An observation of nerve terminals in the induced glioblastoma of mouse was made by Nonidez and Glees impregnation method.In the marginal zones of the glioblastoma innoculated in the brain or muscle,nerve fascicles of various sizes with or without the blood vessels could be seen. In some case the nerve fibers formed a perivascular plexus through the perivascular space and some nerve fibers terminated on vascular walls.The nerve fibers within the tumor seemed to be related to those nerve fibers distributed in the brain tissue near the tumor or in the subcutaneous tissues, hair follicules of muscles around the tumor, hence, we suggest that the nerves whthin the tumor were growing in from the surrounding normal tissues.The amount of the nerve fibers was more abundant in the periphery than in the center of the tumor, the nerve fibers ran through the stroma or parenchyma of the tumor and gave out many branches to the tumor cells, we have also observed various types of nerve terminals for example: bulbar, isolated bifurcated, fusiform,circular, branched, brush-formed and club-formed endings.According to the findings mentioned above, it is concluded that the induced glioblastoma of mouse is innervated by nerve endings.

OBJECTIVETo explore the influence of Chinese medicine constitution type on the susceptibility of hypertensive patients to intracerebral haemorrhage.

METHODSPrimary hypertensive patients were studied and divided into the hypertension and the hypertensive intracerebral haemorrhage groups, depending on whether or not the patients had intracerebral haemorrhage. The demographic characteristics, physiological characteristics, living habits, biochemical tests, other chronic diseases, Chinese medicine constitution type, etc. were collected and compared between the two groups. The neurological deficit in the hypertensive intracerebral haemorrhage group was also compared among the different constitution types.

RESULTSA total of 304 patients participated in this investigation, including 213 cases in the hypertension group and 91 cases in the hypertensive intracerebral haemorrhage group. The percentages of dampness-heat and qi-depression types in the intracerebral haemorrhage group were greater than those with the same types in the hypertension group (20.9% vs 6.1%, 22.0% vs 8.0%; P<0.05). The percentages of each constitution type were different between genders in both groups. In addition, there were more male cases (14/20) with qi-depression type and more female cases (7/8) with phlegm-dampness type in the hypertensive intracerebral haemorrhage group than those with the same types (3/17 and 9/34, respectively) in the hypertension group (P<0.05). The cases with phlegm-dampness and qi-depression types had greater levels of blood lipids in the intracerebral haemorrhage group than those with the same types in the hypertension group (P<0.05). Furthermore, the cases with the qi-deficiency type presented with a more severe neurological deficit than those with the other types (P<0.05).

CONCLUSIONSChinese medicine constitution type might have an impact on the susceptibility of hypertensive patients to have an intracerebral haemorrhage. The heat-dampness and qi-depression types might lead to greater susceptibility than the other types. In addition, the patient's gender and blood lipids might also influence the susceptibility along with the constitution type.

Aged ; Body Constitution ; Cerebral Hemorrhage ; etiology ; Disease Susceptibility ; pathology ; Female ; Humans ; Hypertension ; complications ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Nervous System ; pathology

ObjectiveTo test the effect of human tremor detector in clinic based on the principle of photoelectrical transformation.MethodsFifty-five subjects including normal youth and elderly persons, patients with Parkinson's disease (PD), hyperthyroidism and cerebellor ataxia were tested with human tremor detector. The displacement, frequency spectrograph, velocity and acceleration of both hands in four kinds of postures and action were involved.ResultsThe physiological tremor and pathological tremor in different kinds of patients were significantly different (P<0.05). Especially in PD, both quantitive and qualitative data had a significant difference.ConclusionHuman tremor detector can provide the evidence for early diagnosis of PD.