0.05).Both of them had a linear correlativity,correlative coefficient closed to 1.Conclusions Coronary artery endothelial function and brachial artery endothelial function had a high linear correlativity.

To evaluate the left ventricular diastolic function with Doppler and 2D echocardiography in patients with mild and moderate hypertension. 202 patients with hypertension were involved in this study. The parameters of Doppler and 2D echocardiography were compared with clinical materials of the patients. The results of this study showed that age, diabetes, left ventricle hypertrophy and duration of hypertension were related to the left ventricular diastolic function, whereas hyperlipidmia, smoking and alcohol drink had less effect on left diastolic function. The results of this study suggested that there were diastolic dysfunction in patients with hypertension, and Doppler and 2D echocardiography could be used to detect left ventricular diastolic function.

Androgen receptors appear to play a significant role in the hepatocarcinogenesis.Androgen receptors are found to be expressed in liver tumor,and the overexpression of androgen receptor is associated with poor prognosis.Recent researches have indicated that androgen receptors regulate various cellular events in liver carcinogenesis through various ways,and androgen receptor could be a potential cancer therapeutic target in hepatocellular carcinoma.

Objective To assess the changes of the cardiac function of the patients with myocardial infarction(MI) after the coronary revascularization(CRV) by 2D echocardiography and Doppler tissue imaging(DTI).The effects of CRV on cardiac function were explored.Methods The global and regional wall functions were quantitatively analyzed in 49 patients with MI by 2D echocardiography and DTI(Aspen imaging systems).Results The regional function was improved prior to the global function in patients with MI after successful CRV.Conclusions CRV is one of the important factors for the cardiac function improvement in patients with MI.

The incidence of pancreatic neuroendocrine neoplasms is progressively growing.The clinical manifestation and treatment of this disease are complicated.Multi disciplinary combination therapy is needed to improve prognosis and life quality of patients.

Objective To evaluate the left ventricular systolic function of the patients who received coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI), in order to compare the clinical effectiveness of these two operations. Methods 61 patients with coronary artery disease were enrolled in this study. 28 patients received CABG and 33 patients PCI. The left ventricular systolic function was assessed by two-dimensional (2D) echocardiography and Doppler tissue imaging (DTI) (Aspen imaging systems). Results The left ventriculus ejection fraction (EF) and the average velocity of systolic wave (S) of mitral annular were increased after CABG or PCI. There was no statistical significant difference in degree of improvement in the left ventricular systolic function between two operations. Conclusions The results of this study suggested that the global left ventricular systolic function was improved after either successful CABG or PCI, with no signiticant difference in clinical efficaciousness.

Objective:To study the immune response to murine pancreatic carcinoma by bone marrow-derived dendritic cells(BM-DCs) modified with interleukin-23 after acquiring antigen from apoptotic pancreatic carcinoma cell.Methods:The murine IL-23 cDNA was sub-cloned into dual-expression vector.DCs were pulsed with apoptotic tumor cell antigen after transduced with interleukin-23 gene.The immune preventative and immunotherapeutic effects of DC vaccines on mice with pancreatic cancer were assessed.Results:IL-23 protein could apparently increase the antigen presenting ability of DC.After the vaccination of DC vaccines.IFN-? production in treatment group were significantly more than that of control group(P

Cell cycle-related kinase (CCRK) as a novel CDK-activating kinase plays a significant role in cell cycle regulation.Related studies confirm that CCRK is overexpressed in various tumors,and is associated with poor prognosis of the patients,which indicates that CCRK takes part in the generation and development of the tumor.

0.05). The incidence of anastomotic leakage in the control group (16.7%) was higher than that of the study group (4.3%). The area of collagen fibrils 3 d, 5 d and 7d after intestinal anastomosis in the study group were significantly more than that in the control group ( P

Objective:To investigate the antitumor efficiency of the special cytotoxic T lymphocytes(CTLs) activated by dendritic cells(DCs) pulsed with K-ras (12-Val) antigen.Methods:DCs was generated from PBMC in the presence of granuloceyte/macrophage-colony stimulating factor(GM-CSF),interleukin-4(IL-4)in vitro.DCs were differently sensitized with K-ras mutant pancreatic cancer cell line,K-ras(12-Val) mutant peptide,K-ras(12-Val) mutant peptide with the surface of cationic nanoparticle.Cell surface markers on DCs was measured by flow cytometry.The activation of CTL induced by DCs was detected by ~3H- thymidine incorporation test.The killing effects of CTL to pancreatic cancer was detected by ~(125)I-UdR release test. Production of IL-12 and IFN-γ by DCs and PBMC was detected by ELISA.Results:Compared with DCs pulsed with K-ras(12-Val) mutant peptide and K-ras (12-Val) mutant peptide with the surface of cationic nanoparticle,DCs pulsed with whole tumor antigen could better induce CTLs killing activity(P＜0.05).The DCs with K-ras(12-Val) mutant peptide and K-ras mutant peptide with the surface of cationic nanoparticle could produce specific CTL killing activity aganist pancreatic cancer cell line Patu8988(K-ras+)(P＜0.05),but not SW1990(K-ras-)(P＞0.05). K-ras (12-Val) mutant peptide with the surface of cationic nanoparticle at lower concentrations can be effectively presenting on the surface of DCs than only K-ras (12-Val) mutant peptide.Conclusion:K-ras (12-Val) mutant peptide with cationic carrier can be effectively presenting and expression of DCs and induce CTL specific killing activity aganist pancreatic cancer cell lines with K-ras (12-Val) mutant peptide.