Objective: To annually quantify the condylar growth from 7.5 to 15.5 years and identify the growth direction of condyle during the same period of time.Methods: The sample was obtained from Mathew's implant study with longitudinal cephalometric records of 13 untreated Class I subjects (8 Females, 5 Males). The cephalograms were taken annually from 7.5 to 15.5 years old. Reference lines were constructed based on three implants in mandibular corpus and linear and angular measurements performed. Results:It was found that the greatest amount of bone apposition at points of condylion and superior condylion occurred during the ages of 11.5 years to 12.5 years with the average value of (3.61?2.58) mm and (3.28?2.17) mm, respectively. The largest amount of bone addition at point of posterior condylion occurred much earlier between 8.5-9.5 years old, with average value of (1.92?1.16) mm. CRO angle was constantly decreased during the observation period. Conclusions:The current findings suggest that the condyle grows in forward and upward direction.

Histamine Antagonists ; administration & dosage ; therapeutic use ; Humans ; Phthalazines ; administration & dosage ; therapeutic use ; Rhinitis, Allergic, Perennial ; drug therapy

Aggressive T cell non-Hodgkin lymphomas are a group of highly malignant tumors characterized by rapid progress and short survival.This is especially true for patients who have a poor response to treatment because of their drug resistance.Hence,to clarify the mechanism of this resistance will have important guiding significance in reversing drug resistance and improving poor prognosis of aggressive T cell nonHodgkin's lymphomas.

Objective To observe the effect of rosuvastatin on the expression of vascular cell adhesion molecule-1 (VCAM-1) of renal tissue in patients with the early-stage diabetic nephropathy.Methods Sixty patients with early-stage diabetic nephropathy were divided into two groups by random digits table:rosuvastatin group and regular group.The patients were given 10 mg/d rosuvastatin besides the conventional treatment in rosuvastatin group.The levels of blood glucose,blood fat,renal function,high sensitivity C-reactive protein(hs-CRP),urine albumin excretion rate(UAER) and the expression of VCAM-1 were observed.Results Compared with those before treatment,the levels of total cholesterol (TC),low density lipoprotein cholesterol (LDL-C),trtglyeride (TG) showed no decrease after treatment [(5.83 ± 1.02),(3.48 ±0.60),(7.12 ±0.99) mmol/L] in regular group (P ＞0.05),but significantly decreased in rosuvastatin group [ (4.51 ± 0.95 ),( 3.18 ± 0.47),(7.02 ± 0.87 ) mmol/L ] (P ＜ 0.01 ).The levels of UAER and hs-CRP were significantly decreased in regular group and rosuvastatin group after treatment [ (78.3 ±31.7),(53.8 ± 24.9) μ g/min,and (2.15 ± 0.48),( 1.59 ± 0.55) mg/L] (P＜ 0.01 ),then rosuvastatin groupwas more conspicuous than regular group (P ＜ 0.05 ).The expression of VCAM-1 was less in rosuvastatin group than that in regular group.Conclusion Rosuvastatin can down-regulate the expression of VCAM-1 of kidney tissues in patients with the early-stage diabetic nephropathy and these indicate that rosuvastatin can reduce urine protein by inhibiting the inflammatory process.

Objective To discuss how to properly fuse Anesthesia Information Management System(AIMS)and original Clinical Information System in a hospital.Methods 3key problems in AIMS are discussed i.e.data acquisition,anesthesia fee and offline run.Results AIMS expanded and enhanced the system's utility and adaptability,which was helpful to other clinical information system as a reference.Conclusion Developed and expanded from the original system,AIMS in anesthesia department is fully utilized in daily medical treatment,teaching,scientific research and management.

