Background: Individuals requiring liver transplantation began receiving this procedure in Mongolia in 2011, following initial treatments abroad in 2004. As survival rates of post-liver transplant continue to improve, it is imperative to understand the factors influencing the quality of life for patients during these years and to explore modifiable determinants. The interplay between socioeconomic and environmental factors significantly impacts social and personal development, as evidenced by quality of life metrics. Research indicates that 6% of liver transplant recipients are classified as unable to work based on activity and international disability assessments, while 23% to 61% of recipients achieve full employment following liver transplantation treatment. However, there is a notable lack of studies examining the physical, psychological, and social well-being of patients post-liver transplant in Mongolia. This study aims to address this gap and provide insights into the overall health status of these individuals. Aim: Examining quality of life and employment status following liver transplantation treatment Materials and Methods: A descriptive study design and questionnaire method were used to collect data from 144 cases of individuals who underwent liver transplantation. The study was based on the SF-36 Health Survey, categorized into eight domains, with scores calculated according to predefined criteria. Results: Among the 144 cases included in the study, 81 (56.3%) were male and 63 (43.8%) were female. By age group, 120 (83.3%) were between 19 and 60 years old, representing the working-age population, while 24 (16.7%) were over 60 years old. Post-liver transplant employment status revealed significant differences, with 41 (28.5%) employed full-time, 19 (13.2%) parttime, and 84 (58.3%) unemployed or receiving disability benefits (p=0.024). Among these, 62 (43%) expressed a desire to work, 17 (12%) did not wish to work, and 65 (45%) were uncertain, showing no statistically significant differences (p=0.173). When calculating the quality of life assessment, the physical function index was 63.52±25.32 for working patients and 52.90±25.75 for non-working patients (p=0.018), and the psychological status index was 64.94±14.53 for working patients and 53.63±17.87 for non-working patients (p<0.001), and there was a statistically significant difference. Conclusion Health-related quality of life in people who are employed after liver transplantation is high, and overall physical function and overall psychological well-being improve year after year.