1.Associations of MRI-lesions and clinical features with disability in Chinese patients with multiple sclerosis
Xiao-Juan Cheng ; Cheng ; Lin Miao ; Zheng-Liang Guo ; Yang-Tai Guan ; Zhen-Guo Liu ; Xin Wang ; Xiao-Jiang Sun ; Zhong-Xin Zhao ; Yong-Jian Song ; Xiao-Yi Ding ; Sheng-Di Chen ; Guo-Xin Jiang ; Fredrikson M
Neurology Asia 2013;18(4):391-399
Objective: To analyze associations of MRI-lesions and clinical features with disability in patients
with multiple sclerosis (MS) in Shanghai, China. Methods: We studied patients with MS, identified
from a survey in Shanghai, whose sites of lesions in the CNS was based on the MRI examinations.
Associations between MRI-lesions, various clinical variables and the severity of disability were analyzed
with univariate and multivariate logistic regression analysis. Results: There were 210 patients in this
study. The disability of the patients with lesions confined to the spinal cord was significantly more
severe than those with lesions in the brain (p < 0.008). Current age (OR: 1.041, 95% CI: 1.007~1.077),
MS duration (OR: 1.082, 95% CI: 1.011~1.159) and MRI-lesions in the spinal cord (OR: 2.441, 95%
CI: 1.039~5.737) were significantly associated with severity of disability on multivariate logistic
regression analysis.
Conclusion: MRI-lesions in the spinal cord, older age, a longer MS duration were significantly
associated with a more severe disability in this MS study in Shanghai China.
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