At the Hospital number 108, in the Department of Dermato-Venerology, an investigation was performed on 58 patients with psoriasis at the progressive stage in order to determine the change of peripheri blood globuline and clinical features of the disease. The quantification of globuline showed that IgA and IgG levels decreased but normal level did not still reestablished. The variations of IgM were not significant. Between IgA and IgG levels, there was a positive and closed relation. IgA and IgG level increased early, immediately in the mild level of the disease and in the recessive stage of the disease at three levels, they were also higher than that of the control group; particulally, IgA in severe level did not drop down even when the disease was recessive. IgM levels were not changed in any levels of the severity.
Psoriasis ; Globulins ; Blood

The research studied urinary beta2-microglobulin excretion to detect tubular dysfunction in 31 patients with primary nephrotic syndrome. The result showed the increased excretion of beta2-microglobulin was observed in 11/31 cases. There were no sighgicant differences of the urinary creatinine excreation and between group of patients with increased urinary beta2-microglobulin excretion and the group without it. This indicated having combine tubular dysfunction in patients with primary nephrotic syndrome. The finding might suggest the use of urinary beta2-microglobulin for detecting the associated tubular disfuntion in such patients
Diagnosis ; Creatinine ; Beta-Globulins

Analysis of synovial fluid is a most helpful aid in diagnosis and differentiating the varlous types of arthritis. But little information is available on joint fluid proteins and immunoglobullns. The present study was designed to obtain more precise information about each component of joint fluid proteins, using Acrylamide Gel Microzone system with a Densitometer. The following results were obtained: 1. The amount of total protein in both types of arthritis was approximately twice as high as that in the normal group (Normal;2.12± 0.50g%, R.A.;4.51± 1.18g%, Tbc;4.10± 1.02g%). 2. The albumin fraction was decreased in both types of arthrltis (R.A.;42.15± 5.21g%, Tbc; 44.24± 5.61g%) in comparison with 65.25± 4.40g% in the normal group. 3. The percentages of Alpha 1 and Beta globulin in both types of arthritis were similar to that in the normal group. (Normal:Alpha 1;6.01± 1.10, beta; 12.40± 1.90) 4. The percentages of Alpha 2 globulin and gamma globulin in both types of arthritis were approximately twice as high as that in the normal group. (Normal:Alpha 2;5.31± 1.62, Gamrna; 11.03± 1.51).
Acrylamide ; Arthritis ; Beta-Globulins ; Diagnosis ; gamma-Globulins ; Joints ; Synovial Fluid

No abstract available.
gamma-Globulins* ; Purpura, Thrombocytopenic, Idiopathic*

No abstract available.
Aspirin* ; gamma-Globulins* ; Mucocutaneous Lymph Node Syndrome*

OBJECTIVEWe detected and analyzed the clinical values of total protein (TP), albumin (ALB), globulin (GLB), and ALB/GLB ratio (A/G) of whole unstimulated saliva of healthy people to determine the time of day when saliva composition is relatively stable. We compared the protein concentration and A/G of whole unstimulated saliva of patients with chronic periodontitis with those of healthy volunteers to provide references for diagnostic methods and clinical applications of saliva.

METHODSThe whole saliva of 37 healthy subjects were collected at 8:00, 9:30, 11:30, 13:00, 16:30, and 21:00. Meanwhile, the whole saliva of 24 patients with periodontitis was collected in the morning. Bicinchoninic acid method was used to detect the TP content. Saliva ALB was detected by GF-D800 semi-automatic biochemical analyzer, and the GLB and A/G were calculated. Finally, the results were statistically analyzed using SPSS 19.0.

RESULTSSalivary protein compositions were stable in the morning on an empty stomach. Healthy people: TP, (1 354.35±389.52) µg.mL-1; ALB, (139.55±27.19) µg.mL-1; GLB, (1 211.80±360.73) µg.mL-1; A/G, 0.126 3±0.041 7. Subjects with chronic periodontitis: TP, (2 611.56±231.62) µg.mL-1; ALB, (296.27±17.34) µg.mL-1; GLB, (2 315.69±221.67) µg.mL-1; A/G, 0.156 2±0.017 3. The contents of TP, ALB, and GLB in healthy individuals at different periods within a day showed significant differences (P<0.05), which were mainly reflected in the levels before and after meals. No significant difference was detected in A/G. The concentrations of TP, ALB, and GLB were significantly increased in patients with chronic periodontitis compared with those in healthy volunteers. However, no significant difference existed in A/G.

CONCLUSIONSalivary protein compositions are more stable in the morning than in other periods. Thus, mornings can be set as the time of specimen collection in future research. The concentrations of TP, ALB, and GLB in patients with chronic periodontitis are higher than those in healthy people.

