Objective To investigate the inflammation levels of 2-diabetes patients before and after 3 months of improving glycemic control.Methods A longitudinal study was performed in a subgroup of 48 subjects with T2D and poor glycemic control.Forty-four healthy individuals were taken as control group.The serum concentration of C-reactionprotein (CRP),interleukin-6 (IL-6),interleukin-6 (IL-8),transforming growth factor-β1 (TGF-β1) and transforming growth factor-β1 (MCP1) in all participants were measured simultaneously by multiplexed Luminex assay.Results The serum levels of CRP,MCP-1 of 2-diabetes patients were 3.96 (3.45,5.58) mg/L and (195.0± 129.8) ng/L,significant higher than those in control group (2.25 (1.24,3.22) mg/L,(148.5±85.7) ng/L),and the differences were significant(t=-2.580,P=0.010;t=-2.118,P =0.047).No significant difference was found in the serum levels of IL-6,IL-8,TGF-β lbetween the two groups (P＞0.05).TGF-β1 level in patients with good glycemic control decreased to 26.85 (23.17-31.12) ng/l,significant lower than that before glycemic control (43.5(26.5-62.25) g/L;Z=-2.191,P=0.028),and there were no significant differences among the other 4 kinds of inflammatory factors before and after blood glucose control(CRP:Z =-0.937P =0.372;IL-6:Z =-0.875,P =0.396;IL-8:Z =-1.215,P =0.286;MCP-1:t =-1.846,P=0.065).Conclusion Low grade systemic inflammation status in T2D patients.Improvement of glycemic control reduces TGF-β1 levels and plays a key role in delaying the development of diabetic nephropathy.

Objective To explore the value of high-resolution MRI in in the preoperative evaluation of children with type Ⅰ focal cortical dysplasia (FCD). Methods The MRI and related clinical data of 52 children with FCD Ⅰ confirmed by pathology were retrospectively analyzed,Compare the detection rates of major MRI signs of type Ⅰ FCD (focal demarcation of gray and white matter,focal cortical structure abnormalities,abnormal white matter signal lesions,and local atrophy / hypoplasia) of high-resolution imaging and conventional MRI sequences,and comparisons in the assessment of lesion extent,borders,and completeness were perfomed. Results The detection rate of high-resolution imaging for blurring of gray-white matter boundaries,focal cortical structural abnormalities,and abnormal white matter abnormalities was higher than that of conventional sequences (P<0.05),there was no significant difference in the detection rate of local atrophy/dysplasia (P>0.05). 3D-T1WI showed the range and boundary of the lesion better than the conventional T1WI sequence,3D-T2FLAIR was more complete than the conventional T2FLAIR sequence. Conclusion The high-resolution MRI could improve the detection rate of various major signs of type Ⅰ FCD,could more fully display the lesion and accurately assess the scope and boundary of the lesion,and was the preferred MRI imaging sequence before surgery.