Objective To explore the relationship between single nucleotide polymorphisms (rs12953-717) of SMAD7 and susceptibility of non-small cell lung cancer (NSCLC) in Chinese Han population.Methods A single nucleotide polymorphisms (rs12953717) from SMAD7 was detected via Sequenom system in 528 NSCLC cases and 762 healthy controls.Data was statistically analyzed by unconditional Logistic regression method.Results rs12953717 had significant differences between non-small cell lung cancer patients and the controls.Compared with CC/TT (CC combined with TT) genotype,the adjusted odds ratio for the CT genotype was 4.107 (95％ CI:3.206 ～ 5.260,P =0.000 1).Smokers had a 2.004 odds ratio (95 ％ CI =1.583 ～ 2.537,P =0.000 1) of NSCLC compared with the controls.There was a 10.074-fold increased risk of NSCLC among the subjects with CT genotype and smokers.Conclusion The polymorphism of rs12953717 may have relation with risk of NSCLC.Heterozygote (CT) is a susceptibility genotype of NSCLC.Smoking is one of the risk factors of NSCLC.Smoking and CT genotype have synergistic effects on NSCLC susceptibility.

Objective To explore the differential diagnostic value of color-Doppler technique in acute and chronic thrombosis of leg arteries. Methods The two-dimensional and color Doppler ultrasonographic characteristics were analyzed in acute thrombostic event in 80 leg arteries and chronic thrombostic events in 244 leg arteries. And some parameters (history, the vessel wall structures, hemodynamic of inlet and outlet at the lesion) were compared, too. Results There existed a significant difference in history, vessel wall structure and the establishment of collaterals between the acute and chronic groups. And there were also significant difference in maximum blood velocity proximal and distal to the lesion and proximal resistant index between two groups(P