Objective To investigate the effect of solution-focused therapy on the care burden and negative emotions of the primary caregivers with elderly patients with hip fractures. Methods One hundred and sixty-eight elderly patients with hip fractures and caregivers were divided into intervention group and control group with 84 pairs by random digits table method, and the two groups were given continual nursing care. At the same time, the primary caregivers of intervention group accepted the solution-focused therapy. Caregiver Burden Inventory (CBI), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS) were used as the evaluation indexes. Results Before intervention, the score of CBI, SAS,SDS was (42.07 ± 4.24), (50.75 ± 11.21), (51.59 ± 13.18) points in control group and (42.10 ± 3.96), (50.48 ± 12.59), (52.96 ± 13.51) points in intervention group, and there was no significant differences between two groups (P>0.05). After intervention, the score of CBI, SAS, SDS was (40.49±3.17), (50.64±11.33), (50.14±10.25) points in control group and (28.95±2.87), (36.73±9.45), (41.60±8.23) points in intervention group, and there was significant differences between two groups (t=5.42, 8.73, 7.45, all P<0.05). Conclusions Solution-focused therapy can effectively reduce the care burden of the primary caregivers of elderly patients with hip fractures and alleviate their anxiety and depression.

Objective To investigate the effect of folic acid on plasma homocysteine(Hcy) levels and major cardiovascular events in elderly patients with H hypertension.Methods 200 elderly patients with H hypertension were randomly divided into the observation group and control group with 100 cases in each group according to the digital list methods,the control group was given health education and routine anti-hypertensive drug for treatment while the observation group was given folic acid on basis of the conventional treatment,the Hcy levels after 3 months of treatment and incidence of major cardiovascular events among 3 years of the two groups were compared.Results (1) The level of plasma Hcy in the observation group decreased significantly after treatment,with statistically significant difference when compared with before treatment (t =12.32,P ＜ 0.05),that in the control group had no obvious change after treatment than before treatment,there was statistically significant difference between the two groups after treatment(t =11.45,P ＞ 0.05);(2) The occurrence of cardiovascular events among 3 year after treatment of the observation group was 6 cases,the incidence rate was 6％,the control group occurred 15 cases,the incidence rate was 15％,the difference in the incidence of the two groups was statistically significant(x2 =8.24,P ＜ 0.05).Conclusion Folic acid intervention can reduce the plasma Hcy levels in elderly patients with H hypertension and control the occurrence of cardiovascular events.

Three kinds of biomedical materials of stomatology were introduced,including metal materials,polymers and non-metal bio composites.The literatures related to stomatology biomedical materials from 2008 to 2015 were collected in PubMed medical literature retrieval service system,and then statistical method was used to analyze the literature number,the numbers of literatures on different materials as well as the nations distribution.Composite,intelligent and functional materials were pointed out to be taking the place of metal materials,and thus might extend their clinical application in the future.

Objective To analyze the incidence rate and the perioperative risk factors associated with delirium after cardiac surgery.Methods We enrolled 622 patients between October 2014 and March 2015 in the department of cardiovascular surgery in Henan Provincial People's Hospital who were allocated to group PD and non-PD according to the Confusion Assessment Method(CAM) after the cardiac operation.Baseline demographics,perioperative data,and postoperative outcomes of these patients were recorded and analyzed via chi-square test and multivariate logistic regression analysis to determine the risk factors of postoperative delirium.Results Postoperative delirium was detected in 102 patients according to CAM criteria.The incidence was 16.4％.Multivariate logistic regression analysis revealed that age (OR =3.456;95％ CI:2.431-4.569),preoperative atrial fibrillation (OR =1.987;95％ CI:3.562-7.862),prolonged surgery duration (OR =1.246;95％ CI:3.164-5.982),postoperative pain (OR =5.356;95 ％ CI:1.386-9.374)were independently associated with postoperative delirium after cardiac surgery.Conclusions Delirium is a frequent complication,age,preoperative atrial fibrillation,prolonged surgery duration,postoperative pain are independent risk factors for delirium following cardiac surgery.Management according to potential risk factors may be associated with preferable therapeutic outcomes.

