OBJECTIVE:To observe clinical efficacy and safety of flupirtine maleate for pain caused by acute lumbar sprain. METHODS:60 patients with acute lumbar sprain were selected and divided into trial group and control group according to even and odd-numbered admission order. Trial group received flupirtine maleate capsule,1 piece/time,3 times/d;control group was giv-en codeine sustained-release tablet,2 tablets/time,2 times/d. The VAS score,clinical efficacy and ADR were compared between 2 groups. RESULTS:The VAS score of treatment group after treatment was significantly lower than that of control group,with statis-tical significance(t=2.375,P=0.013). The clinical efficacy of trial group was significantly higher than that of control group,with statistical significance (u=9.431,P=0.024). The ADR of trial group was mild,and there was no significant difference between two groups(χ2=0.131,P=0.717). CONCLUSIONS:Flupirtine maleate has a good clinical efficacy and safety in the treatment of pain caused by acute lumbar sprain.

The catabolic response to severe injury , burn, inflammatory ,acute pancreatitis and operation is characterized by whole-body protein loss, mainly reflecting increased breakdown of muscle proteins. Glucocorticoids and various proinflammatory cytokines are important regulators of muscle proteolysis in stressed patients. In recent years, three types of treatments have been used to reduce or prevent the catabolic response to injury and sepsis: ①nutritional, ②hormonal, and ③pharmacologic. This article review the catabolic response and the corresponding interruption under the stress conditions.

Lung transplantation is now considered one of the effective management of end stage pulmonary diseases. This review presents the recent progress of primary graft failure in lung preservation, such as low temperature, ventilation, etc. The purpose is to provide some valid methods in clinical practice.

Stem cell therapy for myocardial repair after myocardial infarction is a new and promising treatment modality.But the mechanism is still not very clear.Currently,stem cells are used in clinical study to evaluate its beneficial effect on repairing infarcted/hibernating myocardium after myocardial infarction and heart failure.But there is no final conclusion on the safety of stem cell transplantation.

The current pharmacotherapy is inadequate in preventing the progression of ventricular remodeling and congestive heart failure. Cellular cardiomyoplasty, through cell transplantation or regeneration of cardiomyocytes is a potential therapeutic approach to prevent left ventricular remodeling and the development of congestive heart failure after myocardial infarction. Recent research has focused on stem cells, which are undifferentiated pluripotent cells and can differentiate into a wide variety of cells including cardiac myocytes and endothelial cells. The majority data on stem cell transplantation were preclinical animal studies, all showing that stem cell therapy may replace lost heart muscle (myogenesis) and enhance cardiovascular revascularization (angiogenesis and vasculogenesis). These findings have been rapidly applied to human trials, but there were many questions remain to be solved. Although the results are interesting and safe, early phase Ⅰ clinical studies are small in scale and very preliminary. Data from large, randomized controlled trials are needed to confirm the short- and long-term effects of cellular cardiomyoplasty.

Lots of problems has exposed in medical system,especially in unreasonable utilization of health resources.This article,from the viewpoint of utilization of health resource,analyzes current problems and countermeasures of the reasonable utilization of health resources.

Objective To analyze and evaluate the efficacy of intramedullary interlocking nail in the treatment of long bone fractures.Methods From July 1997 to October 1999,100 cases of long bone fractures were treated intramedullary interlocking nail,including 25 fractures of tibia and fibula at middle site tibia,35 at middle-lower,31 middle femoral,9 middle-lower of femoral.Results The period from 3 to 19 months with an average of 13 months for followed-up.The average fracture healing time was 14 weeks.According to Johnenand-Wruh evaluation method,98 of 100 patients(98%) were excellent osteosythesis,one case was good and only one case was bad.Conclusions The treatment of long bone fractures with intramedullary interlocking nail is a good way.It has high healing rate,and pathologic rigidity of joint movement is fewer.But the method has some limits for operative indication and its special complications also to be explored further.

OBJECTIVE:To identify Salvia miltiorrhiza,Rehmannia,Chuangxion rhizome,rhubarb and to determine the content of tanshinone Ⅱ A,as an efficacious composition,in Shendi Tangmaining capsules.METHODS:TLC and SPE-UV were used.The SPE-UV method was performed with silica gel column(1.1cm).The mobile phase consisted of dichloromethane-me_thanol(8∶2).The detected wavelength was 280nm.RESULTS:In the SPE-UV method,the standard curve for tanshinone Ⅱ A was linear in the range of 1.6～8?g/ml(r=0.9 999).The average recovery was 96.13% with RSD=0.80%.CONCLUSION:The method is simple,rapid and reliable for quality control of the capsules.

Objective To evaluate the influence of angiotensin converting enzyme (ACE) gene polymorphism on the effect of aerobic endurance training of soldiers.Methods Two hundred and forty-eight army recruits (males,Hans) from an infantry regiment without previous history of military training were involved in the present study,and they were divided into experimental group and control group (124 each).Intensified endurance training designed with the theory of "cyclic training" was applied in experimental group,and routine training method was applied in control group including mainly 5000 meters running for 3 times in one week (no more than 1 time per day).The 5000m running performance and maximal oxygen consumption (VO_2max) were determined before and after eight-week training as endurance capacity indices.The ACE gene polymorphism was determined and the recruits in both groups were divided into 3 sub-groups according to the ACE genotypes as II,ID and DD.The influence of ACE genotype and training method on endurance capacity was analyzed.Results The 5000m running performance and VO_2max of experimental group after eight-weeks-training were significantly higher than those before training and those of control group (P0.05).In control group,the 5000m running performance and VO_2max of DD sub-group were significantly lower than those of II sub-group and ID sub-group (P0.05).Conclusions Intensified endurance training designed with the theory of "cyclic training" may effectively improve the endurance capacity in 8 weeks.ACE genotype could not be used as an accurate indicator to evaluate the endurance capacity and improvement of efficiency of soldiers.

Objective To explore an appropriate training method to quickly improve the soldiers' aerobic endurance capacity and decrease the incidence of military training injuries for combat troops. Methods Two hundred and forty-eight recruits (males,Hanzu) from infantry without previous history of military training were involved in the present study,and they were divided averagely into experimental group and control group (124 each). Intensified endurance training designed with the theory of "cyclic training" was applied in experimental group,and routine training method was applied in control group including mainly 5000 meters running (no more than once a day,3 times a week). The resting pulse,vital capacity,maximal oxygen consumption (VO2max) and the performance of 5000m running were determined before and after eight-week-training as endurance capacity indices. Physical examination was performed to count the cases of military training injuries including calf swelling and tenderness,knee swelling and pain,and low back pain,and then the incidence of military training injuries was calculated. Results In the experimental group,the resting pulse decreased by 8.0%,while the vital capacity,VO2max and 5000m running performance elevated by 8.1%,20.0% and 14.7% respectively after training,which were significantly different in comparison with that before training and of control group (P