1.Effect of Lidan decoction combined with magnesium isoglycyrrhizinate in the treatment of liver injury after radiofrequency ablation for liver cancer
Chinese Journal of Primary Medicine and Pharmacy 2019;26(1):37-39
Objective To observe the effect of Lidan decoction combined with magnesium isoglycyrrhizinate in the treatment of liver injury after radiofrequency ablation(RFA) for liver cancer. Methods From February 2015 to February 2016,60 liver cancer patients with liver injury after RFA in the People's Hospital of Haiyang were selected in this study. The patients were randomly divided into the observation group and control group,with 30 cases in each group. The observation group was given Lidan decoction combined with magnesium isoglycyrrhizinate,and the control group was given conventional therapy. Results After treatment,the total effective rate of the observation group was 90. 00% (27/30),which was higher than 66. 67% (20/30) of the control group (χ2=4. 811,P<0. 05). The levels of albumin (ALB),direct bilirubin (DBIL),AST,ALT in the observation group were (39.02 ±0.91)g/L,(6.31 ± 0.71)μmol/L,(59.12±5.81)U/L,(54.18±8.31)U/L,respectively,the differences were statistically significant between the two groups (t=7. 199,6. 211,6. 440,7. 928,all P<0. 05). Conclusion Lidan decoction combined with magnesium isoglycyrrhizinate is effective in treating liver cancer patients with liver injury after RFA.
2.Clinical observation of Bazhen decoction Huaji pill combined with chemoembolization in the treatment of primary liver cancer
Chinese Journal of Primary Medicine and Pharmacy 2019;26(2):157-160
Objective To observe the clinical effect of Bazhen decoction Huaji pill combined with transcatheter arterial chemoembolization ( TACE) in the treatment of primary liver cancer. Methods From December 2016 to October 2017,76 patients with primary liver cancer admitted to the People's Hospital of Haiyang were selected. According to the different clinical treatment methods,the patients were divided into two groups,with 38 cases in each group. The control group received hepatic arterial chemoembolization, and the observation group received Bazhen decoction Huaji pill combined with TACE. Results The total remission rate of the patients in the observation group was 63. 16% (24/38),which was significantly higher than 23. 68%(9/38) in the control group (χ2 =12. 050,P<0. 05). The improvement rate and stability rate of KPS score in the observation group were 47. 37%(18/38),36. 84%(14/38),respectively,which were higher than those in the control group [26. 32%(10/38),31. 58%(12/38),χ2 =6. 397,P<0. 05]. The incidence rate of adverse reactions in the observation group was 21. 05%,which was lower than 44. 74% in the control group,the difference was significant(χ2 =4. 828,P<0. 05). Conclusion Bazhen decoction Huaji pill combined with TACE in the treatment of patients with primary liver cancer can effectively alleviate the patients'condition,improve the quality of life of patients,and has high safety. It is worthy of popularization and application.
3.Preventive effect of salmeterol xinafoate and fluticasone propionate aerosol on radiation pneumonia in local advanced non-small cell lung cancer: a clinical study
Yingqiang JIANG ; Hui ZHONG ; Ming LI ; Gaoping SONG
Cancer Research and Clinic 2016;28(8):534-537,557
Objective To observe the preventive effect of salmeterol xinafoate and fluticasone propionate aerosol on radiation pneumonia in patients with local advanced non-small cell lung cancer (NSCLC) after radiotherapy.Methods Sixty-four patients with local advanced NSCLC were randomly divided into the study group and the control group.Both groups were treated with intensity modulated radiation therapy treatment and routine interventions.Salmeterol xinafoate and fluticasone propionate aerosol were given to the study group from the first day of radiation therapy at both the morning and evening time.Clinical symptoms,chest CT,Karnofsky score and tumor necrosis factor-α (TNF-α) levels in the two groups were analyzed at the time before radiotherapy and three months after radiotherapy.Results The radiation pneumonia incidence of the study group was lower than that of the control group [21.9 %(7/32) vs 46.9 %(15/32)].The plasma TNF-α content after radiotherapy of the study group was lower than that of the control group [(9.18±3.45) ng/ml vs (13.38 ± 2.75) ng/ml].Moreover,the Karnofsky score of the study group was higher than that of the control group [(81.67 ± 7.18) scores vs (75.00+ 6.74) scores].The differences between the two groups were statistically significant (all P< 0.05).Conclusion Salmeterol xinafoate and fluticasone propionate aerosol can reduce the radiation incidence of the patients with local advanced NSCLC,improve patients' quality of life after radiotherapy and prevent the radiation pneumonia.
