Humans ; Male ; Middle Aged ; Neoplasms, Radiation-Induced ; etiology ; Occupational Diseases ; etiology

Carcinogens ; chemistry ; toxicity ; Chromium ; chemistry ; toxicity ; Chromium Compounds ; chemistry ; toxicity ; Humans ; Occupational Exposure ; analysis

Objective To analyze the correlation between chronic inflammation of vocal cords after the union and obstructive sleep apnea hypopnea syndrome (OSAHS),the predictive value to OSAHS.Methods One hundred and fifty-six cases of OSAHS patients underwent polysomnography (PSG) and fiber laryngoscopy,indexing based on the chronic inflammatory of vocal cords after the union.Apnea-hypopnea index (AHI),the lowest blood oxygen saturation and mean oxygen saturation were compared in different degrees patients.Mild,moderate,severe,very severe degree respectively had 32,70,36,18 cases.The patients were treated according to the cause and 1 and 3 months after treatment to determine efficacy.Results Following severity of chronic inflammation of vocal cords after the union,AHI gradually increased before treatment [mild,moderate,severe,very severe degree degree respectively (11.23 ±4.13),(21.23 ± 13.29),(44.53 ± 10.11),(56.56 ± 12.31) times/h],the lowest oxygen saturation and mean oxygen saturation decreased (mild,moderate,severe,very severe degree respectively 0.914 4 ±0.053 1 and 0.955 0 ± 0.041 2,0.834 2 ± 0.098 6 and 0.913 5 ±0.033 2,0.626 8 ±0.090 4 and 0.863 1 ±0.053 2,0.601 1 ± 0.101 1 and 0.752 1 ± 0.040 1),the differences were statistically significant (P ＜ 0.05).One month after treatment,the total effective rate was 75.64％ (118/156),3 months after treatment was 88.46％ (138/156).Conclusion Chronic inflammatory degree of vocal cords after the union is positively correlated with OSAHS,OSAHS patients according to etiological treatment have a significant effect.

Objective To explore the changes of the serum matrix metalloproteinase 9(MMP-9) in coronary artery bypass grafting(CABG) under cardiopulmonary bypass (CPB) and the correlations between the serum MMP-9 and tumor necrosis factor alpha (TNF-α),interleukin 8 (IL-8).Methods Twenty-two patients who subjected to CABG were selected.Artery blood samples were collected at the following time points:before intubation (T0),15 min after initiation of CPB (T1),the end of operation (T2),2 h after operation (T3) and 6 h after operation(T4).The serum MMP-9,TNF-α and IL-8 levels were detected by ELISA and analyzed.Results The serum MMP-9 levels at T1,T2,T3 and T4 were (102.82 ± 19.03),( 428.80 ± 32.91 ),( 305.64 ± 29.75 ),( 157.78 ± 22.18 ) μg/L,respectively,which were significantly higher than that at To [ (38.67 ± 10.15 ) μ g/L] (P ＜ 0.05 ).The serum MMP-9 level gradually increased during CPB and reached the peak at T2,and then decreased.The serum TNF- α and IL-8 levels had the same change as MMP-9,the peak levels at T2 were (287.06 ±24.58),(143.12 ± 16.36) ng/L,respectively.The serum MMP-9 level had positive correlation with TNF- α and IL-8 levels ( r =0.69,0.54,P ＜ 0.05 ).Conclusions CPB can lead to the increased release of MMP-9,TNF-α and IL-8.TNF-α and IL-8 may induce the activation and release of MMP-9.The serum MMP-9 can contribute to the general inflammatory reaction of CPB.

Objective:To discusse some questions and solve method on microecological in the market at present,to uppraised the form and pharmacologic effect.Methods:To gather the directions related to content for clinical often to used preparations.Results:It hasn't unitary standard and expression on every microecological,the effect is close related to the form. The importance of pharmacologic effect is health care and regalating.Conclusion:It must have a quality standard and expression on microecological.

Objective To investigate the complication and its treatment method of the percutaneous nephrolithotomy(PCNL).Methods The clinical data of 137 patients with PCNL,were retrospectively analyzed statistical analysis of complications.Results In 137 cases of PCNL,83 cases were male,54 cases were female; 103 cases of kidney stones,ureteral calculi in 34 cases,including 24 cases of ureteral calculi with renal calculi.All patients were cured,no patients died;complications occurred in 9 cases,in which the puncture failure in 1 case,renal hemorrhage in 5 cases,postoperative arteriovenous fistula in 1 case,infection in 2 cases.Conclusion PCNL is minimally invasive,effective,but still had more serious complications.We should strengthen the prevention and cure measures.

