Objective To assess the advese effects of SO2 on mortality of cardiovascular disease quantitatively. MeThod Based on bionomical theory,after the adjustment of time distribution,temperature,humidity and air pressure,the observed individuals were grouped into total population group,female group,male group,aged group,aged female group and aged male group.The association between SO2 and mortality rate of cardiovascular diseases was analyzed by Poisson regression and local auto-regression method.Ressults A 50?g/m3 increase of SO2 concentration caused 5.33% (95%CI=4.17%～6.49%)increase of mortality rate of cardiovascular disease in total people group,6.96% (95%CI=5.34%～8.60%)in female group,6.43%(95%CI=4.86%～8.03%)in male group,8 14%(95%CI=6 86%～9 46%)in aged group,6 40%(95CI=4 49%～8 34%)in aged female group,9 55%(95%CI=7 74%～11 39%)in aged male gruop.COnclusion SO2 could cause the increase of mortality rate of cardiovascular disease especially ofr aged people with cardiovascular disease.