Objective To investigate nursing methods of CT -guided 125I seeds implantation brachytherapy for malignant tumor. Methods Nursing methods in 236 cases of 125I seed implantation therapy were summarized. Results Perfect preoperative examination,and psychological intervention could significantly improve patients mental state. Observation distribution of particles and postoperative observation could promote patients postoperative recovery. Conclusion Preopertive and postopertive nursing and radiation protection is an important factor for 125I implantation brachytherapy