Introduction: Porphyromonas gingivalis adhesion to neutrophils is an important initial process in periodontal disease. The process of bacterial adhesion must be inhibited so that periodontal disease does not develop into severe. Graptophyllum pictum contains several active substances that can affect the function of neutrophils. Aim of the research to find out the inhibition of Graptophyllum pictum leaf extracts (GLE) in various concentrations against the adhesion of Porphyromonas gingivalis to neutrophils. Methods: The method used is experimental laboratory using the post test only control group design. This research used a sample of isolate neutrophils taken from the blood of subjects with inclusion criteria. The sample was divided into 5 groups: the control group (without GLE), GLE 3.125%, GLE 6.25%, GLE 12.5%, and GLE 25%.The neutrophils isolate was incubated with GLE for 3 hours, then exposed to Porphyromonas gingivalis for 8 hours. The adhesion index is calculated by the average number of Porphyromonas gingivalis attached to 100 neutrophils. Results: Based on these results can be interpreted that GLE 3.125%, GLE 6.25% and GLE 12.5% showed no significant difference, in the mean those concentrations doesn’t have ability to inhibit the adhesion of Porphyromonas gingivalis in neutrophils. So GLE 25% only which is able to inhibit the adhesion of Porphyromonas gingivalis in neutrophils. Conclusion: GLE can inhibit the adhesion of Porphyromonas gingivalis to neutrophils by GLE 25% effectively only.