1.Successful management with artificial reproductive technology and preimplantation genetic diagnosis of a patient with alpha-thalassemia trait and repeated Hemoglobin Bart's Hydrops Fetalis Syndrome
Onari-Abdurahman Joycelyn ; Fernandez Ma.Asuncion
Philippine Journal of Reproductive Endocrinology and Infertility 2008;5():55-66
A 38 year-old woman who had history of repeated Hemoglobin Bart's Hydrops Fetalis Syndrome in her first two consecutive pregnancies, was diagnosed as having alpha-thalassemia trait. On further investigation was likewise found to have a-thalassemia trait. Successful term pregnancy wa achieved through in-vitro fertilization with preimplantation diagnosis. Alpha-thelassemia is a common genetic disease that is prevalent in Southeast Asia. A couple with a-thalassemia trait is asymptomatic, but, they have 25 percent chance of having a child with the most fatal type of thalassemia-Hemoglobin Bart's Hydrops Fetalis Syndrome. Preimplantation genetic diagnosis is an established technique that provides an alternative to prenatal diagnosis for patients who are at risk of transmitting serious genetic disorder to their offspring.
Human
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Female
;
Adult
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ALPHA-THALASSEMIA
2.Risk factors associated with malignant endometrial lesions in postmenopausal women presenting with abnormal uterine bleeding: a retrospective review
Uy Irene L. ; Fernandez Ma.Asuncion ; Bautista-Zamora Brenda Bernadette P.
Philippine Journal of Reproductive Endocrinology and Infertility 2010;7():1-6
Objectives: To identify clinical, sonographic and hysteroscopic characteristics associated with malignant endometrial lesions.
Methods: This is a retrospective descriptive study that included all menopausal women presenting with vaginal bleeding in a tertiary care hospital from January 2007 to June 2010. Clinical, sonographic and hysteroscopic findings were evaluated as predictor variables for development of endometrial adenocarcinoma.
Results: Thirteen out of the 215 patients had endometrioid adenocarcinoma, in women presenting with postmenopausal bleeding, with a prevalence rate of 6%. A trend towards harm is seen among the following factors: age of > 60 years (OR 1.19; 95% CI, 0.29-4.46), menarche < 12 years (OR 1.07; 95% CI, 0.22-4.66), endometrial stripe >/- 10mm (OR 2.02; 95% CI, 0.58-7.09), lesion of diameter < 1cm (OR 1.57; 95% CI, 0.45-5.74), presence of cystic space (OR 4.28; 95% CI, 1.00-17.36), and soft consistency (OR 1.94; 95% CI, 0.47-9.21).
Conclusion: Increasing age, early onset of menarche, endometrial thickness of >/- 10mm, hysteroscopic characteristics (lesion diameter of less than 1 em, presence of cystic space and soft consistency) increases the probability of carcinoma.
Human
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Female
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Aged
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Middle Aged
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ENDOMETRIAL NEOPLASMS
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HYSTEROSCOPY
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MENORRHAGIA
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UTERINE HEMORRHAGE