4.Detection of Multiple Gene Mutations in Stool for Secondary Screening for Colorectal Cancer
Gaoping QIN ; Xiaoqiang WANG ; Likun YAN ; Yong SONG
Chinese Journal of Bases and Clinics in General Surgery 2003;0(06):-
Objective To evaluate the possibility of detection mutations of multiple genes in stool for secondary screening for colorectal cancer.Methods Tumor specimens and stool samples from 40 patients with colorectal cancer and 40 normal persons were examined for mutations of p53,K-ras and APC gene by polymerase chain reaction single strand conformation polymorphism(PCR-SSCP) and silver nitrate staining.Results ①The mutation rate of p53,K-ras and APC gene in the tissues and stools of colorectal cancer respectively were 57.50%,50.00%,60.00% and 42.86%,40.00%,51.43%,and no mutations were found in normal mucosa and stool.②The mutation ratioes between multiple gene and single gene had significant difference(P
5.Wernicke encephalopathy after long period of TPN:A clinical analysis
Gaoping QIN ; Xiaoqiang WANG ; Jian QIU ; Yong SONG
Parenteral & Enteral Nutrition 2004;0(05):-
objective:To investigate the cause,pathogenesis,diagnosis and treatment of Wernicke encephalopathy(WE) after total parenteral nutrition(TPN). Methods:A retro spective study was conducted on 20 cases of clinical data about WE after long period of TPN. Results:WE usually occurred in the 2th~3th week of TPN support.18 cases of WE were treated with vitamin B_(1) in time,their symptoms disappeared and survived.2 patients died with misdiagnosis. Conclusion:Vitamin B_(1) is the key point to prevent and treat WE after long period of TPN.
6.Treatment of Mycobacterium abscessus infection caused by facial injection of unknown drugs
Feng HAN ; Gaoping QIN ; Yuan ZHU ; Song ZHANG ; Jianwu LI ; Yaowen SUN
Chinese Journal of Plastic Surgery 2023;39(10):1074-1081
Objective:To analyze the characteristics of local histological damage in patients with Mycobacterium abscessus infection caused by facial drug injection, and propose a treatment. Methods:The patients of Mycobacterium abscessus infection caused by facial injection of unknown drugs ( "osteolytic needles" ) admitted to Shaanxi Provincial People’s Hospital from September 2021 to June 2022 were analyzed retrospectively. Secretions were collected from the infected site for smear examination before surgery, and perform ultrasound, CT, MRI, and other related examinations. Surgical debridement was performed on the infected site under the assistance of endoscope and the guidance of B-ultrasound. During the operation, the infection was demonstrated to affect the facial superficial musculoaponeurotic system, even the deep muscle and bone tissue. The necrotic and degenerative tissue was completely removed and then the secretion was sent to bacterial culture and drug susceptible test, and the resected tissue was sent to pathological examination for HE staining. After debridement, the wound was not sutured. The vacuum sealing drainage (VSD) technique was used to treat the wound. The cavity was irrigated with 50 ml of normal saline+ 100 000 U of amikacin, and the wound was sutured after the wound was completely healthy and the secretion culture was negative. Drug treatment: first, according to the results of secretion smear examination (positive acid-fast bacteria), empirically apply cefoxitin or amikacin injection. After the infection was confirmed by bacterial culture, oral clarithromycin and minocycline were added, and bicyclol tablets were orally administered to protect liver function. Intravenous drip of cefoxitin or amikacin injection during hospitalization according to the results of drug susceptible test. After discharge, clarithromycin or minocycline and bicyclol tablets were used for 3-6 months, and the blood routine test and liver and kidney functions were examined every 2 weeks. Regular outpatient re-examination was carried out to observe whether there is a recurrence of infection and the recovery of facial appearance in the wound. Results:A total of 10 patients were included, including 1 male and 9 females, aged 19-28 years, with an average age of 25.3 years. The clinical manifestations were local redness and swelling in the zygomatic, buccal, periocular, or anterior temporal regions, low skin temperature, skin ulceration, purulent secretions, and palpable induration. CT and MRI results showed varying degrees of swelling and fluid accumulation in facial soft tissues, as well as locally structural and bone destruction. The results of secretion culture showed all patients were infected with Mycobacterium abscessus. Drug susceptible test results: sensitive to minocycline, cefoxitin, amikacin. HE staining showed exudative, proliferative and necrotic lesions, chronic suppurative inflammation and mixed granuloma lesions. Ten patients were hospitalized for 12-28 days, and their facial infections were well controlled. The wound healing was good. After 6 months of follow-up, there was no recurrence of facial infections and their appearance was generally normal. Conclusion:The local tissue damage caused by facial injection of unknown drug Mycobacterium abscessus infection is characterized as multiple layers, multiple sinuses, and bone destruction. Based on external debridement during treatment, drugs that are sensitive to Mycobacterium abscessus and have relatively small adverse reactions can be selected based on drug susceptible test results. Adherence to long-term and standardized treatment can achieve good results.
