1.Meta-analysis of the efficacy and safety of tranexamic acid for hemostasis in cancer patients before and during surgery
Huihong QI ; Zhijun CHU ; Lianhao FU ; Wanli JIAO
China Pharmacy 2023;34(14):1755-1760
OBJECTIVE To systematically review the efficacy and safety of tranexamic acid (TXA) for hemostasis in cancer patients before and during surgery, and to provide evidence-based reference for clinical drug use. METHODS Retrieved from PubMed, Embase, the Cochrane Library, CNKI, VIP and Wanfang databases, randomized controlled trials (RCTs) about tranexamic acid (trial group) versus 0.9% Sodium chloride injection, Lactated Ringer’s solution, Compound electrolyte solution or placebo (control group) for cancer surgery were electronically searched from the inception to June 9, 2022. After literature screening and data extraction, the quality of included RCTs were evaluated by bias risk assessment tool recommended by Cochrane system evaluator manual 5.1.0. RevMan 5.3 software was used for meta-analysis or descriptive analysis, sensitivity analysis and publication bias analysis. RESULTS A total of 2 032 patients in 22 RCTs were included for meta-analysis. Results of meta-analysis showed that the blood transfusion rate [RR=0.59, 95%CI (0.50, 0.69), P<0.000 01] and the volume of erythrocyte suspension infusion [MD=-0.53, 95%CI (-0.92, -0.14), P=0.007] in trial group were significantly lower than control group; there was no statistical significance in the incidence of thromboembolic events [RR=0.44, 95%CI (0.16, 1.17), P=0.10] or post-operative mortality [RR=1.27, 95%CI(0.32,5.08), P=0.73] between two groups. Results of descriptive analysis showed that the total blood loss and postoperative drainage volume were still controversial between two groups. The results of sensitivity analysis showed that the results were basically stable. The results of publication bias analysis showed that there was little possibility of publication bias in this study. CONCLUSIONS TXA can significantly decrease the blood transfusion, reduce the volume of erythrocyte suspension infusion, whereas does not increase the incidence of thromboembolic events and post-operative mortality in cancer surgery.
2.DIAGNOSIS AND TREATMENT OF CYSTICERCOSIS OF CEREBRAL VENTRICLES
Yongfu ZHANG ; Hongwei LI ; Wencheng HUANG ; Gongren CHU ; Xiwen SHI ; Dali YIN ; Jiadong ZHANG ; Xihong WANG ; Binli ZHOU ; Dong ZHAO
Chinese Journal of Parasitology and Parasitic Diseases 1987;0(04):-
31 patients with cysticercosis of cerebral ventricles verified by operation or pathological investigation were reported. All patients were between 7 and 64 years of age and 14 were females. All had a single cyst. Since 29 patients (94%) were without a history of intestinal taeniasis, it was proposed that most patients of cysticercosis of cerebral ventricles were caused by hetero-infection and the entrance of Cysticercus into brain ventricle was through choroid plexus along the cerebro-spinal fluid. This is probably the reason why it occurs mostly in the 4th ventricle. The clinical manifestation of cysticercosis of cerebral ventricles were paroxysmal headache and vomiting caused by increased intracranial pressure. Ventricu-lography and CT scanning have considerable diagnostic value. Removal of Cysticercus by surgical operation is successful (Figs. 1 - 8).