To evaluate the influence of combined endurance and strength training on the knee flexors and extensors strength of Chinese army male recruits. At the beginning and end of their 4 weeks′ combined endurance and strength training, twenty recruits received isokinetic dynamometer test for flexors and extensors of both knees with the Cybex 6000 isokinetic dynamometer. after training, there was a significant increase in the peak torque values, torque acceleration energy, and endurance ratio of flexors of both knees at two angular velocities (60?/s,180?/s). Meanwhile, the torque acceleration energy and endurance ratio were increased in the extensors of both knees at two angular velocities . It suggested that four weeks of combined endurance and strength training for the recruits is effective in terms of increasing muscular strength, explosive force and muscular endurance of knee flexors and extensors. More loads should be applied to strengthen the strength of the extensors.

To evaluate the influence of combined endurance and speed training on the knee flexors and extensors strength of army male recruits. At the beginning and end of their 4 week combined endurance and speed training, twenty recruits received isokinetic dynamometer test of flexors and extensors of both knees with the Cybex 6000 isokinetic dynamometer. The results showed: that there was a significant increase in the peak torque values, torque acceleration energy and endurance ratio of left knee flexors at high angular velocities (180?/s) after training. Meanwhile, the peak torque and endurance ratio were increased in left knee extensors at high angular velocities (180?/s),and the peak torque and torque acceleration energy were increased in right flexors at high angular velocities(180?/s). These data suggest that four weeks of combined endurance and speed training for recruits is not sufficient fo increase muscular strength, explosive force or muscular endurance of knee flexors and extensors.

Objective To evaluate the influence of intensified and step-by-step training on the strength of the knee flexors and extensors in Chinese army male recruits. Methods At the beginning and end of their 8-week endurance training, 160 recruits received isokinetic dynamometer tests for both knees flexors and extensors with the Cybex-6000 isokinetic dynamometer. Results After endurance training, there was a significant increase in the peak torque values, torque acceleration energy, and endurance ratio of both knee flexors at two angular velocities (60 /s,180 /s). Conclusion Eight weeks of recruit intensified and step-by-step training for male recruits is sufficient for increasing muscular strength, explosive force and muscular endurance of knee flexors and extensors.

[Objective]To review the antitumor progress of Raddeanin A in nearly 10 years. [Method] Col ecting the antitumor research literature about Raddeanin A for nearly 10 years, describing its antitumor research mechanism, such as inducting of cellapoptosis blocking the cellcycle, blocking STATs signaling pathways and inhibiting the tumor angiogenesis. [Result] Raddeanin A could induce the H460 cellapoptosis, block LoVo cellcycle and STATs signaling pathways of LoVo cells, and inhibit HepG-2 cellangiogenesis. [Conclusion] The antitumor mechanism of Raddeanin A could be inducting of cellapoptosis, blocking the cellcycle, blocking STATs signaling pathways and inhibiting the tumor angiogenesis.

AIM:To evaluate the efficiency of vitrectomy combined with inferior scleral buckling for a special kind of retinal detachment.
METHODS: Nineteen eyes of special retinal detachment had following features: 1 ) the course was more than 6mo;2) there were at least one hole located in the 5 : 00 - 7 : 00 of the marginal retina; 3 ) the detachment range of retina more than 270 degrees and retinal proliferation in retinal detachment. The 19 eyes who received vitrectomy combined with inferior scleral buckling, retinal anatomic reattachment and visual function recovery was observed.
RESULTS: Among these 19 eyes, all eyes retinal anatomic reattachment and best corrected visual acuity ( BCVA ) was improved in various degrees. The BCVA was 0. 01-0. 1 in 5 eyes, 0. 12-0. 3 in 9 eyes, and ≥0. 4 in 5 eyes.
CONCLUSION: It is an effective method to vitrectomy combined with inferior scleral buckling for the special kind of retinal detachment which has following features:1) the course was more than 6mo;2) there were at least one hole located in the 5:00-7:00 of the marginal retina;3 ) the detachment range of retina more than 270 degrees and retinal proliferation of cable in retinal detachment.

Objective To study the MRI features of sporadic Creutzfeldt-Jakob disease(sCJD). Methods Three patients with clinically diagnosed sCJD underwent MR study,including SE T_1WI,FSE T_2 WI,and DWI sequences.The MR imaging features were analyzed.Results The lesions were not definite either in SE T_1 WI or in FSE T_2 WI,but were prominent in DWI.Abnormal hyperintensive signal appeared in the cerebral cortex,with the frontal,parietal,and occipital lobes being the mostly involved region.The subcortical white matter was normal.The bilateral caudate nuclei and thalami could also be involved.The abnormal signal could be either symmetrical or asymmetrical.There was diffuse atrophy of the brain parenchyma in the late phase of disease,especially in the cortex.Conclusion With the application of MR study,especially the DWI,combined with its characteristic clinical manifestation,the diagnosis of sCJD can be made definitely.