Objective To study the effect of different concentrations of pravastatin treatment on macrophage polarity in mice .Methods The mice bone marrow sources of macrophages were cultured in vitro ,with the 0μmol/L sodium pravastatin group as control ,by giving 10 ,25 ,50μmol/L sodium pravastatin to conduct the drug intervention for 24 h .The enzyme linked immunosor-bent assay (ELISA) was used to detect the secretion of interleukin 10 (IL-10) and IL-12;the flow cytometry instrument was used to detect cell membrane CD16/32 ,CD206 expression;real time quantitative polymerase chain reaction (RT-qPCR) was adopted to detect toll-like receptor 4 (TLR4) ,myeloid differentiation factor 88 (MyD88) ,interferon regulatory factor 5 (IRF5) mRNA expres-sion .Results After the intervention of pravastatin sodium on macrophages ,as the pravastatin sodium concentration increase ,the expression of IL-12 and CD16/32 was decline ,while the expression of IL-10 and CD206 was risen ,which was accompanied by TLR4 ,MyD88 ,IRF5 mRNA expression down regulatyion ,and a dose dependent manner .Conclusion Sodium pravastatin promote the polarization of macrophages toward an anti-inflammatory macrophage phenotype (M2) ,this effect may be related with the anti-inflammatory effect of sodium pravastatin .

OBJECTIVE To investigate spectrum distribution of pathogens in patients with artificial airway and analyze their associated factors.METHODS The clinical data of 27 patients with tracheal intubation or tracheotomy from Mar 2005 to Mar 2006 were analyzed retrospectively.RESULTS Twenty seven patients were diagnosed as pneumonia.A total of 384 isolates of pathogens were collected from 258 sputum culture.The most were Gram-negative bacilli(293 isolates),and then were Gram-positive cocci and fungi.The four most pathogens were Pseudomonas aeruginosa,Stenotrophomonas maltophilia,meticillin-resistant Staphylococcus aureus(MRSA) and Acinetobacter baumannii.More multiple drug resistant(MDR) pathogens were detected in patients two weeks after intubation or tracheotomy than that after one week,and it was the same with sensitive rates to antibiotics of G-bacilli.CONCLUSIONS Patients with artificial airways have a higher morbidity of MDR pathogens and longer retention time of artificial airway can increase infection of MDR pathogens of lower respiratory tract.

Administration, Sublingual ; Humans ; Immunotherapy ; methods ; Inflammation ; Respiratory Hypersensitivity ; therapy

Objective To investigate the effect of intraperitoneal injection of compound sophora injection in the treatment of advanced gastric cancer patients with malignant peritoneal effusion.Methods 60 advanced gastric cancer patients with peritoneal fluid were randomly divided into two groups according to the different treatment meth-ods.A group of compound sophora injection with intraperitoneal therapy(group A),treatment 2 times per week for four weeks,Another group of compound sophora injection with vein therapy (group B),for 4 consecutive weeks.The efficacy of the two groups was compared.Results The effective rate of group A was 58.1%,which was higher than 27.6% of group B,the difference was statistically significant(χ2 =5.69,P <0.05).Conclusion Intraperitoneal perfusion with compound sophora injection can improve the effect in the treatment of peritoneal effusion in patients with advanced gastric cancer,and the adverse reaction is mild,it is worthy of clinical application.

Objective To evaluate the association between serum ferritin and the risk of cardiovascular disease among the Chinese population.Methods Based on the data from China Health and Nutrition Survey 2009, we used the Framingham risk score to calculate the 10-year risk of cardiovascular disease and analyzed the association between serum ferritin and the risk of cardiovascular disease in different gender by logistic regression analysis.Results Among 6 551 respondents, 3 035 (46.3%) were males and 3 516 ( 53.7%) were females whose mean age were ( 49.3 ±13.8 ) and ( 49.2 ±13.7 ) years, respectively.The median level of serum ferritin was 75.08 ( 36.71 -138.75 )μg/L.According to the 10-year risk of cardiovascular disease calculated by the Framingham risk score , the low risk group, middle risk group and high risk group were accounted for 79.5%( n=5 207 ) , 15.7% ( n=1 028 ) and 4.8%( n=316), respectively.The median of serum ferritin (121.61 vs.46.14, P<0.01) and the Framingham risk score (8.6 ±6.0 vs.7.3 ±1.6, P<0.01) of males were higher than those of females.The percentages of the middle risk group ( 30.6% vs.2.8%) and high risk group ( 9.8% vs.0.5%) of 10-year risk of cardiovascular disease in males were higher than those in females ( P <0.01 ).The 10-year risk of cardiovascular disease ≥10%increased with the increasing of serum ferritin in females ( trend P<0.01 ) but not in males.Conclusion Serum ferritin levels are positively correlated with the risk of cardiovascular disease in female Chinese.