1. Malnutrition in the critically ill child
Enkhtsolmon S ; Bayarmaa N ; Malchinkhuu D ; Batsolongo R ; Erdenechimeg T ; Enkhtaivan B ; Gereltuya B
Innovation 2015;9(4):62-64
Children under 5 years of age in developing countries are particularly vulnerable to malnutrition. Malnutrition affects 50% of hospitalized children and 25–70% of the critically ill children. Malnutrition interferes with the appropriate response of the body to disease and predisposes to infection and to the onset of multiorgan failure, increasing morbidity and mortality, the mean length of hospital stay, and health costs. Aim: A prospective cohort study of children admitted to the tertiary pediatric ICU between January 2009 and January 2014 was carried out. To assess the malnutrition type, and impact of nutritional status on outcomes like mortality rate, disease, complication in critically ill children.To the study were enrolled 138 children admitted to the pediatric intensive care units of the NationalCenter for Maternal and Childrens Hospital. The study protocol was approved by the Ethics Committee of the MNUMS, and written informed consent was obtained from all study participants. Nutritional status was determined using Waterlow criteria.Total participants were 49.3% (n=68) of male, 50.7% (n=70) female. 138 children with a mean age 4.4 months ±3.6/ Std.Er/, min = 1 month, max = 12 months, mode = 1 month. n=70(50.7%) acute malnutrition, n=58(42%) chronic malnutrition by Waterlow criteria. In malnutrition group was assessed patient with ricket n=36 (26.1%), patient with anemia n=56(58.9%)While malnutrition is a major problem in pediatric intensive care units. Acute malnutrition moreoccurred in the pediatric intensive care.Malnutrition more occurring of intrauterine infection, genetic disorder, hematology disease’s patients.
2.Some results obtained from in vitro quality evaluation of leading brands of ciprofloxacin tablets marketed in Mongolia
Azjargal G ; Anudari T ; Tsetsegmaa S ; Gereltuya D
Mongolian Pharmacy and Pharmacology 2018;13(2):21-26
Introduction:
Ciprofloxacin is a broad-spectrum antibiotic that acts against a number of
bacterial infections. The study was carried out to examine the in vitro quality control tests for five
leading brands of ciprofloxacin hydrochloride 500 mg tablet formulation, registered in Mongolia. The
quality control parameters of five different brands of ciprofloxacin hydrochloride 500 mg tablets were
determined weight variation, friability, hardness, and disintegration, dissolution and assay tests. In
addition, 0 and first order kinetic models were applied for each sample.
Method:
All the tablets were evaluated for conformity with British Pharmacopoeia (BP) and
Mongolian Pharmacopoeia-National Formulary (MP-NF) standards.
Results:
Among five brands of tablets Brand C had lower mean weight variation of 0.8% and
Brand A had highest mean weight variation of 3.42%. For friability test Brand B had the lowest mean
friability (0.57) and Brand A had highest mean friability (1.51). The percentages of the drug content
of five brands of ciprofloxacin tablet were obtained in the following sequence: Brand E (98.4 %) <
Brand C (100.3%) < Brand D (115.1%) < Brand A (138.5%) < Brand B (183.8%). E and C brands met
the BP and MP-NF specifications for assay
Conclusion
The present study revealed that Brand A, B and D the leading brands of this
tablet not met the quality control parameters as per pharmacopoeia specifications expect dissolution
test for some brands (Brand A, Brand B).
3.First case of endovascular surgery with rotablation
Lhagvasuren Z ; Baasanjav N ; Batmyagmar Kh ; Narantuya D ; Erdembileg D ; Batzaya Ts ; Gereltuya Ch
Mongolian Medical Sciences 2020;191(1):96-99
Introduction
In 1987 Jerome Ritchie, David Auth and colleagues first introduced rotational atherectomy (rotablation)
as a technique for the endovascular treatment of obstructive atherosclerotic disease. Rotational
atherectomy covers 3-5% of all procedures in big PCI centers, while <1% in smaller centers. By
study of Warth DC et al. in 1994, at early period when it was first introduced, procedure complication
of rotablation was about 40%, those with coronary dissection 29%, coronary artery occlusion 11.2%,
side branch occlusion 1.8%, distal occlusion 0.9%, no relow phenomenon 6.1%, severe vasospasm
13.8% and vascular perforation 1-2%.
By advanced techniques and technologies that kind of complications reduced significantly, it occurs
as same as other PCI procedures.
In our country PCI procedure was first introduced in Third State Central Hospital in 2000, since then
20 years has passed. During this period coronary intravascular diagnosis and treatment developed
progressively performing 14751 PTCA procedures, of those 8355(56,6%) PCI cases. By statistics
of 2017, myocardial infarction occurred 1145.6 in 10000 population, showing sharp increase, and
cardiovascular mortality became number one cause and has tendency to increase further.
To inform first outcome of rotational atherectomy of atherosclerosis that is severely calcified and
unavailable to introduce balloon catheter or stent. To conduct atherectomy treatment methods,
accustoming professionals, order and get ready the treatment materials for necessity.
We successfully performed rotablation in severely calcified mLAD of 56 years of male patient by
staged PCI, whose infarct related artery Lcx was revascularized 3 months previously. As a result the
patient was fully revascularized, the balloon catheter passed through the narrowing and stent was
implanted successfully.