Acupuncture Points ; Adolescent ; Adult ; Bloodletting ; Female ; Humans ; Male ; Middle Aged ; Psoriasis ; therapy ; Young Adult

Animals ; Disease Models, Animal ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; Female ; Heat Stress Disorders ; drug therapy ; metabolism ; Hypothalamus ; metabolism ; Male ; Neurotensin ; metabolism ; Phytotherapy ; Rats ; Rats, Wistar ; Tablets

Humans ; Male ; Middle Aged ; Neoplasms, Radiation-Induced ; etiology ; Occupational Diseases ; etiology

Carcinogens ; chemistry ; toxicity ; Chromium ; chemistry ; toxicity ; Chromium Compounds ; chemistry ; toxicity ; Humans ; Occupational Exposure ; analysis

Objective:To explore the treatment for the esophagus stricture after esophageal burn.Methods:The aiming steel-wire was put in stomach and Savary-Gilliard dilator was penetrated into the steel-wire,then the stenotic segment of the esophagus was dilated with the dilator.Results:Amang 29 of 31 cases patients,after the dilatation for 3～14 times,all of them could take in ordinary food,and propotional dilator could go through their the segment of the esophageal stenosis.The effect of the barium meal examination disclose was good.Conclusion:The dilatation of esophagus is a simple,safe method with few neopathy for the esophagus stricture of after esophageal burn.

Alpha-fetoprotein (AFP) was first discovered over 50 years ago, and is currently applied clinically in diagnosis, effects evaluation and relapse judgement of tumors especially for the primary hepatocellular carcinomas.And as an effective tumor marker, AFP test has become one of the essential items in physical examination.However, its clinical application is not limited to primary hepatocellular carcinomas,and its great application value has been proved in many benign diseases and other tumors (non-hepatic carcinomas).

Objective To evaluate the effect and safety ofotoscopic myringoplasty and microscopic myringoplasty.Methods PubMed,CNKI,VIP database and Wanfang database were searched to identify citations mentioned otoscopic myringoplasty or microscopic myringoplasty.In addition,manual collection of clinical study of related reviews and its references were also conducted.Inclusion criteria of the ordinance made Meta analysis.Results A total of 15 clinical studies with 915 patients (otoscopic group was in 691patients and microscope group was in 224 patients) was identified.According to Q test,there was no heterogeneity between 2 groups (I2 =0),all computed by fixed effects model.Meta analysis demonstrated that there was no significant difference between 2 groups on the type of perforation (OR =1.00,95％ CI:0.70-1.42,P =0.13).Both curable rate and enhance of air conduction had no significant difference between 2groups (OR =0.97,95％ CI:0.72-1.29,P=0.97;OR =1.14,95％ CI:0.68-1.91,P=0.96).The curable rate in otoscopic group was 0.92 (95％ CI:0.90-0.94),and the complication rate was 0.030 (95％ CI:0.009-0.051).Conclusions The available clinical evidence shows that there is no significant difference between otoscopic myringoplasty and microscopic myringoplasty.However,otoscopic myringoplasty should be recommended to perform in clinical practice because of the feasible and convenient procedure.

Objective To study the effects of different postoperative analgesia on the postoperative stress and cellular immune function in patients undergoing total hysterectomy.Methods Seventy-five patients undergoing total hysterectomy were divided into three groups by table of random digit with 25 cases each:morphine patient controlled epidural analgesia (PCEA) group (group A),tramadol PCEA group (group B) and butorphanol tartrate preemptive analgesia combined with tramadol PCEA group (group C).Peripheral venous blood samples were taken before anesthesia,the end of operation,1 and 3 d after operation for the serum levels of cortisol,norepinephrine (NE),epinephrine (E) and T-lymphocyte subsets (CD4+,CD8+).Results The serum levels of cortisol at the end of operation and 1,3 d after operation in group A and B had significant difference compared with those before anesthesia (P ＜ 0.05),the serum level of cortisol at 1d after operation in group C had significant difference compared with that before anesthesia (P ＜ 0.05).Compared with those before anesthesia,in the 3 groups,there were significant differences in the serum levels of E at the end of operation and 1 d after operation and the serum levels of NE at the end of operation and 1,3 d after operation (P ＜0.05).Compared with the same time of group A and B,there were significant differences in the serum levels of cortisol and E at 1 d after operation and the serum levels of NE at 1,3 d after operation in group C (P ＜ 0.05).CD4+,CD4+/CD8+ at the end of operation and 1,3 d after operation in 3 groups were significantly lower than those before anesthesia (group A:0.266 ±0.034,0.226 ±0.029,0.256 ±0.031 vs.0.313 ±0.030 and 1.3 ±0.3,1.0 ±0.1,1.1 ±0.2 vs.1.5 ±0.2,group B:0.271 ±0.031,0.242 ± 0.027,0.261 ± 0.030 vs.0.311 ± 0.034 and 1.3 ± 0.2,1.1 ± 0.1,1.2 ± 0.1 vs.1.5 ± 0.1,group C:0.282 ±0.036,0.276 ±0.030,0.290 ±0.028 vs.0.314 ±0.032 and 1.4 ±0.2,1.3 ±0.1,1.4 ±0.1 vs.1.5 ± 0.2,P ＜ 0.05).There were significant difference in CD4+ and CD4+/CD8+ 1,3 d after operation of group C than those of group A and B (P＜ 0.05).There was no significant difference in CD8+ among the 3 groups (P＞0.05).Conclusion Butorphanol tartrate preemptive analgesia combined with tramadol PCEA may reduce postoperative stress response and immune depress,compared with only morphine or tramadol PCEA.

Congenital heart disease is the most common birth defect.With the significant improvements of cardiac surgical techniques,the survival of newborns and infants with complex congenital heart disease(CHD) has obviously been increased.However,neurological sequelae are still common and up to 25 ％ ～50％.The most important lesion after CHD surgery is white matter(WM) injury.Recent studies show that periventricular leukomalacia disease characterized by WM injury is common in C-HD infants especially after cardiac surgery.It is previously thought to be due to the cardiopulmonary bypass and surgical operation.However,with the advances in surgery and medical diagnostic technology and development of basic research in recent years,it is discovered that WM injury in infants with CHD is a complex lesion influenced by preoperative,operating and postoperative factors.The movement disorders and the defects of attention,learning and other aspects in the late growth of these children bring a huge economic burden to the family and society,reducing the quality of the population.Therefore,exploring etiology,mechanisms and control methods of WM injury in infants with CHD becomes a hot topic in recent years,and it may also become an important direction for future research,aiming to the significant improvements in CHD children with neurodevelopmental damages.

Objective To observe the efffects of angiotensin Ⅱ receptor antagonist (ARB) valsartan in decreasing blood pressure and protecting kidney to the patients suffering from mild-or-moderate hypertension companied with earlier type 2 diabetic nephropathy. Methods The patients suffering from mild-to-moderate hypertension and earlier type 2 diabetic nephropathy were divided into two groups. One of the groups were treated by valsartan, and the other were treated by betaloc and aldadinc. The period of the treatment and doses of the medicines were adjusted depending on the blood pressure 4 weeks later. The therapeutic effects of the two medicines were analyzed 6 months later. Results There was no difference in the effects of decreasing blood pressure and side-effects between the two groups. There are marked discrepancy between the two groups in the post-trearment 24h urinary albumin excretion rate (UAER) and the variation of 24h UAER (all P<0.05). There was no significant difference in others parameters (all P0.05). Conclusion Valsartan could prevent early proteinuria of type 2 diabetic nephropathy from developping and protect the function of kidney.