Objective To explore the correlations of between expectations and anxiety and depression of cervical cancer patients. Method Herth hope index,self-rating anxiety scale(SAS)and self rating depression scale(SDS)and self-made general information questionnaire were used to investigate the levels of hope,anxiety and depression as well as the correlations between them.Results The overall level of hope in cervical cancer patients was(36.89±4.21)in a moderate to high level. The scores on hope level and keeping intimate relationships with other in the group of patients,aged above 50 years,married,with high school education or above and monthly income of 1,500 yuan were significantly higher than those of the other group patients.The incidences of anxiety and depression were 47.83%and 52.17%, respectively. The general hope level and its three dimensions was negatively related to the anxiety and depression(P<0.01).Conclusions The hope of cervical cancer patients are at moderate to high level and are negatively correlated between anxiety and depression.Improving the hope level of cervical cancer patients can effectively improve patients bad feelings.

Objective To explore the value of cervical lesions screened with white acetate solution. Methods Four hundred and eighty-five patients who were suspected with cervical lesion during Janurary to March 2016 were enrolled in this study. The patients were asked about the medical history, filled the registration form, and performed routine gynecological examinations with white acetate solution, thinprep cytology test (TCT) and vaginal endoscopic biopsy. The value of white acetate solution in clinic was assessed. Results In 485 patients, 450 patients (92.78%) were pathologically diagnosed of inflammation (92.78%), 24 patients (4.95%) were diagnosed of low-grade squamous intraepithelial lesion (LSIL), 10 patients (2.06%)were diagnosed of high-grade squamous intraepithelial lesion (HSIL), and one patient (0.21%) was diagnosed of cervical cancer. The detection rate of white acetate solution and TCT were gradually increased with the increase of the degree of cervical lesions. The detection rate of white acetate solution in the inflammation was 1.33%, in LSIL was 91.67%, in HSIL was 9/10, and in cervical cancer was 1/1. The detection rate of TCT in the inflammation was 8.44%, in LSIL was 66.67%, in HSIL was 6/10, and in cervical cancer was 1/1. The sensitivity, specificity and coincidence rate of the diagnostic results with white acetate solution were 84.21%, 99.33%, 98.14%, and with TCT were 62.30%, 93.63%, 89.69%. There were significant differences (P<0.05). Conclusions Cervical lesions screened with white acetate solution is good in sensitivity and specificity, which is an effective way for screening cervical cancer.

Objective To investigate the curative effect and adverse reaction of caffeic acid (CFA) for leukopenia and thrombocytopenia caused by imatinib in chronic myeloid leukemia (CML) patients.Methods The effect and adverse reactions of CFA for leukopenia or thrombocytopenia induced by imatinib in 42 CML patients were observed.The CFA was admitted by 0.2 g/time,3 times/d,oral.Results 21 cases of 42 CML patients with thrombocytopenia achieved remarkable curative effect after CFA treatment,13 achieved good effect and 8 had no effect.The total effective rate was 81.0 ％ (34/42).While 15 of 28 leukopenia CML patients achieved remarkable curative effect,8 achieved good effect and 5 had no effect.The total effective rate was 82.1％ (23/28).After CFA therapy for 2 weeks,both platelet and white blood cells count were elevated compared with before treatment,the differences were statistically significant (t =2.015,P =0.023,t =1.913,P =0.035).The average onset time of CFA for leukopenia and thrombocytopenia was 2 weeks and no treatment-related adverse reaction was found.Conclusion CFA is an effective and safe auxiliary drug for treatment of imatinib-induce leukopenia and thrombocytopenia in patients with CML.

