OBJECTIVE To discuss cause and nursing of hospital infection in infectious disease ward.METHODS Hospital infection in infectious disease ward of a general hospital was analyzed retrospectively.RESULTS The hospital infection rate was 6.18%;the main site of infection was respiratory tract(48.84%);November is the highest month of infection rate.The infection rate was seen higher among liver disease patients.CONCLUSIONS The hard ware must be enhanced to reform and the sickroom arrangement be regularized.It is important for hospitals to strengthen infection control.The main treatment to control hospital infection is applying aseptic operation strictly.