Objective To study the radiation injury of rat C6 glioma cell line by high resolution,1 H-nuclear magnetic resonance (1 H NMR) spectroscopy,and to preliminarily investigate its mechanism.Methods Metabolite concentrations in C6 cells were determined by 1 H NMR spectroscopy.Comet assay was used to evaluate DNA damage.Flow cytometry was used to determine the cell cycle and apoptosis rate.Colony-forming assay was used to measure the colony-forming rate and preliminarily investigate the mechanism of radiation injury.The resuhs were analyzed by one-way analysis of variance and Pearson correlation analysis.Results With the increase in radiation dose from 0 Gy to 1,5,10,and 15 Gy,DNA damage was enhanced in a dose-dependent manner (P=0.000-0.690);the percentage of cells in G1 phase increased (P =0.026-0.749);the apoptosis rate significantly increased (all P =0.000);the colony-forming rate significantly declined (P =0.000-0.004);the Lac/Cr ratio significantly decreased (P =0.000-0.015),which had a negative linear correlation with DNA damage parameters (tail length,r=-0.971;％DNA in the tail,r =-0.998;tail moment,r =-0.995) and apoptosis rate (r =0.978).Conclusions 1 H NMR spectroscopy reveals that the change in the Lac/Cr ratio is associated with injury and apoptosis of C6 cells after radiation.1 H NMR spectroscopy has the potential to predict radiation injury of glioma.

Objective To investigate and analyse the status and influential factors of palliative care knowledge of nursing undergraduates,then provide theoretical basis for palliative care education. Methods Using random sampling method, 400 nursing undergraduates were investigated by Palliative Care Quiz for Nursing (PCQN) and palliative care attitude questionnaire. Results 366 nursing undergraduates completed the survey whose scores were 8.363 ± 4.240, and 66.9%(244/366) of them had never heard of palliative care. Choosed right rate of PCQN was 41.13% (150/366). The scores of palliative care philosophy and principles 0.298±0.248, pain and symptom control and psychological scores 0.436 ± 0.235 and social and spiritual support scores 0.499 ± 0.318 had significant difference (F=38.866, P=0.000). The scores of palliative care attitude questionnaire were 36.756 ± 3.183, and the average score of all items were over 3. The palliative care attitude scores had significant difference in different grade (F=2.737, P=0.043). Conclusions Nursing undergraduates hold positive attitudes of palliative care, but the cognition degree were at a low level. To promote the development of palliative care, it should be strengthened publicity, education and training in this area. It is necessary to carry out palliative care education in nursing undergraduate students.

Objective To explore relationship of the anesthetic risks and intraoperative complications.Methods Preoperative anesthetic risks were assessed with Hussman's method from May 2015 to May 2016 in 2 494 surgical patients, including 1 462 males and 1 032 females.Intraoperative data and complications were tracked and recorded.Results Three hundred and thirty-six intraoperative complications occurred, accounting for 13.47% of total patients.The cardiovascular complications were a major intraoperative complications, accounting for 80.7%.2 494 patients were graded respectively into risk grade 1 with 1 540 (61.75%), grade 2 with 660 (26.46%), grade 3 with 202 (8.10%), grade 4 with 80 (3.21%) and grade 5 with 12 (0.48%).The incidence of complications were 112 (7.28%), 82 (12.42%), 82 (40.59%), 50 (62.50%) and 10 (83.33%) respectively.The sensitivity of prediction was 33.33%, 24.40%, 24.40%, 14.88% and 2.78%;the specificity 33.76%, 73.26%, 94.44%, 98.61% and 99.91%;and the accuracy 33.76%, 66.64%, 85.01%, 87.33% and 86.85%, respectively, in patients with risk grade 1, 2, 3, 4 and 5.Conclusion Hussman's method of anesthetic risks well predicts the intraoperative complications.

Objective To analyze the nutritional status of patients with continuous ambulatory peritoneal dialysis and explore reasonable and effective nursing measures.Methods Nutritional assessment was performed in 60 patients with continuous ambulatory peritoneal dialysis,using subjective integrated nutritional assessment,dietary analysis,measurement of biochemical indexes of the human body to analyze the factors that might affect the nutritional status of patients.Results 60 cases of malnutrition occurrd in 20 patients (33.3per cent),mainly due to insufficient protein and energy intake,inadequate dialysis,peritoneal inflammation,metabolic acidosis,psychosocial factors and not using erythropoietin,and so on.Conclusions Measures such as emphasis paid to malnutrition status of continuous ambulatory peritoneal dialysis patients,giving guidance of rational diet,performing full implementation of nursing measures according to the related factors,can improve the nutritional status of patients and improve patients' quality of life.

