Objective To explore the feasibility of two-port laparoscopic drainage in the treatment of liver abscess. Methods A total of 18 patients with bacterial hepatic abscess underwent twoport laparoscopic drainage.Two incisions were made at the superior border of the umbilicus and 4～5 cm below the right costal margin near the anterior axillary line,respectively.The abscess was cut through in "┼" or "╫" shape.The pus cavity was debrided bluntly,and a double-lumen drainage tube was placed.Results The laparoscopic drainage was performed successfully in all the 18 patients.The operative duration was 30～75 min(mean,45 min).A bile leakage for 80～100 ml per day occurred in 1 patient.The drainage tube was removed on the 12th postoperative day and the patient was discharged from hospital on the 14th postoperative day.Of the 18 patients,the hospital stay after operation was 7～14 d(mean,8.5 d).All the patients were followed for 5～12 months(mean,9 months) and no residual abscess or recurrence was found. Conclusions Two-port laparoscopic drainage for liver abscess is an ideal approach with advantages of simple manipulation,slight contamination inside abdominal cavity,little trauma,low complication rates,and rapid recovery.