1.Chemical constituents of Dai ethno-medicine Rhinacanthus nasutus
Jieying YE ; Qingzhi ZHANG ; Gaoxiong RAO
Chinese Traditional and Herbal Drugs 1994;0(06):-
Objective To study the chemical constituents of the Dai ethno-medicine Rhinacanthus nasutus.Methods The chemical constituents had been spearated with chromatography and their structures were determined by spectral analyses.Results Nine compounds and two mixture were isolated and identified as C26—C32 alkyl mixture(Ⅰ),?-monopalmitin(Ⅱ),palmitic acid(Ⅲ),stearic acid(Ⅳ),lignoceric acid(Ⅴ),?-sitosterol(Ⅵ),lupeol(Ⅶ),p-hydroxy benzoic acid(Ⅷ),daucosterol(Ⅸ),?-ethyl-D-idosopyranoside(Ⅹ),and mixture of KNO3 and NaNO3(Ⅺ).Conclusion Compound Ⅹ is a new artificial compound during isolation and compounds Ⅰ—Ⅴ,Ⅷ—Ⅺ are isolated from R.nasutus for the first time.
2.Comparison of active components in two processed products of Polygonum multiflorum
Fengjiang XIE ; Ronghua ZHAO ; Shenglan ZHAO ; Gaoxiong RAO
Chinese Traditional and Herbal Drugs 1994;0(07):-
Objective To provide basis for choosing a proper processed method of Polygonum multiflorum.Methods To compare and analyze main active component changes in the processed products of P.multiflorum by being steamed without any adjuvants and with soya-bean milk of different concentrations.Results There was no marked difference for variously processed products in the main active components,anthraquinone and stilbene glucoside in P.multiflorum.Conclusion It is feasible to replace the steamed with soya-bean milk by the steamed without any adjuvants.
3.Flavonoids in leaves of Alstonia scholaris.
Tingting HUI ; Yun SUN ; Liping ZHU ; Wen GUO ; Gaoxiong RAO
China Journal of Chinese Materia Medica 2009;34(9):1111-1113
OBJECTIVETo investigate the flavonoids in leaves of Alstonia scholaris, an ethno-remedy of Dai People in Yunnan.
METHODThe chemical constituents were isolated and purified by column chromatography. Their structures were elucidated on the basis of spectroscopic evidences and physicochemical properties.
RESULTEight flavonoids were isolated and identified as kaempferol (1), quercetin (2), isorhamnetin (3), kaempferol-3-0-beta-D-galactopyranoside (4), quercetin-3-0-beta-D-galactopyranoside (5), isorhamnetin-3-0-beta-D-galactopyranoside (6), kaempferol-3-0-beta-D-xylopyranosyl-( 2-1)-0-beta-D-galactopyranoside (7) ,quercetin-3-0-beta-D-xylopyranosyl-( 2-1)-0-beta-D-galactopyranoside (8).
CONCLUSIONFlavonoids 1-7 were isolated from A. scholaris for the first time.
Alstonia ; chemistry ; Flavonoids ; analysis ; isolation & purification ; Plant Leaves ; chemistry
4.Synthesis and anti-tumor activity in vitro of N-hetercycle substituted benzofuran derivatives
Zewei MAO ; Chunping WAN ; Yuan JIANG ; Wenlian GUO ; Gaoxiong RAO
Journal of China Pharmaceutical University 2015;46(1):58-61
To discover the novel compounds with biological activity, N-hetercycle substituted derivatives were synthesized based on the structure of benzofuran. A series of novel N-hetercycle substituted benzofuran derivatives(2a-2j)were synthesized by the reaction of 2-(4′-florobenzoyl)benzofuran with N-heterocyclic compounds. And the structures were characterized by 1H NMR, 13C NMR and HRMS. Their anti-tumor activities were studied in vitro against a panel of human tumor cell lines(HeLa, A549 and H1975)by the MTT assay. The results indicate that compounds 2a, 2f and 2j are the most potent within this series of compounds against human tumor cell lines, showing that they are promising lead compounds for further structural modifications and biological evaluation.