control, P

Objective To analyze the effect on reproductive potential of salpingectomy in child-bearing period women.Methods Two hundred and forty-six tubal pregnancy patients were chosen,among whom 164 patients performed salpingectomy were classified as research group,and 82 patients retained ipsilateral tubal through conservative treatment were classified as control group.The levels of sex hormone,ovarian volume,sinus number of follicle,ovulation rate,reproductive outcome and reproductive status were compared between 2 groups.Seven patients were lost in research group,and 3 patients were lost in control group.Results One,three and six months after β-human chorionic gonadotrophin (β-hCG) put back,the serum levels of follicle stimulating hormone (FSH),luteinizing hormone (LH) in research group were significantly higher than those in control group,FSH:(10.00 ±4.82) U/L vs.(6.69 ± 2.71) U/L,(9.11 ± 3.77)U/L vs.(6.81 ± 2.80) U/L,(8.30 ± 3.49) U/L vs.(6.41 ± 2.41) U/L;LH:(8.74 ± 3.56) U/L vs.(6.10 ± 2.59)U/L,(9.42 ± 3.09) U/L vs.(5.79 ± 2.10) U/L,(7.96 ± 2.53) U/L vs.(6.50 ± 2.71) U/L,and there were statistical differences (P ＜ 0.05).One and three months after β-hCG put back,the serum levels of estradiol (E2) and anti-Mullerian hormone (AMH) in research group were significantly lower than those in control group,E2:(111.44 ± 22.24) pmol/L vs.(128.22 ± 24.01) pmol/L,(108.74 ± 21.67) pmol/L vs.(126.30 ± 23.78) pmol/L;AMH:(3.22 ± 0.85) μ g/L vs.(3.64 ± 0.87) μ g/L,(3.67 ± 0.94) μ g/L vs.(3.83 ± 1.12) μ g/L,and there were statistical differences (P ＜ 0.05).Six months after β-hCG put back,there was no statistical difference in the serum levels of E2 and AMH:(127.85 ± 24.42) pmol/L vs.(131.28 ± 25.54) pmol/L and (4.35 ± 1.34) μ g/L vs.(4.47 ± 1.76) μ g/L,P ＞ 0.05.In salpingectomy patients,the ovarian volume and the sinus number of follicle at lesion side (salpingectomy side) after treatment of 6 months were significantly lower than those in no lesion side:(8.86 ± 2.36) cm3 vs.(9.74 ± 2.31) cm3 and (5.10 ± 1.14) pieces vs.(7.26 ± 2.52) pieces,and there were statistical differences (P ＜ 0.05).After treatment of 2 years,the rate of ectopic pregnancy in control group was significantly higher than that in research group:12.66％ (10/79) vs.5.10％(8/157),and there was statistical difference (P ＜ 0.05).Especially,the patients who retained ipsilateral tubal conservative treatment had higher ectopic pregnancy rate:8.86％ (7/79) vs.0,and there was statistical difference (P ＜ 0.05).Conclusions Salpingectomy can affect the reproductive potential,but it can decrease the probability of ectopic pregnancy.Whether patients with tubal pregnancy need to be treated by salpingectomy,depends on the extent of tubal lesions and fertility desire of the patients.

Objective To compare the risk factors of mild hemorrhage and diiferences of TOAST type in patients with acute cerebral infarction (ACI) and transient ischemia attack (TIA).Methods Forty patients with mild hemorrhage were divided into ACI group(24 cases) and TIA group(16 cases) according to disease classification.Risk factors such as age,blood pressure,blood lipid and so on between 2 groups were compared,TOAST subtype differences of 2 groups were compared.Results The age [(73.3 ± 4.1) years],the ratio of hypertension [95.8％(23/24)],leukoaraiosis [70.8％(17/24)] in ACI group was significantly higher than that in TIA group [(65.5 ± 5.6) years,13/16,9/16],there was significant difference (P ＜ 0.05).The ratio of large-artery atherosclerosis and cardioembolism in ACI group [75.0％ (18/24) and 16.7％ (4/24)] was significantly higher than that in TIA group (8/16 and 1/16),there was significant difference (P ＜ 0.05).But the ratio of small artery occlusion in ACI group [8.3％ (2/24)] was significantly lower than that in TIA group (7/16),there was significant difference (P ＜ 0.05).Conclusion Correlative risk factors of milde hemorrhage in ACI and TIA patients have significant differences.

