Introduction: HIV infection attacks the immune system, thus making a person vulnerable to various secondary diseases. Various secondary infections trigger systemic endothelium activation and lead to sepsis. Comorbid diseases
cause high morbidity and mortality rates in HIV patients. This study aims to determine the prevalence of secondary diseases in HIV patients. Methods: Analytic and descriptive study with crossectional study design. Data were
obtained from medical records of hospitalized patients at RSUD Dr. Soetomo Surabaya from August 2019 - February 2020. Results: Patients are dominated by the 30-39-year-old age group (48.8%) with male gender (69.4%),
high school graduates (69.4%), private employees (44.7%), Muslim (90.3%), married (53.1%), CD4 <100 cells/µL
(28.1%). From 392 patients, there were 46 2-time inpatients, seven 3-time inpatients times, and four 4-time inpatients, which brings a total of 320 HIV patients during the inclusion period. The highest prevalence of secondary
disease was candidiasis oris (56.3%), tuberculosis (40.9%), and anemia (39.7%). There was association between age
to complications (p= 0.042) and CD4 counts to complications (p= 0.022). Conclusion: HIV patients with CD4 counts
of less than 200 cells / µL are very susceptible to various secondary diseases.