Objective This study was designed to determine the serum CA-Hb 3 level in human colorectal carcinoma and analyze its clinical significance.Methods The level of serum CA-Hb 3 was measured by ELISA in 72 patients with colorectal carcinoma and 36 normal persons as the control group.Results The level of serum CA-Hb 3 in colorectal carcinoma was significantly higher than that of normal control .The level of serum CA-Hb 3 was positively related with tumor size,clinical pathological staging.With progression of clinical pathological staging (Dukes'stage),the level of CA-Hb 3 increased significantly,but its relation to tumor size,age,and sex was not significant.Conclusion Serum CA-Hb 3 assay may be a potentially valuable marker in assessment of pathological staging and judgement of clinical prognosis of colorectal carcinoma.

Objective The purpose of this study is to provide a reference for the selection of clinical radiotherapy plan by comparing the difference of dosimetry between coplanar dynamic intensity modulation dIMRT and coplanar VMAT plan in hippocampal protective whole brain radiotherapy (WBRT). Methods 10 patients were selected whose hippocampal were protected by WBRT, dIMRT and VMAT plans were designed for each patient, the differences of target dose, organ-endangering dose and machine hop count were compared between the two groups. Results The two technical plans PTV V_{30 Gy}, D_98% and D_2% all meet the standard of RTOG 0933, which is better than the dIMRT group for the PTV HI VMAT group (P = 0.004). The hippocampal dose of dIMRT group was better than that of VMAT group, but it did not meet the standard of RGOT 0933. The average D_max of hippocampus in dIMRT group and VMAT group was 18.44 Gy and 19.30 Gy, respectively (P = 0.004). The average value of hippocampal D_min was 10.03 Gy and 10.77 Gy, respectively (P = 0.013), and the mean value of hippocampal D_mean was 14.20 Gy and 15.12 Gy, respectively (P = 0.002). The doses of lens, eyeball and optic nerve all met the standard of RTOG0933, and the dose of dIMRT group was significantly better than that of VMAT group (P = 0.000). The treatment time in VMAT group was significantly lower than that in dIMRT group. The treatment time in VMAT group was significantly lower than that in dIMRT group. Conclusion Varian dIMRT has more advantages in controlling hippocampal dose and protecting lens than VMAT, but PTV HI and treatment efficiency are higher in VMAT group.