The concentrations of serum proteins fractions and their electrophoretical patterns were investigated in 135 patients with coal workers' pneumoconiosis who participated in confirmative examination for pneumoconiosis in December 1989. Their radiographical profusions were classified as 1/0 or more. Agarose film and phosphoric acid-sodium hydroxide buffer(pH 8.6) were used for electrophoresis. Concentration of each protein fractions and electrophoretical patterns seemed to be equivalent to reference values. Serum alpah1- and beta-globulin concentrations, however, were significantly different(p<0.50) among categories of small opacity profusions and showed the lowest level in the group of category 1. Albumin concentrations decreased and alpha2-globulin concentrations increased significantly(p<0.05) in the group of complicated with pulmonary tuberculosis. gamma-globulin concentrations were not varied by category of profusions nor by pulmonary tuberculosis complication.
Beta-Globulins ; Blood Proteins ; Coal* ; Electrophoresis ; gamma-Globulins ; Humans ; Pneumoconiosis* ; Reference Values ; Sepharose ; Tuberculosis, Pulmonary

Protein levels were measured in 91 cases with acute glomerulonephritis from 2 years to 15 years of age. Measurements were made using microzone electrophoresis on cellulose acetate. A unique and somewhat characteristic pattern was obtained in all our patients with acute glomerulonephritis. The mean values of the total serum protein were significantly decreased, except in the age group of 23 years, with acute glomerulonephritis as compared with the normal values of the total serum protein. The mean levels of albumin were also decreased with statistical significance in all our patients. On the whole, the levels for the alpha-1 and alpha-2 globulins tended to be somewhat higher in patients with acute glomerulonephritis than in the healthy children. But there were no significant differences among them. In the beta fraction, the mean levels with acute glomerulonephritis were decreased with ststistical significance except in the age group of 23 years. In the gamma fraction, the mean levels with acute glomerulonephritis were markedly increased as compared with the mean values of the healthy children. To summarize, the most striking changes in the patients with acute glomerulonephritis consisted mainly of a moderate reduction of the total protein and albumin, a decrease in the beta fraction and an increase in the gamma globulin. None showed a significant increase in the alpha-1 and the alpha-2 fraction.
Cellulose* ; Child ; Electrophoresis* ; gamma-Globulins ; Globulins ; Glomerulonephritis* ; Humans ; Reference Values ; Strikes, Employee

A Clinical observation on 272 cases of epidemic encephalitis admitted to the Department of Pediatrics, Chonnam University Hospital with 5 year duration from 1971 to 1975 was carried out and the serum protein fractions were studied paperelectrophoretically on 28 cases in 1975 The following results are obtained. : 1) The peak age group was from 6 to 10 years old, and the male to female ratio was 1.7:1 2) The complaints on admission were fever(100%), neck stiffness(78.3%), Kernig's sign(71.7%), vomiting(64.0%), unconsciousness(59.6%), and headache(57.4%), in order of frequency. 3) Laboratory findings were as follows ; In the most cases(79.4%), peripheral leukocytosis with increased polymorphocyte was noted. And the findings of C.S.F. showed; Pleocytosis (98.5%), increased protein content(90.1%), normal or slightly increased sugar content(97.8%) and within normal limits of chloride level. 4) Mortality rate was 20.2% 5) The total protein and beta-globulin level showed no change and decreased albumin and A/G ratio. The gamma-globulin level showed increased initially and thereafter decreased to normlal limits gradually.
Beta-Globulins ; Child ; Encephalitis, Arbovirus* ; Female ; gamma-Globulins ; Humans ; Jeollanam-do ; Leukocytosis ; Male ; Mortality ; Neck ; Pediatrics

Many reports have been found in the literature regarding the electrophoretic study of various urogenital diseases, but those on syphilis are relatively rare. It is author's opinion that the correlation between syphilis and the dysfunction of various organs must also be elucidated into detail. On this view point the author has studied the total protein and paper electrophoretic fractions of the serum derived from the patients of syphilis in 17 males and 5 females visited our department during the period from October, 1962 to September, 1964 Age distribution was between 18 and 45 years of age and duration of history was from 3 months to 8 months. The results obtained were as follows: 1. Total protein and electrophoretic fractions of 22 patients' serum: a) The amount of total protein decreased slightly. b) Albumin decreased markedly. c) Alpha 1 globulin decreased remarkably. d) Alpha 2 globulin decreased slightly. e) Beta globulin increased very remarkably. f) Gamma globulin increased markedly. g) A/G ratio decreased very remarkably. All of the above patterns were compared with normal rate. 2. Total protein and electrophoretic fractions of same 22 patients' serum in duration 30 days after complete therapy: a) The amount of total protein, albumin alpha 2 globulin, gamma globulin and A/G ratio etc. are unchanged b) Alpha 1 globulin decreased markedly. c) Beta globulin increased slightly. All of the above pattern were compared with normal rate.
Age Distribution ; Beta-Globulins ; Electrophoresis, Paper ; Female ; gamma-Globulins ; Humans ; Male ; Syphilis