Objective Investigate the effect of recombinant human growth hormone on large area burn with severely inhalation injury. Methods Forty cases of large area burn with severely inhalation injury were divided randomly into two groups, 20 in control group and 20 in rhGH group. The indexes of nutritional status (including MAMC,Hb,total protein,albumin and so far),healing time of burn wound,and the time of mechanical ventilation were recorded and compared between two groups. Results The nutritional status showed no difference between two groups before treatment,and was significantly better in rhGH group after treatment.The healing time of autologous skin pulp grafting and donor site,the time of mechanical ventilation and the length of hospital stay were significantly shorter in rhGH group patients than control group.Conclusion rhGH can enhance the wound healing rate,improve the nutritional status of patients with mechanical ventilation,shorten the time of mechanical ventilation,and decrease the complications of burn.