1.Granulocyte Colony-Stimulating Factor-Induced Psoriasiform Dermatitis Improved by Narrowband Ultraviolet B.
Min Soo JANG ; Jong Bin PARK ; Joon Hee KIM ; Myeong Hyeon YANG ; Kang Hoon LEE ; Sang Hwa HAN ; Kee Suck SUH
Annals of Dermatology 2017;29(2):232-233
No abstract available.
Dermatitis*
;
Granulocytes*
2.The effect of granulocyte colony stimulating facto(G-CSF) in a patient with propylthiouracil-induced agranulocytosis.
Kwang Hyen YOU ; Seung Si SON ; Seung Yel SONG ; Myoung Seon PARK ; Yong Gu LEE ; Chung Gu CHO
Journal of Korean Society of Endocrinology 1993;8(3):347-350
No abstract available.
Agranulocytosis*
;
Granulocytes*
;
Humans
3.To evaluate the efficacy of transfusion of white blood granulocyte mass for treating severe burn with bacterial infection and intoxication associated with leucopenia
Journal of Practical Medicine 2003;454(6):26-28
83 burn patients with the syndrome of bacterial infection and intoxication associated with leucopenia were divided in to 2 groups, the one of 32 patients without transfusion of white blood granulocyte, the other 51 patients with a transfusion rich with neutrophile leucocyte. Results: In the group of the syndrome of severe bacterial infection and intoxication associated with leucopenia, 39.2% have had complication, less than no transfusion group (68.7%). Mortality of the transfusion group: 82.4%, is higher than no transfusion group: 40.6%
Burns
;
Bacterial Infections
;
Granulocytes
4.Phase II clinical trial of recombinant human granulocyte colony-stimulating factor(fhG-CSF)(KRN8601) in advanced cancer patients with myelosuppression after chemotherapy.
Jae Kyung ROH ; Jin Hyuk CHOI ; Kyung Hee LEE ; Hye Ran LEE ; Nae Choon YOO ; Joo Hang KIM ; Byung Soo KIM ; Ho Young LIM
Journal of the Korean Cancer Association 1993;25(5):725-735
No abstract available.
Drug Therapy*
;
Granulocytes*
;
Humans*
5.Efficacy of recombinant human granulocyte colony-stimulating factor(neutrogin) for chemotherapy induced neutropenia in patients with advanced lung carcinoma.
Nae Choon YOO ; Joo Hang KIM ; Yi Young LEE ; Se Kyoo KIM ; Sung Kyoo KIM ; Won Young LEE ; Bong Soo CHA ; Jin Hyuk CHOI ; Ho Young LIM ; Jae Kyung ROH ; Byung Soo KIM
Journal of the Korean Cancer Association 1993;25(2):236-246
No abstract available.
Drug Therapy*
;
Granulocytes*
;
Humans*
;
Lung*
;
Neutropenia*
6.Unusual Morphology of Eosinophil Nucleus: Presented with Double Chromatin Filament Bridge: Report of Three Cases.
Ae Seek KIM ; Young Hee KONG ; Ji Youn KIM
Korean Journal of Clinical Pathology 1998;18(2):122-125
We found an unusual morphology of eosinophil nucleus having longer chromatin filament in addition to a single narrow chromatin bridge. The nucleus having two chromatin filament bridge looked like two legged eosinophil, instead of usual glasses shape. As the physiologic function of the nucleus of granulocyte segmentation and the mechanism by which the lobes are formed during differention is still unknown, we could not know the definite nature and significance of these double chromatin filament. However we could suggest that they may be a reactive change of eosinophilia. This not uncommon morphology has not been described as yet. Here we report three cases of unusual morphology of eosinophil nucleus presenting double chromatin filament bridge, one case with a band form nucleus looked like ring shape, with brief review of literatures.
Chromatin*
;
Eosinophilia
;
Eosinophils*
;
Eyeglasses
;
Glass
;
Granulocytes
;
Leg
7.Two cases of congenital agranulocytosis treated with recombinant human granulocyte colony-stimulating factor.
Byoung Ho CHA ; Seung Hwan OH ; Chukl Joo LYU ; Chang Hyun YANG ; Kir Young KIM
Korean Journal of Hematology 1992;27(2):325-329
No abstract available.
Agranulocytosis*
;
Granulocyte Colony-Stimulating Factor*
;
Granulocytes*
;
Humans*
8.Late Onset Agranulocytosis with Clozapine Associated with HLA DR4 Responding to Treatment with Granulocyte Colony-stimulating Factor: A Case Report and Review of Literature.
