With the frequent occurrence of natural disasters, incidence rate of PTSD and sleep-disorder is rising. So, how to treat them effectively has become a hot spot. This article analyzed the literature about improvement of PTSD and sleep-disorder based on the perspective of soothing and regulating liver, and primarily discussed the effectiveness and feasibility of treating PTSD from liver, with a purpose to lay work foundation for improving common diagnosis and treatment system of PTSD and sleep-disorder.

Objective To determine the content of ferulic acid, water and extract of Angelica formula particles, provide a reliable method for evaluation and quality control, and compare the quality of Angelica formula particles and Angelica pieces. Methods HPLC method was used with Kromasil C18 column (4.6 mm×250 mm, 5μm), flow rate of 1.0 mL/min, detection wavelength of 316 nm, column temperature at 28 ℃. The mobile phase was acetonitrile-0.05%phosphoric acid in water gradient elution system. Results Ferulic acid showed good linear relationship in the range of 0.033-0.165 μg (r=0.999 8). The average recovery was 98.78% and RSD=0.99%. Angelica formula particles met the quality requirement in the content indicators, the content of ferulic acid was higher than Angelica pieces. Conclusion The HPLC method for determination of ferulic acid in Angelica formula particles is simple and reliable, with good reproducibility, and can be used as the quality control method of Angelica formula particles.