0.05).Conclusion The elevation of GH involved in the pathogenesis of diabetic microangiopathy possibly by exacerbation of disorders of glucose and lipid metabolism.

Objective To optimize the radioligand assays for glutamic acid decarboxylase antibody (GAD-Ab), tyrosine phosphatase antibody (IA-2A) and insulin autoantibody (IAA) and to facilitate their application in clinical practice. Methods The radioligand assays established in our laboratory were optimized in several aspects, including the mode and time of antigen-antibody incubation, pH value of TBST buffer, times of washing, and type of centrifuge. The sensitivity and specificity of the optimized assays were calculated by the Diabetes Antibody Standardization Program (DASP, 2003). And the results were compared to those measured with domestic radioimmune assay kits. Results The optimal condition for radiligand assay were as followed: incubating the antigens of GAD-Ab and IA-2A with serum by rotating slowly for 24 hours and IAA for 72 hours respectively; washing the precipitation complex of GAD-Ab and IA-2A with TBST buffer (pH value 7 2～7 4) 4 times and IAA 5 times respectively; and applying the horizontal type of centrifuge. The results from DASP demonstrated that sensitivity and specificity of the optimized assays were 82% and 98% respectively for GAD-Ab, and 64% and 100% for IA-2A. The proportion of consistency between our results for 82 IAA gradient index of optimized assay and those measured with domestic radioimmune kits was 89%. The extensive analysis showed that the consistency reached 100% for those with IAA index less than 0 04 or more than 1 00, and the inconsistency was for the bordline positive ones (index 0 04～1 0). Conclusion The optimized radioligand assays for islet autoantibodies are high sensitivity and specificity, and are applicable in clinical practice.

ObjectiveTo investigate the children with cerebral palsy (CP) in rehabilitation, their families and need of society support. Methods150 children with CP in rehabilitation participated in this study. A questionnaire was designed to investigate their basic situation, family status, society concern and requirements for society support, which completed by their parents. Results150 questionnaires were completed efficiently. 75 children were firstly treated before 1 year old. The rehabilitation treatments were effective to 130 children. 126 children appeared some disorder in emotion and personality. Home education was the main rehabilitation way in 133 children. The educational background of 59.4% mothers were senior high school or below. The income was less than 60 thousand yuan in 76.7% families, but spent more than 40 thousand yuan per year on treatment in 54.7% families. One or both parents in 119 families were forced to stop working. 93.3% of them suffered emotion pressure and 56.7% lacked the knowledge about CP. 81% families thought that more social support should be offered in 6 aspects including government welfare, social security, medical institutions, psychotherapy, community services and legal aid. ConclusionAll society should pay more attention on the children with CP and provide a good rehabilitation environment for them.

Objective To systemically evaluate the therapeutic effect of pramipexole in treating Parkinson's disease. Methods Pubmed, Embase, Cochrane Database were used to search for randomized control trials (RCTs) on Parkinson's disease treated with pramipexole. Meticulous data wre extracted and meta-analysis was performed according to a preset protocol. Results Ten RCTs involving 1738 patients were included. The results of meta-analysis showed that pramipexole decreased the total scores of unified Parkinson's disease rating scale [UPDRS, WMD=-10.01,95%CI (-12.76,-7.26)],UPDRS part [WMD=-2.44,95%CI(-2.93,-1.95)],and UPDRS partⅢ[WMD=-6.61,95%CI(-8.38,-4.84)]. Pramipexole also reduced the score of UPDRS part Ⅳ[WMD=-0.73,95%CI(-1.16,-0.30)] in advanced patients(P＜0.05＝.Three studies referred to the effect of pramipexole in treating parkinsonian tremor. However there was a clinical heterogeneity among the studies, and two of them revealed a significant difference. Conclusions Pramipexole might improve motor symptoms and the quality of life in advanced patients, as well as improve tremor, which needs more RCTs to be confirmed.