Background& Objective: Temporal lobe epilepsy has been associatedwith psychopathology especially obsessive-compulsive (OC) traits or symptoms as one of it’s specific personality characteristics as compared to other epilepsies. This study was undertaken to assess the prevalence and type of OC symptoms in patients with complex partial seizures (CPS) and generalized seizure disorders and the association of OC symptoms with right or left sided lesions in patients with CPS. Methods: Thirty patients each of CPS and generalized seizure disorder were enrolled to study OC symptoms with the help of the Padua Inventory, a 39 item measure of obsessions and compulsions on 5 content areas relevant to obsessive compulsive disorder. A proforma was prepared to study the various demographic variables, details of seizure disorder and MRI findings. Results: Ninety three per cent of CPS patients had OC symptoms as compared to 40% generalized seizure patients which was statistically significant. Dressing and grooming compulsions, contamination obsessions and washing compulsions were predominant in both the groups. On all the domains of the Padua Inventory, the CPS patients had statistically significant dysfunction than the generalized seizure patients. A highly significant association between left sided temporal lobe sclerosis for obsessions of contamination and washing as well as dressing and grooming was seen in the CPS patients. Conclusions: Involvement of different brain structures in different epileptic syndromes, plays a role in the susceptibility to develop specific psychopathological disorders like OC symptoms or obsessive compulsive disorder which are seen more in CPS as compared to generalized seizures.
Epilepsy

Idiopathic osteoarthritis of the hip has been currently attributed by researchers to the repetitive microtrauma caused to the femoral neck by its impingement against the acetabular rim. This impingement occurs as a result of abnormal morphological traits like Allen’s fossa, Poirier’s Facet, and Posterior Cervical Imprint that appear on the proximal end of femur especially on the neck. Hence, this study was undertaken to investigate the incidence of these traits in the Indian population and to find a correlation between the occurrence of the trait and the side and sex of the bone. The study was conducted on 152 adult dried femora in the Department of Anatomy, Maulana Azad Medical College, New Delhi, India. The positive findings were photographed. The significance of the correlation was found out using Chi-square test. Allen’s Fossa was found to occur in 71.1% of the total bones assessed Poirier’s Facet in 31.6% and Posterior Cervical Imprint in 19.7%. Out of these, a significant side association was found for the Poirier’s Facet with a predominance of the left side. All the traits were found to be more in males with a significant sex variation for Poirier’s Facet. Each trait demonstrated a significant side and gender dimorphism.

As per the report published by FAO (2004), the tick population in India has developed resistance against all the available acaricides. Hence, newer methods of control including potential herbal agents are required to reduce the problems caused by the ticks. Most of the herbal extracts or their fractions are dissolved in polar or non-polar solvents or detergents before tested for acaricidal activity and these diluents should be of little acaricidal activity. In the present study, adult immersion test (AIT) was carried out on adult engorged female Haemaphysalis bispinosa ticks to detect the acaricidal activity of different solvents viz., nbutanol, glycerol, acetone, ethanol, methanol and surfactants (at 1 per cent dilution) like dimethyl sulphoxide (DMSO), tween 20 and triton X- 100. The study revealed that methanol was the least toxic solvent while tween 20 (1 per cent) was the least toxic detergent against H. bispinosa.

The ovary of Haemaphysalis bispinosa was of panoistic type with asynchronous development of oocytes. The wall of the ovary was composed of a layer of epithelial cells to which the oocytes were attached by means of pedicel cells with elongated nucleus. The oocytes were classified into stages I to V based on morphologic characteristics like size and shape, presence / absence of germ vesicle, cytoplasmic appearance, presence or absence of yolk granules and presence of chorion. Day wise changes were in the form of occurrence of oogonia from partially fed upto day zero of engorgement, presence of all stages of oocytes on day one and two after engorgement and onset of degenerative changes in oocytes from day three onwards. Degeneration was complete on day eight with the appearance of polymorphism, vacuolation, cytoplasmic blebbing and autophagic activity in oocytes.

