Objective To investigate the clinical effects of Compound Biejia Ruangan Tablet (CBRT) combined with entecavir in patients with chronic hepatitis B with hepatic fibrosis.Methods Totally 92 cases of patients with hepatic fibrosis of chronic hepatitis B in Ankang people's hospital from January 2013 to May 2016 were divided into observation group (n =45) and control group (n =47),patients in observation group were treated with CBRT combined with entecavir,and patients in the control group were treated with entecavir.Treatment was for 48 weeks.The liver function,liver fibrosis,serum inflammatory factors,and adverse reactions were compared between two groups.Results After treatment,the ALT,AST,TBIL,and ALB/GLB levels of two group were significantly lower than those before treatment (P ＜ 0.05),but there was no significant difference between two groups after treatment.After treatment,the PCⅢ,IV-C,HA,LN,IL-6,IL-4,IL-10,and TNF-α levels of two group were significantly lower than those before treatment (P ＜ 0.05),and the PCⅢ,IV-C,HA,LN,IL-6,IL-4,IL-10,and TNF-α levels of observation group were significantly lower than those of control group (P ＜ 0.05);there was no statistically significant difference in the incidence of adverse reactions between two groups (P ＜ 0.05).Conclusion CBRT combined with entecavir is safe and effective to treat liver fibrosis of chronic hepatitis b,and it could significantly improve liver function,improve the degree of liver fibrosis,and reduce the level of serum inflammatory factors.

Objective:To discuss the efficacy of emergency endoscopic hemostasis combined with somatostatin in treatment of upper gastrointestinal hemorrhage.Methods:100 patients with upper gastrointestinal hemorrhage were selected and divided into two groups randomly.The control group (48 cases) was given conventional hemostatic measures.The observation group (52 cases) was given emergency endoscopic hemostasis combined with somatostatin.The efficacy of emergency endoscopic hemostasis combined with somatostatin in treatment of upper gastrointestinal hemorrhage was evaluated by efficacy,the curative success rate and the improvement situation of clinical symptoms.Results:The effective rate was 88.5 ％ in the observation group,and the effective rate was 70.8 ％ in the control group,and the effective rate of observation group was higher than that of the control group (P＜0.05).The success rate for different lesion size was higher in the observation group compared with control group (P＜0.05).According to the success rate,with the increased size of lesion,the hemostasis rate was decreased.The hospitalization,negative fecal occult and haematemesis disappeared time of observation group was shorter than that of the control group (P＜0.05).The postoperative bleeding rate of observation group was lower than that of the control group (P＜0.05).Conclusions:The emergency endoscopic hemostasis combined with somatostatin has a good therapeutic effect on upper gastrointestinal hemorrhage.It can improve the clinical symptoms and shorten the hospitalization time,but its effect is limited on large lesion of upper gastrointestinal hemorrhage.

Objective To investigate and analyze the situation of urban neglected children aged 3 to 6 in 9 districts of Chongqing .Methods Totally 1 316 children were randomly sampled under stratification from 18 streets of 9 district of Chongqing . Based on the Child Neglect Norms used by China ,prevalence of child neglect was identified and SPSS 13 .0 was employed for statis‐tical analysis .Scores ,frequency/degrees ,age ,sex and 5 types (physical ,emotional ,educational ,safety and medical) of child neglect on every group of the regions were calculated .Results The average prevalence of child neglect for the 3 to 6 year‐olds was 22 .95% ,and the total degree was 39 .56 ± 7 .19 .No significant differences were found in the prevalence and degree of child neglect between males and females and among age groups (P<0 .05) .The frequencies of child neglect for the five types were 5 .09% to 10 .64% ,with the higher frequencies of safety neglect (10 .64% ) and physical neglect (9 .50% ) .The degrees of child neglect for the five types were 36 .94 to 41 .24 ,with the higher degrees of educational neglect and physical neglect (41 .24 ± 10 .43 ,39 .81 ± 9 .32 respectively ) .No significant differences were found in the frequency of the types between males and females and among age groups . No significant differences were found in the degree of the types (with an exception on emotional neglect among age groups) between males and females and among age groups .The children aged 3 to 6 were mainly involved in single item of negligence ,with incidence rates as 13 .68% and proportions as 59 .60% .Conclusion The frequency and degree of child neglect among children aged 3 to 6 in the urban areas of 9 district of Chongqing were medium ,and similar between males and females and among age groups ,except the degree of emotional neglect .The children aged 3 to 6 had the higher frequencies of safety and physical neglect ,and the higher de‐grees of educational and physical neglect .The children aged 3 to 6 were mainly involved in single item of negligence .