Objective To investigate the application value of solution focused brief therapy in the caring of patients with ulcerative colitis (UC). Methods A total of 180 active UC patients were assigned into control group (90 cases) and observation group (90 cases) using random number table. The two groups were given continuous nursing. For the observation group, the patients received the intervention of solution-focused brief therapy. SF-36 Health Survey (SF-36), Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS) and treatment efficacy rate before and after the interventions were compared between the two groups. Univariate analysis was used to determine the related factors of effective treatment of UC. Results Before the intervention, there was no significant difference in the eight scales of SF-36 between the two groups (P>0.05). After the intervention, the eight scales of SF-36, ie, physical functioning, role limitations due to physical health problems, bodily pain, vitality, general health, social functioning, role limitations due to emotional health problems, and mental health were (70.0±20.9), (72.2± 16.3), (71.9 ± 21.7), (68.7 ± 18.2), (70.4 ± 19.3), (69.5 ± 20.4), (68.9 ± 19.3), (72.6 ± 19.7) points in the observation group, and (62.2 ± 18.7), (66.3 ± 18.8), (65.7 ± 15.2), (62.6 ± 17.4), (62.9 ± 14.9), (63.5 ± 14.6), (61.9±15.2), (64.1±14.5) points in the control group, and there was significant difference between the two groups (t=2.220-3.291, P<0.01). Before the intervention, there was no significant difference in SAS and SDS between the two groups(P>0.05). After the intervention, SASand SDS was (37.3±10.8), (36.8±10.6) points in the observation group and (41.0 ± 11.6), (41.3 ± 12.7) points in the control group, and there was significant difference between the two groups (t=2.215, 2.581, P<0.05) . The efficacy rate was 88.9％(80/90) in the observation group, and 73.3％(66/90) in the control group, and there was significant difference between the two groups (χ2=7.420, P=0.024). Solution focused brief therapy was the related factor of effective treatment in UC patients (χ2=7.107, P=0.008). Conclusions Solution focused brief therapy could improve the quality of life, reduce anxiety and depression, and increase the treatment efficacy in patients with UC, which was an effective intervention method with clinical application value.

Objective? To establish a individualized predictive nomogram model for enteral nutrition feeding intolerance (ENFI) by analyzing the risk factors of ENFI in patients with severe acute pancreatitis (SAP). Methods? The clinical data of 188 SAP patients hospitalized in Shandong Provincial Hospital Affiliated to Shandong University from January 2015 to December 2017 were retrospectively collected by objective sampling. Univariate and multivariate Logistic regression analysis were used to identify the independent risk factors of ENFI. R software was used to establish a predictive nomogram model. Bootstrap method was used to validate the nomogram model and ROC curve was used to explore the predictive efficacy of the model in predicting the ENFI. Results? A total of 49 cases out of 118 SAP patients developed ENFI, with an incidence of 41.5%. The result of Logistic regression analysis showed that the independent risk factors of ENFI in SAP patients were age≥ 70 years old (OR=1.377, 95%CI: 1.088-1.743), fasting blood glucose≥ 11.0 mmol/L (OR=3.222, 95%CI:1.545-6.719), enteral nutrition starting time≥72 h (OR=3.800, 95%CI: 1.541-9.370), no dietary fiber added (OR=7.419, 95%CI: 2.651-20.760) and intra-abdominal pressure≥ 15 mmHg (OR=3.881, 95%CI: 1.735-8.679)(P＜ 0.05). The nomogram model showed that the consistency index for predicting the risk of ENFI in SAP patients was 0.869, while ROC curve showed that the area under the curve for the nomogram model predicting ENFI was 0.857 (95%CI: 0.779-0.931). Conclusions? The independent risk factors of ENFI in SAP patients are age≥70 years old, fasting blood glucose≥11.0 mmol/L, enteral nutrition starting time≥72 h, no dietary fiber added and intra-abdominal pressure ≥15 mmHg. The nomogram established in this study can predict the risk of ENFI in SAP patients with good discrimination and accuracy, which could be used for predicting individual ENFI in SAP patients.