2.Controlled observation of clinical efficacy on knee osteoarthritis treated with auricular electroacupuncture and the isolated moxibustion with Lingxian herbal paste.
Gang CHENG ; Wei CHENG ; Yong-Gui JIANG
Chinese Acupuncture & Moxibustion 2014;34(3):230-234
OBJECTIVETo observe the difference in the therapeutic effects on knee osteoarthritis (KOA) among auricular electroacupuncture therapy plus isolated moxibustion with Lingxian herbal paste (combined therapy), electroacupuncture (EA) and TDP irradiation.
METHODSEighty-nine cases were randomized into three groups. In the combined therapy group (30 cases), the auricular electroacupuncture therapy was adopted together with the isolated moxibustion with Lingxian herbal paste. The auricular points were xi (AH4), pizhixia (AT4), shenmen (TF4), etc. The Lingxian herbal paste was applied at Yanglingquan (GB 34), Dubi (ST 35), Zusanli (ST 36), Neixiyan (EX-LE 4), Heding (EX-LE 2) and Ashi points. In EA group (29 cases), EA was applied at the acupoints that were same as those in the isolated moxibustion with Lingxian herbal paste. In TDP group (30 cases), TDP irradiation was given at the affected knee. The treatment was given once every day, 10 treatments made one session and there was 1 week at the interval among sessions. Totally, 3 sessions of treatment were required. KOA clinical symptom and physical sign score and the single item pain symptom score of Lequesne index were observed before treatment and 1 week after treatment in the patients of each group separately. The efficacies were compared among the three groups.
RESULTSOne week after treatment, the total score of symptoms and physical signs of the patients in each group was reduced significantly as compared with that before treatment (all P < 0.05). The improvements in the symptoms and physical signs in the combined therapy group were better than those in the other two groups (1.50 +/- 1.57 vs 2.52 +/- 1.82, 2.63 +/- 1.97, both P < 0.05). The improvement in pain in the combined therapy group was also better than that in the other two groups (2.37 +/- 0.81 vs 2.83 +/- 0.92, P < 0.05; 2.37 +/- 0.81 vs 3.03 +/- 0.77, P < 0.01). The curative rate in the combined therapy group was 40.0% (12/30), which was higher than 17.2% (5/29) in EA group and 20.0% (6/30) in TDP group separately (both P < 0.01). The overall efficacy in the combined therapy group was superior to the other two groups (P < 0.05).
CONCLUSIONThe auricular electroacupuncture therapy plus isolated moxibustion with Lingxian herbal paste is advantageous at the total score of the symptoms and physical signs and the overall efficacy in the patients of KOA as compared with EA at the local acupoints and local TDP irradiation.
Aged ; Combined Modality Therapy ; Drugs, Chinese Herbal ; administration & dosage ; Electroacupuncture ; Female ; Humans ; Knee Joint ; drug effects ; Male ; Middle Aged ; Moxibustion ; Osteoarthritis, Knee ; drug therapy ; therapy ; Treatment Outcome
3.Recent advances in molecular pathology of classic Hodgkin's lymphoma.
Gang AN ; Hui-shu CHEN ; Lu-gui QIU
Chinese Journal of Pathology 2010;39(2):133-136
Cell Proliferation
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Cell Transformation, Neoplastic
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Epigenesis, Genetic
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Hodgkin Disease
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genetics
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immunology
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metabolism
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pathology
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Humans
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Immunophenotyping
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NF-kappa B
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metabolism
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Receptor, Notch1
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metabolism
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Reed-Sternberg Cells
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immunology
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metabolism
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pathology
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Transcription Factor AP-1
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metabolism
4.Study on Nerve Growth Factor in Promoting Muscular Neurotization of Denervated Vascularized Skeletal Muscle
gang, SU ; gui-lin, LIU ; yan, WANG
Journal of Applied Clinical Pediatrics 1994;0(04):-
Objective To investigate the effect of nerve growth factor(NGF)in the process of muscular neurotization of denerva- ted vascularized skeletal muscle.Method By using NGF(0.5 ?g/d) to transplanted skeletal muscle,muscular neurotization was exa- mined with histological,histochemical,electron microscope and immunohistochemical methods at various time.Result NGF was effective in promoting muscular neurotization and diminishing denervated muscle atrophy in grafted denervated skeletal muscle.Conclusion NGF can promote the muscular neurotization and diminish denervated muscle atrophy.