7.Treatment of Mycobacterium abscessus infection caused by facial injection of unknown drugs
Feng HAN ; Gaoping QIN ; Yuan ZHU ; Song ZHANG ; Jianwu LI ; Yaowen SUN
Chinese Journal of Plastic Surgery 2023;39(10):1074-1081
Objective:To analyze the characteristics of local histological damage in patients with Mycobacterium abscessus infection caused by facial drug injection, and propose a treatment. Methods:The patients of Mycobacterium abscessus infection caused by facial injection of unknown drugs ( "osteolytic needles" ) admitted to Shaanxi Provincial People’s Hospital from September 2021 to June 2022 were analyzed retrospectively. Secretions were collected from the infected site for smear examination before surgery, and perform ultrasound, CT, MRI, and other related examinations. Surgical debridement was performed on the infected site under the assistance of endoscope and the guidance of B-ultrasound. During the operation, the infection was demonstrated to affect the facial superficial musculoaponeurotic system, even the deep muscle and bone tissue. The necrotic and degenerative tissue was completely removed and then the secretion was sent to bacterial culture and drug susceptible test, and the resected tissue was sent to pathological examination for HE staining. After debridement, the wound was not sutured. The vacuum sealing drainage (VSD) technique was used to treat the wound. The cavity was irrigated with 50 ml of normal saline+ 100 000 U of amikacin, and the wound was sutured after the wound was completely healthy and the secretion culture was negative. Drug treatment: first, according to the results of secretion smear examination (positive acid-fast bacteria), empirically apply cefoxitin or amikacin injection. After the infection was confirmed by bacterial culture, oral clarithromycin and minocycline were added, and bicyclol tablets were orally administered to protect liver function. Intravenous drip of cefoxitin or amikacin injection during hospitalization according to the results of drug susceptible test. After discharge, clarithromycin or minocycline and bicyclol tablets were used for 3-6 months, and the blood routine test and liver and kidney functions were examined every 2 weeks. Regular outpatient re-examination was carried out to observe whether there is a recurrence of infection and the recovery of facial appearance in the wound. Results:A total of 10 patients were included, including 1 male and 9 females, aged 19-28 years, with an average age of 25.3 years. The clinical manifestations were local redness and swelling in the zygomatic, buccal, periocular, or anterior temporal regions, low skin temperature, skin ulceration, purulent secretions, and palpable induration. CT and MRI results showed varying degrees of swelling and fluid accumulation in facial soft tissues, as well as locally structural and bone destruction. The results of secretion culture showed all patients were infected with Mycobacterium abscessus. Drug susceptible test results: sensitive to minocycline, cefoxitin, amikacin. HE staining showed exudative, proliferative and necrotic lesions, chronic suppurative inflammation and mixed granuloma lesions. Ten patients were hospitalized for 12-28 days, and their facial infections were well controlled. The wound healing was good. After 6 months of follow-up, there was no recurrence of facial infections and their appearance was generally normal. Conclusion:The local tissue damage caused by facial injection of unknown drug Mycobacterium abscessus infection is characterized as multiple layers, multiple sinuses, and bone destruction. Based on external debridement during treatment, drugs that are sensitive to Mycobacterium abscessus and have relatively small adverse reactions can be selected based on drug susceptible test results. Adherence to long-term and standardized treatment can achieve good results.