Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Combined Modality Therapy ; Humans ; Neoplasms ; drug therapy ; radiotherapy ; surgery ; Particle Accelerators ; Radiation Dosage ; Radiotherapy, High-Energy ; methods ; Salvage Therapy

Objective To investigate the expression of thymosin beta4 ( Tβ4 ) in the liver tissues of children with hepatoblastoma ( HB) , and further study the function of Tβ4 in HB metastasis in vitro. Methods Immunohisto-chemistry (IHC) was used to determine expression of Tβ4, E-cadherin andβ-catenin in liver tissues from 19 chil-dren with HB,and further to analyze its function in metastasis of HB cells. Results The positive rate of Tβ4 ( P<0.01 ) in HB liver tissues was significantly higher than it in the adjacent tissues. The positive rates of Tβ4 and nu-clearβ-catenin in HB with lymphnode metastasis were significantly higher than in HB without lymphnode metastasis ( P <0.01 ) . While expression of E-cadherin in HB with lymphnode metastasis was lower than in HB without lymphnode metastasis ( P<0.01 ) . Scratch-wound assay showed that HepG2 cells with Tβ4 knockdown had signifi-cantly lower metastatic ability (P<0.05). Conclusion Tβ4 plays an important role in HB metastasis, suggesting it is a potential target for HB metastasis.

Objective To provide basis for rational drug use of clinical practice by analysis of antidepressants application in Wuhan. Methods Antidepressants were classified according to the structure and mechanism. By using the analytical method of the defined daily dose (DDD) recommended by WHO,authors statistically analyzed the relative data of antidepressants used in 34 hospitals of Wuhan from 2011 to 2013. Results The consumption of the antidepressants had been increased year by year,selective serotonin reuptake inhibitor (SSRIs) and serotonin noradrenergic reuptake inhibitors (SNaRIs) were widely used and presented higher proportion than others in the consumption of antidepressants,the average amount of the sales was 50.49% and 21.81%,respectively.The application of tricyclic antidepressant (TCAs) decreased in Wuhan,the amount of sales for 3 years accounted for 0.56%,0.37% and 0.15%. Conclusion SSRIs and SNaRIs have already become the first-choice drugs in clinic practice because of good efficacy and high safety,other new types of antidepressants have a great potential for development,TCAs are fewly used now.

Objective:To review the new progress in hydrogen peroxide disinfection and sterilization technology and equipments. Methods:Based on the recently published papers and our research results,the hydrogen peroxide sterilization technology and equip-ments were classified and summarized. Results:The hydrogen peroxide nano-fog( ultra-dry fog) sterilization technology and equipments could be used for the sterilization of space and equipments with the properties of safety, effectiveness and compatibility. Conclusion:The nano-fog( ultra-dry fog) sterilization technology and equipments exhibit broad application prospects,which is an ideal method to re-place the conventional space sterilization using formaldehyde and ozone.

Objective To establish a method of HPLC for determination of salidroside in Jintianquban Tablets. Methods Waters C18 column was used. The methanol-water was used as the mobile phase. The flow rate was 0.8 mL/min. The detection wavelength was set at 276 nm. Results For salidroside, the linear range was 0.3 456~3.456 ?g, and the average recovery rate was 100.3% with RSD=1.71%. Conclusion The method is simple, reliable, accurate and can be applied to the quality control of the preparation.

Effective management for hypertension in renal diseases should be carried out according to the principles of 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension.The important role of kidney in the classification of hypertension,the corresponding therapy,the set of the target blood pressure,the choice of antihypertensive agents and combination therapy should be focused.Comprehensive approaches should be used for the treatment of hypertension in renal diseases to protect the target organs(including the kidney).Appropriate prevention and management strategies for hypertension in renal diseases should be disseminated and optimized.

Objective To investigate the incidence and risk factors of concomitant atherosclerotic renal artery stenosis(ARAS)and coronary heart disease(CAD).Methods In the study period 247 patients with known or suspected CAD underwent combined cardiac catheterization and renal artery angiography.Results Incidence of ARAS was 20%(44/220)in CAD.Logistic regression analysis showed only age,degree of coronery artery stenosis,peripheral atherosclerosis disease were independently predictor of ARAS.Conclusions Renal artery angiography should be performed routinely to indentify ARAS,especially in the patients with mutil-vessel lesions,old age and peripheral atherosclerosis disease.

OBJECTIVE:To prepare rufloxacin hydrochloride gel and establish a quality control method of the gel METHODS:Carbopol940 was used as the gel base,the content of rufloxacin hydrochloride was determined with UV-spectrophotometry and the stability test was performed RESULTS:There was a good linearity of calibration curve of rufloxacin hydrochloride in range 2～10?g/ml,r=0 9 999,the average recovery was 99 53%,RSD was 0 38%(n=6) The gel was stable CONCLUSION:The design of the gel formulation is reasonable The gel can be prepared feasibly and is stable in quality,convenient in use

0.05). Platelet decreased significantly in group A (P

Intestinal parasitic infection is a serious public health problem in the world especially in the developing countries,and it is also the important part that impacts human health,especially in children in the rural areas of China.Factors such as water,environmental sanitation,health behavior and so on are related with intestinal parasitic infection.The research progress of the prevalence of intestinal parasitic infection in the world and the factors that affect the health of people,especially in children in the rural areas were reviewed in the present paper.