Alpha-fetoprotein (AFP) was first discovered over 50 years ago, and is currently applied clinically in diagnosis, effects evaluation and relapse judgement of tumors especially for the primary hepatocellular carcinomas.And as an effective tumor marker, AFP test has become one of the essential items in physical examination.However, its clinical application is not limited to primary hepatocellular carcinomas,and its great application value has been proved in many benign diseases and other tumors (non-hepatic carcinomas).

The incidence of gastroesophageal junction cancers is rapidly increasing, the Year' s upwards rate being more than 5％ ～ 10％. Siewert in 1987 proposed a definition for adenocarcinoma of the esophagogastric junction (AEG), as a adenocarcinoma within 5 cm of the gastroesophageal junction (GEJ), and divided AEG in to three types. The majority of patients with AEG in Asian countries have type Ⅱ and Ⅲ cancers, and no obvious differences have been reported in 5-year survival rates between patients with different types of AEG. In contrast, in western countries, the distribution of each type of AEG is nearly equal,patients with AEG type Ⅰ cancer have the best prognosis, whereas the overall survival of patients with type Ⅲ cancer is the worst. Now people presume that the AEG is a special type of carcinoma which is not same as carcinoma of esophagus and stomach. The surgical routes and operative methods and the extent of lymph node dissection of AEG are still not completely clear, and AEG lacks also a independent TNM system for itself. We will summarize the actuality of diagnosis and therapy of AEG.

Objective To summarize the endoscopic characteristics of Primary Gastrointestinal Malignant Lymphoma (PGIML) and increase the diagnostic accuracy of this method to aid the clinical treatment.Methods The clinical data of 67cases with PGIML from 2004 to 2009 were studied retrospectively.ResultsPGIML lacked specific clinical symptoms.The main clinical symptoms were abdominal pain, melena and abdominal mass.In our study, most PGIML(37/67,55.8％)were detected in stomach.Nodular appearance of mucosal surface was the most common endoscopic finding.The positive rate of endoscopic biopsy for the diagnosis of PGIML was 68.7 ％ (46/67 biopsy cases).All cases had Non-Hogkin Lymphoma (NHL).The most common immunophenotype was B-cell majority (50/67).Thirty cases had MALT.ConclusionIt is hard to diagnose PGIML at early stage,combination of various diagnosis tests should be considered to solve this problem.The effectiveness of surgery on PGIML should be further confirmed by prospective randomized clinical trials.

Objective To investigate the effects of fresh isolated platelets combined with hemocoagulase on treating and preventing rehaemorrhagia after operation in the patients with cerebral hemorrhage who treated with aspirin.Methods Forty-six patients with cerebral hemorrhage who treated with aspirin were divided into combined therapy group(n =23) and simple therapy group(n =23).Eighteen patients with no aspirin treated were as control group.All patients were received the same basic treatment of small bone flap craniotomy and hemocoagulase.Moreover,patients in combined therapy group were treated with fresh isolated platelets before and after operation.The remained haematoma volume,the volume of draining,platelect aggregation rate,platelet adhesion rate,prothrombin time and activated partial thromboplastin time were measured before and after treatment respectively.Results Before treatment,the haematoma volume were(53 ± 11) ml,(51 ± 13) ml,(50 ± 15) ml in combined therapy group,basic therapy group and control group respectively,and no significant difference was found among the three groups(F =0.29,P ＞0.05).The rate of platelet aggregation and the rate of platelet adhesion in combined treatnnet group were (43.6 ± 6.2) ％ and (41.6 ± 8.5) ％,and (43.1 ± 5.0) ％,(42.7 ± 8.9) ％ in simple group,significantly lower than that in control group ((65.2 ± 6.1) ％,64.3 ±9.1) ％.F =92.93,40.93,P ＜0.05)).At 1st day after treatment,the remained haematoma volume and the volume of draining in combined therapy group were(7 ±4) ml and (301 ±21) ml,significantly lower than that in simple therapy group ((19 ± 5) ml,(413 ± 26) ml,P ＜ 0.05).While the rate of platelet aggregation (64.8 ±5.7)％ and the rate of platelet adhesion(63.3 ±6.6)％ in combined therapy group were significantly higher than that in simple therapy group ((51.6 ± 3.7) ％,(50.3 ± 7.8) ％,P ＜ 0.05).And compared to control group ((68.1 ± 5.9) ％,(67.4 ± 9.5) ％),there were no significant difference between combined therapy group and control group (P ＞ 0.05).Conclusion Fresh isolated platelets combined with hemocoagulase can improve the function of blood clotting and reduce rehaemorrhagia after operation in the patients with cerebral hemorrhage who treated with aspirin.