Objective:To study the difference in dissolution behavior of clozapine tablets in four different media between the do-mestic preparations and original preparation to compare the internal quality of the tablets from various manufacturers and provide refer-ence for the drug control. Methods:Referring to the methods of in vitro dissolution test, the dissolution profiles of 46 batches of sam-ples from 18 pharmaceutical enterprises were determined in four kinds of dissolution media with different pH values, and the results were compared with that of the original drug by the method of f2 similarity factor. Results: Totally 46 dissolution profiles were drawn out. The profiles of two batches of samples from one pharmaceutical enterprise were similar to that of the original drug, which account-ing for 4%, and that of the other samples showed notable difference from that of the original drug. Conclusion:The preparation tech-nology of the tablets from domestic has great difference, which leads to significant difference in dissolution behavior. The screening and optimization of the production process in domestic pharmaceutical enterprises should be strengthened to improve the preparation technol-ogy of clozapine tablets.

Objective To investigate the relationship and clinical significance between the concentration of 25-hydroxy vitamin D3 [25-(OH)D3 ]in the serum and community-acquired pneumonia(CAP)in infants.Methods The study recruited 98 infants.There were 68 cases of mild pneumonia and 30 cases of severe pneumonia.The con-centration of 25-(OH)D3 in serum,IgA and alkaline phosphatase(AKP)were measured.33 infants who accepted physical examination in the outpatient department were selected as control group at the same time.Results The serum 25-(OH)D3 concentration of severe pneumonia was (21.09 ±7.32)ng/mL,mild pneumonia was (25.77 ± 8.06)ng/mL and the control group was (37.13 ±6.94)ng/mL.The differences among the three groups had statisti-cally significant differences(t =9.18,3.72,5.34,all P <0.05).The differences of serum IgA concentration among the three groups had statistically significant differences (t =5.42,3.96,8.92,all P <0.05).But serum AKP concen-tration among the three groups had no statistically significant differences(t =0.86,0.58,0.47,all P >0.05).The prevalence of Vitamin D deficiency was 40.0%,which was higher than mild pneumonia patients(20.6%)and the healthy children(9.1%)(χ2 =8.43,17.55,all P <0.05).Conclusion The serum 25-(OH)D3 concentration and IgA of CAP patients were lower than healthy children,especially in severe pneumonia cases.The prevalence of Vita-min D deficiency was significantly higher than healthy children.There were no relevance between the serum concentra-tion of 25-(OH)D3 ,IgA and AKP.25-(OH)D3 plays an important role in the development of CAP.The low level of serum 25-(OH)D3 concentration may be one of the risk factors and has correlation to the severity of pneumonia.

Objective To explore the effects of home care on pulmonary alveolar proteinosis patients. Methods The 24 cases of pulmonary alveolar proteinosis ( PAP) patients were divided into observation group and the control group on average. The patients of observation group received after discharge home care including health education, outpatient visits, telephone follow-up and on-site visits while the patients of control group had no this kind of interventions. Dyspnea index, six-minute walk test, pulmonary function tests and body mass index were compared between two groups after discharge. Results The dyspnea evaluation scores were (1. 31 ± 1. 07), (1. 29 ± 0. 62) and (1. 21 ± 0. 83) at 4, 8,12 weeks after discharged in the observation group and all were better than that of the control group (t=6. 438, 6. 897, 8. 572;P<0. 01). Six-minute walk test scores of observation group outbalanced scores in the control group at 4, 8,12 weeks after discharged (t=3. 214, 4. 316, 5. 673;P<0. 05). At 12 weeks after discharged,lung function of observation group were better than that of the control group(P<0. 05). The BMI differences between the two groups were not statistically significant(P>0. 05). Conclusions The implementation of home care can improve the PAP patients′ six-minute walk test distance and lung function, and reduce the patients with dyspnea index.