Aakanksha SINGH ; Sandeep GROVER ; Pankaj MALHOTRA ; Subhash C VARMA
Clinical Psychopharmacology and Neuroscience 2016;14(2):212-217
Agranulocytosis as a side effect of clozapine has been reported to be associated with initial phases of treatment, i.e., first six months. Agranulocytosis with clozapine during the initial phases of treatment has been linked to genetic vulnerability in the form of variations in the human leukocyte-antigen haplotypes. However, there is limited literature on late onset agranulocytosis with clozapine and this has very rarely been linked to human leukocyte-antigen haplotypes vulnerability. In this report we review the existing data on late onset agranulocytosis with clozapine and describe the case of a young man, who developed agranulocytosis with clozapine after 35 months of treatment and was found to have genetic vulnerability in form of being positive for HLA DR4. This case highlights underlying autoimmune immune mechanism in clozapine-induced agranulocytosis and the need for frequent blood count monitoring on clozapine even after the initial 6 months of starting treatment especially in patients with genetic vulnerability to develop this condition.
Agranulocytosis*
;
Clozapine*
;
Granulocyte Colony-Stimulating Factor*
;
Granulocytes*
;
Haplotypes
;
Humans
;
Neutropenia
9.Sysmex SE-000: Evaluation on the Morphologic Flags and Determination of the Review Criteria.
Seok Lae CHAE ; Jang Soon PARK ; Dae Chul KIM ; Sung Won KIM ; Young Joo CHA
Korean Journal of Clinical Pathology 2000;20(5):449-454
BACKGROUND: We evaluated the performance of leukocyte differential counting and clinical usefulness of the morphologic flags of the SE-000, and set optimal criteria for selecting and reviewing the specimens with increased abnormal cells. METHODS: From the results of SE-000 and manual leukocyte differential counting in 100 healthy control and 520 patient specimens we evaluated the correlations on the leukocyte fractions as well as the frequency, sensitivity and false positivity of the flags. After determination of the review criteria we calculated total review rate from the 3,403 consecutive CBC specimens. RESULTS: In both control and patient groups the correlation between two methods was high with the exception of monocytes and basophils. Regarding the morphologic flags, Blast was sensitive (86.9%) however could not detect mature looking lymphoblasts. Immature granulocyte showed high sensitivity (93.7%). Left shift showed the highest frequency (34.6%) and false positive rate (82.8%). Atypical lymphocytes and NRBC showed relatively low sensitivity (63.6%, and 50.5%, respectively). We determined to review the slide when 1) All morphologic flags except Left shift are marked, 2) WBC <3,000/microliter or >20,000/microliter, Hb <8.0 g/dL or 18.0 g/dL, Platelet <100,000/microliter or >600,000/microliter, 3) Severe deviation of leukocyte fractions or 4) Specially requested by physician. As a result, total review rate was 25.0% while 14 abnormal cases with no flags could be additionally detected. CONCLUSIONS: A new review criteria determined from the results of CBC and leukocyte differential together with morphologic flags could reduce the review rate without skipping the abnormal cases.
Basophils
;
Blood Platelets
;
Granulocytes
;
Humans
;
Leukocytes
;
Lymphocytes
;
Monocytes
10.Sysmex SE-000: Evaluation on the Morphologic Flags and Determination of the Review Criteria.
Seok Lae CHAE ; Jang Soon PARK ; Dae Chul KIM ; Sung Won KIM ; Young Joo CHA
Korean Journal of Clinical Pathology 2000;20(5):449-454
BACKGROUND: We evaluated the performance of leukocyte differential counting and clinical usefulness of the morphologic flags of the SE-000, and set optimal criteria for selecting and reviewing the specimens with increased abnormal cells. METHODS: From the results of SE-000 and manual leukocyte differential counting in 100 healthy control and 520 patient specimens we evaluated the correlations on the leukocyte fractions as well as the frequency, sensitivity and false positivity of the flags. After determination of the review criteria we calculated total review rate from the 3,403 consecutive CBC specimens. RESULTS: In both control and patient groups the correlation between two methods was high with the exception of monocytes and basophils. Regarding the morphologic flags, Blast was sensitive (86.9%) however could not detect mature looking lymphoblasts. Immature granulocyte showed high sensitivity (93.7%). Left shift showed the highest frequency (34.6%) and false positive rate (82.8%). Atypical lymphocytes and NRBC showed relatively low sensitivity (63.6%, and 50.5%, respectively). We determined to review the slide when 1) All morphologic flags except Left shift are marked, 2) WBC <3,000/microliter or >20,000/microliter, Hb <8.0 g/dL or 18.0 g/dL, Platelet <100,000/microliter or >600,000/microliter, 3) Severe deviation of leukocyte fractions or 4) Specially requested by physician. As a result, total review rate was 25.0% while 14 abnormal cases with no flags could be additionally detected. CONCLUSIONS: A new review criteria determined from the results of CBC and leukocyte differential together with morphologic flags could reduce the review rate without skipping the abnormal cases.
Basophils
;
Blood Platelets
;
Granulocytes
;
Humans
;
Leukocytes
;
Lymphocytes
;
Monocytes