Breast Neoplasms ; blood supply ; classification ; genetics ; pathology ; Female ; Genes, BRCA1 ; Genes, MDR ; Genes, erbB-2 ; Humans ; Lymphatic Metastasis ; Mutation ; Neovascularization, Pathologic ; Sentinel Lymph Node Biopsy

Breast Neoplasms ; diagnosis ; pathology ; Carcinoma ; diagnosis ; pathology ; Female ; Humans ; Male ; Mammography ; methods ; trends ; Neoplasm Invasiveness ; pathology ; Neoplasm Proteins ; analysis

Breast Neoplasms ; chemistry ; diagnosis ; pathology ; Carcinoma, Ductal, Breast ; chemistry ; diagnosis ; pathology ; Carcinoma, Papillary ; chemistry ; diagnosis ; pathology ; Diagnosis, Differential ; Female ; Humans ; Lymphatic Metastasis ; Neoplasm Invasiveness ; Prognosis ; Receptor, ErbB-2 ; analysis ; Receptors, Estrogen ; analysis

Angioimmunoblastic T-cell lymphoma(AITL) is a subtype of peripheral T-cell lymphoma,clinically characterized with systemic symptoms and aggressive behaviours. To date, the standard approach for treating patients with AITL is still unknown. Combination chemotherapy regimens have failed to significantly improve prognosis and durably maintain the remission. Targeted drugs and immunomodulator agents could not conclude the role because of the small number of patients in these studies. High dose therapy with autologous stem cell transplantation and allogeneic hematologic stem cell transplantation are both comparatively efficient.High dose therapy with autologous stem cell transplantation has many risks, such as higher relapse rate and long-term secondary tumor. Owing to higher transplant related mortality , allogeneic hematologic stem cell transplantation will be further explored. This review presents the status of treatment study in AITL.

Objective To analyze the clinical nusing care methods and effects of patients complicated with tuberculosis during pregnancy or puerperal state.Methods Clinical data of 39 cases of patients complicated with tuberculosis during pregnancy or puerperal state were retrospective analyzed.Results After comprehensive treatment and nursing care,4 cases died,others got good prognosis.Conclusions Meticulous treatment and nursing can promote the rehabilitation of patients complicated with tuberculosis during pregnancy or puerperal state.For these patients,the cure rate can be improved and the recurrence rate can be reduced by choosing suitable treatment and nursing care programs,paying attention to psychological care and health education,ensuring patients taking medicine regularly.

Breast Neoplasms ; pathology ; surgery ; Carcinoma, Ductal, Breast ; pathology ; surgery ; Carcinoma, Papillary ; pathology ; surgery ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Mastectomy, Segmental ; Neoplasm Invasiveness

Metabolic bone disease(MBD) in preterm infant is a disorder of calcium and phosphorus metabolism that leads to a decrease in bone mineral content, resulting in clinical, biochemical, and imaging changes.It occurs mostly in very low birth weight and extremely low birth weight newborns.The clinical symptoms usually occur from 6 to 12 weeks after birth, mainly manifested as dyspnea accompanied by mechanical ventilation for a long time, rickety-like changes, and even fracture in severe cases.At present, diagnosis of MBD is characterized by biochemical markers, radiology and ultrasound.As the clinical manifestations of MBD in prematurity occur late, early screening and prevention for high-risk groups play an important role to reduce the risk of MBD.

Biomedical Research ; Heart Rate ; Humans ; Pneumoconiosis ; physiopathology

Objective To explore the relationship between the protein expression of PCNA and biological behavior science in benignant pituita ry adenoma.Methods The protein expression of PCNA in 58 patien ts with pituitary adenoma were determined by ABC immunohistochemical method.Results The PCNA index was significantly higher in the patients with recurrent pituitary adenomas than in nonrecurrent ones(P<0.05).There was no significantly difference between bleeding and unbleeding group,cystic and noncystic group,large type and unlarge type group(P>0.05 respectively) .Conclusion The protein expressions of PCNA reflected the proli ferative activties of pituitary adenomas, and could be taken as one of the indic ators to evaluate recurrence and prognosis of the tumor.

A novel strategy employing dendrimer to multi-label the template molecule to improve the sensitivity of molecularly imprinted electrochemical sensor was proposed. The determination relies on a competition reaction between poly ( diethylene-triaminepenta-acetic acid )-glycol ester ( PDTPA )-ferrocene-carboxylic acid ( FcA ) labeled gibberellins acid 3 ( GA3 ) and GA3 in the sample. Since one cavity corresponds with multiple FcA, instead of only one FcA, the intensity of the detecting signal was greatly enhanced, so was the sensitivity of the sensor. Experimental results showed that the molecularly imprinted electrochemical sensor was sensitive to GA3 detection at a concentration from 2. 0í10-9 to 1. 0í10-7 mol/L, with a detection limit of 9. 3í10-10 mol/L. In addition, the sensor had good reproducibility and its feasibility was verified in the analysis of series of real beer samples.