The article makes a tentative practice to specialized English teaching for postgraduates from teaching content,pattern and evaluation system,and concludes some useful experience on how to enhance their Language ability under the background of international academic communication.

Community-acquired Pseudomonas aeruginosa bacteremia in children is uncommon but often fatal.Fever,diarrhea,dyspnea or tachypnea are the most common initial symptoms.Ecthyma gangreno-sum is the characteristic skin lesion of Pseudomonas aeruginosa bacteremia.Complicated with shock,respira-tory failure,multiple organs dysfunction and inappropriate initial antimicrobial therapy are the risk factors for mortality.The key to early diagnosis is to obtain blood culture as soon as possible and early recognition of the characteristic skin lesion.For suspected cases,it is advisable to cover for Pseudomonas aeruginosa sepsis with anti-Pseudomonas antibiotics.

Objective To understand the residual risk of transfusion blood donation in the native region and to conduct the sim-ple comparison of Roche diagnostic company′s first generation and second generation nucleic acid combined detection reagents . Methods The menstrual blood specimens qualified by the routine test in this center (serology test and enzyme immunodetection as-say results were negative) from May to July 2013 were selected and performed the 6-specimen mixed sample test by adopting the Roche Diagnostics company′s first-generation and second-generation nucleic acid combined detection reagents in the United Roche COBAS s 201 operating system ,if the test had the reactivity ,the nucleic acid identification tests and other complementary serologi-cal testing were performed .Results 9 417 specimens were detected ,8 cases of nucleic acid positive were screened out with the posi-tive rate of 0 .85 ‰ ,through the detection of nucleic acid identification reagents ,4 specimens were confirmed as positive for HBV nucleic acid ,1 case was positive for HCV nucleic acids and the rest 3 cases of uncertain HBV-positive .In addition ,with the first generation reagent (reference reagents) as the relative standard ,the second generation reagents (assessment reagent) had the over-all positive coincidence rate of 66 .67% ,the negative coincidence rate of 99 .98% and the total coincidence rate of 99 .96% .In addi-tion ,no HIV nucleic acid positive specimens was found by the nucleic acid test .Conclusion The nucleic acid detection technique can effectively shorten window period,further improve the safety of blood transfusions ,at the same time the overall conformance situ-ation of the Roche′s first-generation nucleic acid combined detection reagents and the second generation combined detection reagents is good ,but there are still lesser differences in the detection of HBV .

Before 2002, the three existing basic medical security systems of Thailand covered 30% of the population, and the surplus population participated in the universal coverage(UC)policy of medical security system which promulgated in 2002. Since the implement of UC policy, it has improved the equity of medical service application and health financing, reduced Catastrophic Health Payments and low-income groups have obtained more benefits. The incidence rate of Catastrophic Health Payments decreased and the spending burden of catastrophic health expenditure in low-income groups decreased from 6.11%(2000)to 4.65%(2002).

Purpose To investigate the expression of Lgr5 in cervical squamous cell carcinoma (CSCC) and its significance.Methods Lgr5 protein expression was evaluated by immunohistochemistry of EnVision two-step in 83 paraffin-embedded CSCC specimens,56 normal cervical tissues specimens and 32 cervical intraepithelial neoplasia (CIN) specimens.The expression of Lgr5 mRNA was evaluated by RT-PCR in 13 pairs of surgically removed CSCC and adjacent normal cervical tissues.The correlation between Lgr5 expression and clinicopathological features were statistically analyzed.Results The positive proportion of Lgr5 protein in CSCC tissues was significantly higher than those in adjacent normal cervix (P ＜ 0.01) and CIN (P ＜ 0.05).The expression of Lgr5 in CSCC tissues was associated with grade of tumors (P ＜ 0.01) and depth of invasion (P ＜ 0.05),but not associated with age,tumor size,clinical stage and lymph node metastasis (P ＞ 0.05).Kaplan-Meier analysis showed that the 5-year survival rate of patients with Lgr5 overexpression was significantly lower than that of patients with lower expression (P ＜ 0.01).Conclusion The expression of Lgr5 in CSCC tissues may associated with grade of tumors and depth of invasion and may be involved in initiation and development of CSCC,and it may be a new assistant marker for prognosis of CSCC.

To better understand the current status of medical students in clinical medical ethics,we design the relevant questionnaire,with 468 medical students conducting a questionnaire survey.Findings in general are more satisfactory.but there are great differences on certain issues.Educational Strategies:medical education curriculum should open more humanities courses and post-clinical teachers should pay close attention to ethics education for medical students.

Objective To investigate the mechanism of anti-aging effect of Yangyan Quban particles on the aging skin. Methods With the dose of D-galactose 1000 mg/(kg?d) by sc administration to the female mice for 42 days, the aging model was established. The mice received Yangyan Quban particles (6.68, 3.34, 1.67 g/kg) by ig administration at the same time of injecting D-galactose. Forty-two days later, the dorsal skin samples were collected to determine glutathione peroxidase (GSH-Px) activity and serum estradiol (E2) contents, and the influence on uterus, ovary, skin dry and wet weight and the amount of water intake were studied. Results Compared with the aged model mice, the GSH-Px activity and E2 contents in the mice treated with Yangyan Quban particles were increased remarkably, especially the medium is the best dose (P

Objective To explore the effects of enalapril on spatial learning and memory,and to identify synaptophysin expression in hippocampus of streptozotocin-diabetic rats.Methods Forty rats were randomly divided into control group,diabetic model group and the enalapril treatment group.Streptozotocin-diabetic rat model was developed.The diabetic rats were treated with enalapril for 12 weeks.Then,the learning and memory abilities of rats were tested with Morris water maze;mRNA and protein expression of synaptophysin in hippocampus was detected by RT-PCR and immunostaining.Results Compared with diabetic model group,the enalapril treatment group showed a significant decrease in the mean time of escape latencies(P

OBJECTIVE:To provide reference for rational use of antithyroid drugs (ATD) in the clinic. METHODS:Retro-spective analyzed 60 cases of adverse reaction caused by Methimazole and Propylthiouracil in terms of age,gender,incubation peri-od,organ or system involved and clinical manifestation,which were searched from 2004 May-2014 Dec. in First Affiliated Hospital of Soochow University. RESULTS:Among 60 ADR cases,male was more than female,and the ratio of male to female was 1∶2.75;average age was(39.7 ± 13.4)years old,and 83.3%ADR occurred between 20 and 59 years old;66.7%ADR occurred within 30 days. Most common clinical manifestations were drug-induced liver disease(66.7%,40/60)and neutropenia(25%,15/60). There was statistical significance in the proportion of drug-induced liver disease caused by methimazole and propylthiouracil in all ADR cases(P<0.05),there was no statistical significance in the proportion of agranulemia caused by these two drugs(P>0.05). CON-CLUSIONS:Before and after the treatment of antithyroid drugs,it’s necessary to check hepatic function and the number of neutro-phile granulocyte,and we should monitor and follow up it to ensure the safe use of drugs.

The new,rapid,accurate and convenient tests for tuberculosis diagnosis and drug resistance are urgently needed for effective tuberculosis control.In this review,two novel,inexpensive diagnosis methods of active TB were introduced.They can detect tuberculosis disease and drug resistances directly form sputum specimens and might have greater applicability in developing countries.Several concerns about the research and development of innovative diagnosis technology in our country also are described.