Objective To observe and explore the effect of aripiprazole(Ari)and olanzapine(Ola)on body weight and lipid metabolism in schizophrenia(SP)patients.Methods 96 patients with SP were randomly divided into two groups,48 cases in the observation group and the control group.The control group was treated with Ola,while the observation group was treated with Ari.Before and 6 weeks after treatment,the height,body weight,blood glucose (FBG),insulin(INS),low -density lipoprotein(LDL),triglycerides(TG),total cholesterol(TC)levels in the two groups were detected,insulin resistance index(IRI)and BMI were calculated.Results The differences of body weight,BMI,FBG,INS,IRI,LDL,TG,TC before treatment between the two groups were not statistically significant (t =0.161,0.564,0.277,0.078,0.092,0.124,0.421,0.245,all P >0.05).After 6 weeks treatment,FBG,INS, IRI in the observation group were (4.71 ±0.58)mmol/L,(21.85 ±12.36)μU /mL and (4.62 ±2.14),the differ-ences were not statistically significant compared with before treatment(t =0.800,0.571,0.276,all P >0.05).Those in the control group were (5.14 ±0.56)mmol/L,(28.54 ±11.25)μU /mL and (6.23 ±3.82),which were signifi-cantly higher than those before treatment(t =4.898,3.361,2.628,all P <0.05),and were also significantly higher than those in the observation group(t =3.695,2.773,2.547,all P <0.05 ).After 6 weeks treatment,the body weight,BMI,LDL,TG,TC in the observation group were not statistically significant compared with before treatment (t =0.262,0.638,0.124,0.421,0.245,all P >0.05 ),those in the control group were significantly higher than before treatment(t =2.601,3.834,5.773,5.838,4.375,all P <0.05),and were also significantly higher than those in the observation group(t =3.052,3.265,5.264,5.496,4.188,all P <0.05).Conclusion Ari treatment for SP has no significant effect on glucose and lipid metabolism and body weight in patients,and the effect of Ola treatment on patients'body weight and lipid metabolism is more significant.

Objective To observe the influence of mental rehabilitation combined with family intervention on self -efficacy and quality of life of patients with schizophrenia.Methods 92 cases of schizophrenia patients were choosed to be the research object.They were divided into control group (46 cases)and observation group (46 cases) according to random number table method.The control group was given mental rehabilitation while the observation group was given the mental rehabilitation combined with family intervention treatment.The clinical efficacy of the two groups of patients was observed after six months.The patient's self -efficacy was assessed by using self -efficacy scale (GSES),and the patient's quality of life was assessed by using the quality of life scale (QLQ).Results Six months after treatment,the score of PANSS in patients with positive symptoms[(14.19 ±4.16)points],negative symptoms [(16.29 ±4.92)points],mental symptoms[(35.56 ±6.75)points]and total score[(65.84 ±15.83)points]in the observation group were lower,which were better than those of the control group[(17.37 ±5.27)points,(21.11 ± 5.64)points,(42.37 ±7.92)points and (80.85 ±18.83)points],and the differences were statistically significant(t =3.212,4.368,4.438,4.544,all P <0.05).The total effective rate was 86.96% in the observation group,which was significantly higher than 67.39% in the control group,the difference was statistically significant(χ2 =4.998,P =0.025).The self -efficacy scores of the two groups were higher than before the treatment,which of the observation group[(3.51 ±0.62)points]was better than that of control group[(2.13 ±0.48)points],the difference had statistical significance(t =5.593,P =0.000).After treatment,the patient's quality of life score such as emotional function [(59.82 ±11.38)points],cognitive function[(69.43 ±12.32)points],role function[(69.77 ±12.31 )points], physical function[(75.38 ±14.01 )points],social function[(66.28 ±13.03)points]and so on were higher than before treatment[(56.88 ±10.36)points,(42.01 ±9.29)points,(47.02 ±9.17)points,(60.34 ±10.89)points, (53.92 ±10.76)points].Results of the observation group were better than those of the control group[(53.07 ± 10.13)points,(63.02 ±11.17)points,(62.03 ±11.17)points,(67.33 ±11.74)points,(60.87 ±12.62)points], the differences had statistical significance(t =3.005,2.664,3.158,2.987,2.023,all P <0.05).Conclusion Therapy of mental rehabilitation combined with family intervention can improve the clinical curative effect of schizophrenia patients, and improve the patient's self -efficacy and quality of life.It is worthy of clinical popularization and application.