This paper presents a high voltage generator for the defibrillator.Its principle and design method are introduced.The high voltage generator is the core part of the defibrillator which is necessary toany hospital.There is nodomestic-patented defibrillator by now and published paper specialized in the principle and design method of the high voltage generator for the defibrillator.

Objective To investigate the role of extracellular signal-regulated kinase in neuronal apoptosis of hippoeampus induced by global cerebral ischemia-reperfusion in rats.Methods Ninety healthy male SD rats weighing 280-320 g were randomly divided into 3 groups(n=30 each):groupI sham operation(S);groupⅡI/ R and group Ⅲ PD98059+I/R(PD).The animals were anesthetized with intraperitoneal 1% pentobarbital 40 mgkg.Global cerebral I/R was produced by 4-vessel occlusion method.Bilateral vertebral arteries were electrically cauterized and bilateral common carotid arteries were clamped for 5 min.Clamping was then released for reperfusion in group Ⅱ and Ⅲ.In group Ⅲ PD98059(a specific ERK inhibitor)O.3 mg/kg was injected iv before carotid artery clamping.Five animals in each group were sacrificed at 2,6,12,24,48 and 72 h of reperfusion and their brains were removed and cut into sections which were stained with HE and examined under microscope(400 times magnified).Neuronal apoptosis in hippieampal Cal and CA3 regions were detected by TUNEL assay.Apoptotic index(AI) was calculated.Phosphorylated ERK(p-ERK)and phosphorylated Bad (p-Bed)expression was assessed by immuno-histochemistry.Results (1)Hippoeampal pyramidal cells were orderly distributed and morphologically intact in group S but unevenly distributed with widened intercellular space,shrinked cell body and condensed nuclei in I/R group.The I/R induced changes were worse in PD group.(2)AI in Cal and CA3 region was significantly higher in PD group than in I/R group.(3)The p-ERK expression in Cal region was signiticanfly decreased at 2,6,12 h of reperfusion in I/R(Ⅲ)and PD groups(Ⅲ)as compared with group S(I),while p-ERK expression in CA3 region was significantly lower at 2,6,12,24 h of reperfusion in PD group(Ⅲ)than in S(I)and I/R group(Ⅱ).(4)The p-Bed expression in Cal and CA3 regio was signi ficantly lower during reperfusion in PD group than in I/R group and was lowest in group S(I).Conclusion Cerebral isehemia reperfusion can decrease the p-ERK expression and then leads to the dephosphorylation of Bed(a member of Bel-2 protein family),which induced the apeptosis in hippoeampal neurons.

Objective To establish the method of fingerprint analysis on Yupingf eng Decoction,and to study the correlation of HPLC fingerprint in Radix Astraga li,Radix Saposhnikovlae,Rhizoma Atractylodis Macrocephalae and Yupingfeng Deco ction. Methods HPLC with Hypersil ODS was used,acetonitrile -water(gradient el ution) as a mobile phase and detection wavelength at 220 nm,flow rate was 1 mL ?min-1,and column temperature was 30 ℃. Results There were 9,8 and 7 common peaks separated from 10 batches of medicinal material of Radix Astragali,Radix Saposhnikovlae,and Rhizoma Atractylodis Macrocephalae,respectively;11 common peaks were separated from 10 batches of Yupingfeng Decoction,of which 6 peaks were shared by Radix Astragali,4 peaks by Radix Saposhnikoviae and 1 peak by Rh izoma Atractylodis Macrocephalae. Conclusion There exists a correlation of Yupin gfeng decoction with the medicinal pieces of Radix Astragali and Radix Saposhnik oviae. The major characteristic fingerprint peaks of Yupingfeng decoction belong to those of the isoflavones from Radix Astragali and chromones from Radix Sapos hnikoviae. This will provide a reference for the rules of the compatibility and component research of Yupingfeng Decoction.

AIM:To establish the method of fingerprint-analyzing Herba pogostemonis by HPLC,and compare the variability of the different parts,including stems and leaves,which could be used for quality evaluation of Herba pogostemonis. METHODS: HPLC with Hypersil ODS column was used,the acetonitrile-0.05% phosphoric acid(gradient elution)as a mobile phase and detection wavelength was at 320 nm,column temperature was at 30 ℃,and flow rate was 1.0 mL/min. RESULTS: 16 common peaks were separated on HPLC fingerprint in the stems and leaves of Herba pogostemonis,there was significant variability between the stems and leaves,the content in the leaves was more than in the stems. CONCLUSION: The method is reliable,accurate and provides a reference for the quality control of Herba pogostemonis.