles published and there were 20 high-quantities organizations with 1007(37.86%) articles published in this study. The number one region of published articles was Beijing with 667(25.08%) articles. There were 2443 (91.84%) articles pressed from the organizations of affiliated hospitals of universities, provinces-level hospitals and army hospitals. Among them, Tianjin hospital (101 articles), Beijing Jishuitan hospital (100 articles) and affiliated Xijing hospital of the 4th military medical mniversity (79 articles) occupied 10.53% of the pressed papers and they were in the first three positions. Conclusion Authors of Chinese Journal of Orthopaedics have a wide distribution and highly cooperative rate. There were a group of active and talented core authors who has a great influence on the journal.

Bibliometrics ; China ; Occupational Health ; statistics & numerical data ; Periodicals as Topic ; statistics & numerical data

AIM: To investigate the topography of the anterior surface of the human crystalline lens. ·METHODS: A Non-contact three-coodinate measuring system was utilized to scan the anterior surfaces of 8 human eye lenses in vitro. Acquired data were processed and computer models of the anterior lens surfaces were made using the program (Surfacer v 10.0). The to-pography of the anterior lens surfaces were established. Radii of curvature were measured at preset spots over the lens surfaces and two way analysis of variance was performed. The data were analysed to determine whether the radius of curvature varied systematically with the position on the lens surface from which the measurement was made. Lens surface asymmetric index (LSAI) was defined and calculated. The vertical and horizontal meridians of the modeled lens were calculated, and the best curve fit to any conic section was determined. ·RESULTS: The topography of the anterior lens surface indicated that the central zone (the central radius of curvature is (9.09±0.80)mm was steeper than that of the peripheral zone(17.05±2.20)mm. Two way analysis of variance of the radii of curvature at preset spots over the lens surfaces showed that the differences were statistically significant (P ＜ 0.05). Curve regression of radii of curvature at preset spots and their distances to the surface center revealed that the correlation of them was the third power function. LSAI increased steadily from the lens surface center(0.013±0.005) to the periphery(0.184± 0.065). The dots on the horizontal and vertical meridians were fit to four kinds of curves, and the determinate coefficient of hyperbola fit were the largest (0.9989-0.9999). ·CONCLUSION: The anterior lens surface is imperfectly rotational symmetric. Moreover, the nearer to the center, the more rotational symmetric it is. Radii of curvature increase nonlinearly from the surface center to the periphery. Anterior lens surface is typically hyperbolic.

Humans ; Musculoskeletal Diseases ; epidemiology ; prevention & control ; Occupational Diseases ; epidemiology ; prevention & control

Child, Preschool ; Foreign Bodies ; surgery ; Humans ; Male ; Rupture ; surgery ; Trachea ; surgery

Objective To investigate the effect of heat treatment on the proliferation of, melanin synthesis and tyrosinase activity in cultured normal human melanocytes. Methods Normal human foreskin tissue was obtained by sterile circumcision and melanocytes were harvested by using methods for epidermal cell culture. Basic fibroblast growth factor (bFGF) was utilized as the primary mitogen to establish the culture system of normal human epidermal melanocytes. Masson-Fontana staining was proformed to identify melanocytes.Third-passage melanocytes were treated with hyperthermia at various temperatures (39 ℃, 41 ℃, 42 ℃, 43 ℃ and 45℃) for 1 hour a day for consecutive 3 days followed by the measurement of cell viability with MTT assay. The hyperthermia at optimized temperature was used to treat fourth-passage melanocytes for 1 hour a day for consecutive 3 days; subsequently, the tyrosinase activity were detected with L-Dopa as the substrate, and melanin content was determined in heat-treated and untreated (control) melanocytes. Results The hyperthermia at 42 ℃ exhibited the strongest promotive effect on the proliferation of melanocytes among these 5 hyperthermia conditions. After treatment with hyperthermia at 42 ℃ for 1 hour a day for consecutive 3 days, melanocytes showed an increment in tyrosinase activity by 36.4% and melanin synthesis by 78% compared with the untreated melanocytes (both P＜0.05). Conclusions Heat treatment can enhance the proliferation of cultured human melanocytes, promote their melanin synthesis and tyrosinase activity.

Articulation Disorders ; surgery