OBJECTIVE To learn the classification of candidal hospital infection and its antifungal drug susceptibility test,in search for prevention and treatment measure.METHODS The CHROMagar candida color medium was applied to isolate Candida,DADE WalkAway-40 and RY-ID were applied to identify Candida strains.Rosco disc diffusion method was applied to analyze susceptibility test of Candida strains.RESULTS Of the 702 isolates,70.0% were C.albicans,20.8% were C.glabrata,and 6.3% were C.tropicalis.The candidas showed various resistance to 6 anti-fungal drugs.CONCLUSIONS C.albicans is still the most common pathogen of candidal infection,but in other candida the percentage of C.glabrata is rising now.Amphotericin B,fluconazole,itraconazole and nystatin(Anticandine) have a good antifungal to all candidas,but flucytosine and ketoconazole have less susceptibility to them.So medication should be accorded with the results of antifungal susceptibility test.

Objective To detect the change of exoression level of plasma microRNA‐21(miR‐21) and TGF‐β1 in cardiac remode‐lin affer acute myocardial infarction(AMI) of the pateins .Methods 200 pateints with AMI and 100 normal controls(age ,sex matched) were enrolled .Blood samples were obtained from the normal controls and patients with AMI on the 3 days ,7 days and 14 days .Real‐time PCR was developed to detect the expression of miR‐21 and TGF‐β1 in plasma .Results The expression of miR‐21 was significantly up‐regulation in the 3 days ,7 days and 14 days in MI group than that cntrol group ,0 .74 ± 0 .21 vs .2 .62 ± 0 .23 , vs .3 .67 ± 0 .25 ,vs .4 .13 ± 0 .27 up‐regulation in the 3 days ,7 days and 14 days in MI group than that cntrol group ,0 .98 ± 0 .18 vs .2 .35 ± 0 .24 ,vs .3 .67 ± 0 .25 ,vs .4 .13 ± 0 .27 ,P<0 .05 ,respectively .The expression of miR‐21 and TGF‐β1 were up‐regulation with the change of cardiac function .Positive relationship between miRNA‐21 expression and LVDd (r=0 .757 ,P<0 .05);Positive relationship between TGF‐β1 mRNA expression and LVDd(r=0 .701 ,P<0 .05) .Conclusion The expression of miR‐21 and TGF‐β1 were up‐regulation in cardiac remodelin affer AMI of the pateins ,which involved in regulation in cardiac remodelin affer AMI .