OBJECTIVE: To evaluate the value as well as correlation between blood drug level and blood routine results in patients using cyclospone A (CsA) following renal transplantation via analyzing varies of immunosuppressive agents used in renal transplantation. METHODS: Retrieval-related contents were collected by computer from Chinese Journal Full-Text Database with of "renal transplantation, CsA, and therapeutic drug monitoring". Simultaneously, data of patients who received CsA treatment after renal transplantation in the Department of Laboratory, Liaoning Provincial Electrical Hospital were selected. All the literature was retried and analyzed. RESULTS: A total of 717 patients were included in the final analysis. It demonstrated that 6 sorts of immunosuppressive agents, such as mizoribine, sirolimus, zenapax, mycophenolate, and basiliximab play an important role in immune suppression after organ transplantation. However, there still exist problems need to be further explored. CsA was more suitable for clinical application with lower price and good curative effect, which worked better combined with other immunosuppressive agents. CONCLUSION: A best curative effect of CsA can be achieved by timely adjusting therapeutic regimen under the patient's condition. Meantime, a high efficiency and low toxicity drug with specific tolerance is the ultimate goal of immunosuppressive agents.

Acute myeloid leukemia (AML) is a highly heterogenous disease with multiple signaling pathways contributing to its pathogenesis.A key driver of AML is the mutation of FMS-like tyrosine kinase receptor-3 (FLT3) gene.Mutations in FLT3,primarily the FLT3-internal tandem duplication (FLT3-ITD),are associated with decreased progression-free and overall survival.Due to the importance of FLT3-ITD and its pathway in the prognosis of patients with AML,it has stimulated efforts to develop therapeutic inhibitors of FLT3.Although the FLT3 inhibitors show a certain degree of antileukemia activity,their clinical effect has some limitations as a single drug.Now,Quizartinib (AC220) is the potent second generation FLT3 selective inhibitors.Based on the resistance mechanism for FLT3 inhibitom,more and more scholars has been studying the inhibition of FLT3-ITD+ cell lines and primary leukemia cells by AC220 alone and in combination with cytotoxic chemotherapies/protein kinase inhibitors as well.However,the clinical effects of a variety of combination plan remain to be further investigated.

In order to adapt to the changes of medicine mode and market needs, the Nursing Department of Fujian TCM gave an elective course of nursing etiquette, and made teaching designs for the course, including the designs of teachers training, teaching objects, teaching contents and teaching methods. At the end of the course, the authors conducted questionaire, interview and examination among the students, and analyzed the data by statistical methods, and believed that the result was good. Besides, the article discussed the meaning of setting the Nursing etiquette course, and gave some suggestions on the course building.

Child ; Dental Occlusion ; Humans ; Tooth Eruption

Taking the basic theory of Chinese medicine as the instruction, through the bidirectional features of clinical manifestations, the relative etiology and pathology, acupoints and treatments, the bifunctional law in acupuncture theory is discussed. And it is held that after the confirmation of bidirectional symptoms of some diseases or syndromes, acupoints which have special functions in the bifunctional theory of acupuncture with a narrow meaning can be taken as major acupoints. And at the same time, other proper acupoints and flexible treating methods can be selected under the instruction of the bifunctional law of the broad meaning, so as to get the best therapeutic effect.
Acupuncture Points ; Acupuncture Therapy ; Humans ; Medicine in Literature ; Meridians

On the basis of related literature, this paper analyzed that the traditional Chinese medicine combinated with chemotherapy can improve the clinical effect of middle-late phrase gastric cancer patients and improve their quality of life, reduce adverse reaction of chemotherapy, prolong survival period.

The Chinese medicine could alleviate clinical symptoms, improve the quality of life in the treatment of lung cancer with malignant pleural effusion. TCM showed its certain characteristics and advantages. This paper summarized the literatures about the treatment of lung cancer with malignant pleural effusion with Chinese medicine in recent years in the light of oral Chinese herbal medicine, external use of Chinese medicine, pleural perfusion with traditional Chinese medicine.

The university students must promote themselves to become persons with sound personality in order to adapt to the society request for talents.But the university students experience emotion burnout and the deviation of development in mental and behavior during the period full of variety and surging.So the education of sound personality should be placed in the higher education to raise the university student's comprehensive character.

First of all,all tutors as well as postgraduates should have concept of innovation.Secondly,favorable environment should be built up for innovative thoughts.Finally,tutors should try their best to cultivate students'innovative thoughts and direct their creationary practice.

Embryonic stem(ES) cells are derived from totipotent cells of the early mammalian embryo and are capable of unlimited, undifferentiated proliferation in vitro. The establishment of mouse ES cell lines demonstrated the unmatchable convenience for the study of mouse embryonic development and the particular gene regulation and function. It has been long expected to construct such cell line for human. Here we summarized the development in the construction of human ES cell line, its potential utilization in various fields and the possible ethical dilemmas it brought with were also discussed.