Objective To explore the effect of propofol on tumor necrosis factor-alpha(TNF-?),interleukin-6(IL-6),interleukin-8(IL-8)in rats following renal ischemia/reperfusion and the protection of propofol on renal ischemia-reperfusion injury.Methods Seventy-two adult SD rats were randomly divided into three groups:sham operation group,ischemia/reperfusion group(I/R group)and propofol group(n=24 in each group).All the indexes of the last two groups were detected on 1,4 and 24 h after reperfusion.Five minutes before ischemia in propofol group,propofol was infused by vein and isometric physiologic saline to the other two groups.The concentration of IL-6,IL-8,TNF-? in serum and renal tissue,BUN and SCr in serum were measured.Hematoxylin and eosin staining for the renal tissue was processed.Results The concentration of IL-6,IL-8,TNF-? in serum and TNF-? in renal tissue in propofol group within 1 h after reperfusion was significantly lower than I/R group(P

Objective To improve and evaluate the diagnosis and treatment of retroperitoeal fibrosis. Methods From February 1975 to December 2001, 36 cases (male: 20, female: 16) of retroperitoneal fibrosis were treated, 12 of whom were primary fibrosis and 10 were secondary to malignant tumors and the others were secondary to radiotherapy of malignant tumors. Surgical intervention was undertaken in 28 patients with preoperative and postoperative administration of corticosteroids. Results The patients were followed up for 6 to 42 months with improved or normal renal function. Most of them had very good results. Death secondary to malignancy was found in 4 cases. Conclusion To relieve the obstruction due to hydronephrosis by surgical intervention is very effective in treatment of retroperitoneal fibrosis.