6.From head and neck surgery to head and neck oncology: the disciplinary guarantee for comprehensive cancer therapy.
Gui-yi TU ; Zhen-gang XU ; Shao-yan LIU
Chinese Journal of Oncology 2009;31(11):877-879
Combined Modality Therapy
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Head and Neck Neoplasms
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drug therapy
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pathology
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radiotherapy
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surgery
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Humans
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Hypopharyngeal Neoplasms
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radiotherapy
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surgery
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Medical Oncology
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education
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Nasopharyngeal Neoplasms
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radiotherapy
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surgery
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Neoplasm Staging
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Otorhinolaryngologic Surgical Procedures
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education
8.Influence of Wnt signaling pathway on mouse NIT-1 β-cell cultured in vitro
Shuyan GUI ; Muxun ZHANG ; Lili ZHOU ; Yikai YU ; Gang YUAN
Chinese Journal of Endocrinology and Metabolism 2010;26(8):707-710
Objective To establish whether Wnt-signaling pathway plays a role in mice β-cell function and/or survival in vitro. Methods Mice NIT-1 beta cells were cultured in media with glucose concentration of 33.3 mmol/L and the cytokines interleukin-1β, interferon-γand tumor necrosis factor-α with or without the addition of purified Wnt3a protein in vitro. Subsequently, β-cell apoptosis by Tunnel and flow cytometry, and β-cell proliferation by BrdU were analyzed. Total RNA was extracted to measure gene expressions by real-time PCR.Results Incubations of NIT-1 cells with high glucose and cytokines resulted in an increase in β-cell apoptosis and decrease in β-cell proliferation (P<0.01). In contrast, treatment with Wnt3a protein protected β-cell from glucose and cytokines-induced apoptosis through up-regulating the expressions of above Pitx2、 TCF7L2. Conclusions Wnt-signaling regulates the proliferation of pancreatic β-cell, and protectes β-cell from glucotoxicity and cytokine toxicity with respect to proliferation and apoptosis.
9.Influence of Wnt signaling pathway on peroxisome proliferator-activated receptor γ and glucokinase expression in mice NIT-1 β-cell cultured in vitro
Bowen ZHOU ; Hanqiang REN ; Shuyan GUI ; Gang YUAN
Chinese Journal of Endocrinology and Metabolism 2014;30(11):990-994
Objective To investigate the expression of peroxisome proliferator-activated rec eptor γ (PPARγ) and glucokinase (GK) induced by Wnt signaling pathway in mice NIT-1 β-cells,and to explore the interaction between PPARγ and Wnt signaling pathways.Methods Recombinant Wnt3a protein was applied to NIT-1 beta-cells to activate Wnt signaling pathway.The expression of PPARγ was determined by real-time PCR and Western blotting.The expression of GK was determined by real time PCR.Results Wnt3a rapidly activated Wnt/β-catenin/TCF signaling pathway,and increased PPARγ and GK mRNA expression by 41.2% and 65.0% in NIT-1cells,with PPARγ protein expression increasing by 97.8% (P<0.01).These effects were abrogated by Wnt and PIK3 inhibitors,dickkopf 1 and wortmannin treatment (P< 0.01).Conclusions PPARγ and GK can be upregulated by Wnt singnaling,and the effects might partially be PI3K-dependent.
10.Pros and cons of total thyroidectomy.
Zhen-gang XU ; Shao-yan LIU ; Gui-yi TU
Chinese Journal of Oncology 2011;33(7):554-555