Objective We discussed the influence of diary therapy for out-of-hospital rehabilitation of schizophrenia patients with first hospitalization. Methods Ninety schizophrenia patients with first hospitaliza-tion and who were during rehabilitation period were randomized into the intervention group and the control group with 45 cases in each group.The two groups both received systemic antipsychotics medication.The control group adopted general health education while the intervention group got diary therapy based upon general health education.The treatment effect was evaluated by medical and nursing staff with abundant experience using the self-medication compliance questionnaire,the brief psychiatric rating scale(BPRS)and social disability screening schedule(SDSS)at the first day,6th month and first year after intervention. Results The total score of BPRS,SDSS,medication compliance and relapse rate in the intervention group was statistically better than those of the control group. Conclusions Diary therapy could facilitate the recovery of racial function,improve the medica-tion compliance,reduce the relapse rate and increase life quality for schizophrenia patients.

During medical rescue for nuclear and radiation accidents, triage of potential victims could contribute to better use of medical resources currently and higher efficiency of the rescue.Biological dose estimation techniques ( estimated biodosimetry) are effective for assessing the degree of external radiation injury.The application of estimated biodosimetry to triage is important for effective nuclear accident medical rescue.In this paper, the characteristics of the estimated biodosimetry and its application to triage during medical rescue for nuclear accident and radiation were discussed.

Objective : To investigate the effects of C-type lectin domain family 5，member A( CLEC5A) on the pro- liferation，apoptosis，and cell cycle of leukemia cell lines THP-1 and K562，and the underlying mechanism． Methods : The expression of CLEC5A in leukemia patients was investigated in the GEPIA database. Recombined plasmid containing CLEC5A was transfected into THP-1 and K562 cells for overexpression of CLEC5A．Small interfering RNA(siRNA) was used to knock down the endogenous CLEC5A in leukemia cells．CCK-8 and EdU assays were used to assess the leukemia cells proliferation．Flow cytometry was used to assess cell cycle．Flow cytometry was used to assess cell apoptosis under hydrogen peroxide( H2 O2 ) stress．The RNA sequencing( RNA-seq) and pathway enrichment analysis were used to analyze the signal pathways of significant enrichment of up-regulated or down-reg- ulated genes after knocking down CLEC5A gene．Protein expression levels of several members in AKT1 / mTOR and p53 signaling pathways were detected by Western blot assays. Results : CLEC5A was significantly up-regulated in bone marrow tissues of leukemia patients compared to the matched non-tumor tissues of healthy individuals．Knock- down of CLEC5A significantly reduced the proliferation(all P＜0. 01) and S phase progression(all P＜0. 05) ，and increased the apoptosis(all P＜0. 001) under H2 O2 stress，in THP-1 and K562 cells．Conversely，overexpression of CLEC5A significantly increased the proliferation(all P ＜0. 001) and S phase progression ( all P ＜0. 01) ，and re- duced the apoptosis(all P＜0. 01) under H2 O2 stress，in THP-1 and K562 cells．The uregulated genes were sig- nificantly enriched in AKT1-mTOR and other signal pathways after knocking down CLEC5A，while the down-regula- ted genes were significantly enriched in cell cycle signal pathways．CLEC5A in leukemia cells significantly reduced the genes expression levels of BAX and p53，and significantly induced the gene expression levels of BCL-2 and phosphorylation levels of AKT1 and mTOR proteins． Conclusion CLEC5A increases the cell cycle and proliferation and inhibits cells apoptosis in THP-1 and K562 cells，and the mechanism may be related to activating the AKT / mTOR and p53 signaling pathways.