1.Significance of early treatment for prevention of secondary infection of severe acute pancreatitis
Chinese Journal of Hepatobiliary Surgery 2010;16(3):235-237
Secondary pancreatic infection in severe a-cute pancreatitis (SAP) was associated with mortality and the length of stay in hospital.Intensive Care Unit (ICU) identificate shock on account of the oxygen metaboilic level in earlier period of SAP and perform adequate fluid resuscita-tion.it advocate to perform organ function support and/or substitution therapy in time and think highly of coordination and combination each other among various kinds therapeutic measure.These therapeutic concept and measure will con-duce to decrease the incidence rate of MODS and secondary pancreatic infection accordingly in SAP.
2.Protective effects of angiotensin Ⅱ receptors antagonist on the LPS-induced lung acute injury
Chinese Journal of Emergency Medicine 2006;0(09):-
Objective To investigate the effects of angiotensinⅡ(AngⅡ) receptors antagonist on the LPS-induced acute lung injury (ALl).Method Wistar rats were randomly divided into three groups:control group;in LPS group,mrs were treated with LPS (10 mg/kg) at 3,6,12,and 24 hours;in LPS+ AngⅡreceptors antagonist group,pre-expasure to AngⅡreceptors antagonist [Sar~1,Ile~8] AngⅡfor 30 minutes before treated with LPS (10 mg/kg) for 6 hours.All the rats were killed,and the lung tissue was collected.Results Compared with control group pulmonary wet/dry weight ratio was significantly higher in the other two groups (P
3.An assessment of labial bone mass after immediate implant or delayed implant placement in esthetic zone
Wei FENG ; Shufeng WANG ; Jinyou GENG ; Yuanyuan SUN ; Haixia GENG
Chinese Journal of Medical Aesthetics and Cosmetology 2014;20(4):283-286
Objective To evaluate the alteration of labial bone mass one year after immediate implant or delayed implant placement in esthetic zone.Methods From June 2009 to June 2012,22 patients with 11 immediate implant and 11 delayed implant in the maxillary anterior region were followed up.CBCT images were obtained immediately after surgery and one year after implant placement,the horizontal and vertical alterations of the labial bone were evaluated by image analysis software.Results The 1-year vertical reduction of labial bone after immediate implant placement was statistically significant (P<0.05),and no significant difference in delayed implant (P>0.05).The 1-year horizontal reduction of labial bone was statistically significant at coronal and middle of implant,without significant difference at apical of implant.Conclusions Immediate implant can not stop the physical absorption of labial alveolar ridge,and the study can provide reference to achieve esthetics in the anterior region.
4.A short-term assessment of angulated abutments for the implant denture restorations in posterior teeth
Wei FENG ; Jinyou GENG ; Yuanyuan SUN ; Haixia GENG
Chinese Journal of Tissue Engineering Research 2014;(7):1021-1026
BACKGROUND:As the rapid development of oral implantation and restoration techniques, as wel as the increasing enlargement of indications, angulated abutments have been widely used. Posterior teeth region, as the weight-loading region of occlusion, can bear great force from the implants, the assessment of angulated abutments in posterior teeth region has clinical value.
OBJECTIVE:To evaluate the short-term clinical efficacy of angulated abutments on the implant denture in posterior teeth region.
METHODS:From January 2008 to January 2013, 114 patients with 175 ITI implants in the posterior teeth region were included in this study and they al underwent single-crown restoration. The involved patients were divided into angulated abutment group and straight abutment group. Periodontal probing depth, modified plaque index, modified sulcus bleeding index and peri-implant crestal bone loss in two groups were recorded at 6 months and 2 years after restoration. Cumulative survival rate of the implant denture was calculated by life-table analysis.
RESULTS AND CONCLUSION:There was no significant difference in periodontal probing depth, modified plaque index, and modified sulcus bleeding index between two groups (P>0.05). The annual crestal bone loss showed no significant difference between two groups (P>0.05). Moreover, the 5-year cumulative survival rate with 15° and 20° abutments was 95.6%, and that with straight abutment was 96.4%. The angle of abutments has no correlation with peri-implant soft tissue and peri-implant crestal bone loss, implant restorations with 15° and 20° angulated abutments may be successful y used in the posterior region, whereas the long-term effects need further research.
5.Protective effect of the ginger oil on experimental acute hepatic injury
Tao GENG ; Meilin XIE ; Xiaofei SUN
Chinese Traditional Patent Medicine 1992;0(08):-
AIM:To investigate the protective effect of ginger oil on liver.METHODS:Mouse model of acute hepatic injury induced by carbon tetrachloride and acetaminophen were used to observe the protective effect of ginger oil on liver.RESULTS:Ginger oil could obviously decrease ALT and AST levels of mouse model of acute hepatic injury induced by carbon tetrachloride and acetaminophen,significantly decrease MDA level of rat liver tissue and mouse serum(P
7.Clinical study of recombinant human endostatin with GP regimen in the treatment of advanced non-small-cell lung cancer
Ming GU ; Limin GENG ; Hongyi SUN
Cancer Research and Clinic 2011;23(10):690-692
Objective To evaluate the efficacy and security of combined recombinant human endostatin with GP chemotherapy for the treatment of advanced non-small-cell lung cancer (NSCLC).Methods Non- randomized concurrent control was used.32 patients were treated by recombinant human endostatin combined with chemotherapy as test group,40 patients of control group only received chemotherapy.The response rate (RR),the clinical benefit rate (CBR) and the time to progression (TTP) were observed.Results The total RR in two groups were 40.6 % and 20.0 % (x2 =3.66,P =0.07).The total CBR were 68.8 % and 42.5 % (x2 =4.93,P =0.034).The total time to progression were 5.2 months and 3.9 months (P =0.042).Incidence of adverse reactions of experimental group and control group was no significant difference.Conclusion Combined recombinant human endostatin and chemotherapy can improve the curative effect (RR,CBR and TTP) of advanced NSCLC.
8.Analysis of association between clinical manifestation and polymorphism of matrixmetalloproteinase-9 C-1562T gene in patients with IgA nephropathy
Mindan SUN ; Ping LUO ; Xinghua GENG
Journal of Jilin University(Medicine Edition) 2006;0(04):-
0.05).Conclusion On clinical,MMP-9 C-1562T genotype of IgA nephropathy patients may impact on the degree of urinary protein,but not other clinical manifestations,and prognosis of IgA nephropathy.
9.Clinical analysis of 30 patients with severe facial and neck cut wound treatment.
Jian ZHOU ; Geng-lin SUN ; Wei WU
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2012;47(2):152-153
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Child
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Child, Preschool
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Facial Injuries
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therapy
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Female
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Humans
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Male
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Middle Aged
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Neck Injuries
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therapy
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Retrospective Studies
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Wounds, Penetrating
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therapy
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Young Adult
10.Mechanism of inhibitory effect of interferon and its related signal pathway on the invasion of glioma
Yanqi SUN ; Yeqing REN ; Geng GUO
Journal of International Oncology 2021;48(3):172-175
Glioma is a tumor with a high incidence of intracranial tumor. Because of its high degree of malignancy, strong invasiveness and high mortality, the current conventional treatment cannot achieve the desired therapeutic effect, which greatly affects the quality of life of patients. As a protein with the functions of anti-proliferation, anti-angiogenesis and anti-invasion, interferon is widely used in the treatment of all kinds of tumors in clinic. Many studies have shown that interferon plays an important role in the occurrence and development of gliomas. To explore the mechanism of interferon and its related signal pathway in the process of glioma invasion, and to study the new treatment of glioma is very necessary in clinical treatment.