Carotid body tumor excision can lead to various complications including vascular injury and pseudoaneurysm formation. Here we describe a case of carotid body tumor excision followed by series of complications including pseudoaneurysm formation, failure of primary surgical repair, carotid stump syndrome following parent artery occlusion, and persistent hypotension.

The animal model deals with the species other than the human, as it can imitate the disease progression, its’ diagnosis as well as a treatment similar to human. Discovery of a drug and/or component, equipment, their toxicological studies, dose, side effects are in vivo studied for future use in humans considering its’ ethical issues. Here lies the importance of the animal model for its enormous use in biomedical research. Animal models have many facets that mimic various disease conditions in humans like systemic autoimmune diseases, rheumatoid arthritis, epilepsy, Alzheimer’s disease, cardiovascular diseases, Atherosclerosis, diabetes, etc., and many more. Besides, the model has tremendous importance in drug development, development of medical devices, tissue engineering, wound healing, and bone and cartilage regeneration studies, as a model in vascular surgeries as well as the model for vertebral disc regeneration surgery. Though, all the models have some advantages as well as challenges, but, present review has emphasized the importance of various small and large animal models in pharmaceutical drug development, transgenic animal models, models for medical device developments, studies for various human diseases, bone and cartilage regeneration model, diabetic and burn wound model as well as surgical models like vascular surgeries and surgeries for intervertebral disc degeneration considering all the ethical issues of that specific animal model. Despite, the process of using the animal model has facilitated researchers to carry out the researches that would have been impossible to accomplish in human considering the ethical prohibitions.

Unilateral adrenalectomy was performed in six black Bengal goat (Capra hircus)to study electrocardiograph in connection with mineral metabolism with special reference to sodium and potassium and some other factors of physiological importance. The parameters were studied at every 12 hrs interval upto 120 hrs and 24 hrs interval from 120 to 240 hrs.Physiological parameters, like body weight and rectal temperature, changed non-significantly (p<0.05)after adrenalectomy. Among minerals, plasma sodium (p<0.01)and plasma potassium (p<0.05) concentration were changed significantly between hours leaving impression in ECG as widening of QRS complex and peaked T wave with increased amplitude found after unilateral adrenalectomy. Heart rate also increased significantly (p<0.01)between hours.
*Adrenalectomy ; Animals ; Body Temperature ; Body Weight ; *Electrocardiography/adverse effects ; Female ; Goats ; Heart Rate ; Potassium/*metabolism ; Sodium/*metabolism

Rotavirus (RV)-infected piglets are presumed to be latent sources of heterologous RV infection in humans and other animals. In RVs, non-structural protein 4 (NSP4) is the major virulence factor with pleiotropic properties. In this study, we analyzed the nsp4 gene from porcine RVs isolated from diarrheic and non-diarrheic cases at different levels of protein folding to explore correlations to diarrhea-inducing capabilities and evolution of nsp4 in the porcine population. Full-length nsp4 genes were amplified, cloned, sequenced, and then analyzed for antigenic epitopes, RotaC classification, homology, genetic relationship, modeling of NSP4 protein, and prediction of post-translational modification. RV presence was observed in both diarrheic and non-diarrheic piglets. All nsp4 genes possessed the E1 genotype. Comparison of primary, secondary, and tertiary structure and the prediction of post-translational modifications of NSP4 from diarrheic and non-diarrheic piglets revealed no apparent differences. Sequence analysis indicated that nsp4 genes have a multi-phyletic evolutionary origin and exhibit species independent genetic diversity. The results emphasize the evolution of the E9 nsp4 genotype from the E1 genotype and suggest that the diarrhea-inducing capability of porcine RVs may not be exclusively linked to its enterotoxin gene.
Animals ; Classification ; Clone Cells ; Enterotoxins ; Epitopes ; Genetic Variation ; Genotype ; Humans ; Protein Folding ; Protein Processing, Post-Translational ; Rotavirus ; Sequence Analysis ; Viral Nonstructural Proteins ; Virulence