Objective To assess the relationship between fractional esterification rate of high density lipoprotein cholesterol (FERHDL) and coronary artery disease .Methods The patients were underwent coronary angiography in this hospital in the last three years were collected ,according to the results of coronary angiography ,286 patients were divided into CHD group(n=196) and non-CHD group(control group ,n=90) .And according to the number of pathological coronary artery ,the patients with coronary heart disease were divided into single-vessel subgroup(n=73) ,double vessel lesion subgroup(n=72) ,three branch lesions subgroup (n=51) .The relationship between FERHDL and coronary artery disease were analyzed .Results The FERHDL of CHD group was significantly higher than that in the control group ,the difference was statistically significant (P<0 .05) .It was a tendency that the FERHDL increased with coronary lesions increasing (P<0 .05) .The FERHDL was significant independent correlated with the low density lipoprotein cholesterol b-C(LDLb-C) ,triglycerides(TG) ,high density lipoprotein cholesterol 2-C(HDL2-C) ,high density lipoprotein cholesterol C(HDL-C) .FERHDL was positively correlated with LDLb-C(r=8 .473 ,P=0 .000) ,TG(r=0 .714 ,P=0 .002) and negatively correlated with HDL2-C(r= -0 .692 ,P=0 .024)、HDL-C(r= -0 .829 ,P=0 .008) .Conclusion The value of FERHDL was significantly increased in CHD patients and correlated with the aggravation severity of the CHD .The change of FERHDL was significant correlated with particle size of HDL and LDL particle size .

AIM: To observe the effect of curcumin on the proliferation and apoptosis of prostate cancer cell line LNCap.METHODS: LNCap cells were treated with different doses(10 ?mol/L,20 ?mol/L,30 ?mol/L,40 ?mol/L) of curcumin and its effects were analyzed in cell growth and apoptosis by microscope,MTT colorimetric assay and flow cytometry.The expression of prostate specific antigen(PSA) was measured by AXSYM~(TM) system-chemical luciferase methods and expression of androgen receptor (AR) was detected by Western blotting.RESULTS: The results showed that curcumin inhibited the proliferation of LNCap cells.The cell growth was inhibited by curcumin in a dose dependent manner and the optimal dose and time was 40 ?mol/L,24 h.Curcumin induced apoptosis in LNCap cells,the most dramatic dose was 40(?mol/L) curcumin,at this dose the apoptosis rate was 9.23%. Curcumin inhibited the expression of PSA in LNCap cells and the most dramatic dose and time was 40 ?mol/L,24 h.The PSA in this group was 20% of the control group.Curcumin inhibited the expression of AR on prostate cancer cells.CONCLUSION: Curcumin decreases proliferation and induces apoptosis in LNCap cells in a dose-dependent manner.Curcumin also inhibites the expression of PSA and AR on LNCap cells.

AIM: To study the effect of curcumin on the expression of p21 and CD44V6 in breast carcinoma in nude mice.METHODS: Nude mice were xenografted with human breast cancer cell line MCF-7 and randomly divided into 2 groups(n=4 in each group): control group and curcumin group.In latent period,the percentage of tumor development was observed.Tumors were measured and the surface areas were calculated.RT-PCR was performed to detect the expression level of cyclin D1,p21 and CD44V6 mRNA.RESULTS: The tumor surface areas in the curcumin group were significantly lower than those in control group.In curcumin treatment group,the expression of p21 was up-regulated while cyclin D1 was nearly not changed.The expression of CD44V6 was significantly down-regulated in curcumin group.CONCLUSION: Curcumin inhibits the expression of CD44V6 and up-regulates the expression of p21 in nude mice bearing human breast cancer cell line MCF-7.