CT colonography (CTC) has been widely used in diagnosis of colon diseases. Computer-aided detection (CAD) automatically detects the locations of suspicious lesions on CTC, and provides radiologists with a second opinion. CAD has the potential to increase radiologists' diagnostic performance in the detection of lesions and to decrease variability of the diagnostic accuracy among readers. The current fundamental scheme, the key techniques used for detection of lesions on CTC, the detection performance, as well as the pitfalls, challenges, and the future of CAD were reviewed in this article.

Objective To explore the baggy eyelids anaplasty through posterior orbital septum fat displacement. Methods Orbital septum and posterior orbital septum fat were exposed through palpebral margin incision, internal orbital septum fat was released and sutured with arcuate expansion of capsulopalpebral fascia at the middle lower eyelid, which was taken as the function of tighting the flaccid lower eyelid at transverse direction. On such a basis, the muscle and skin were repaired and so did orbital septum and baggy eyelids.Results Ofthe 38 patients with this operation, baggy eyelids anaplasty was performed with satisfactory results.Conclusion The method of baggy eyelids plasty through posterior orbital septum fat displacement could reduce hemorrhage, prevent enophthalmos and decrease baggy eye palindromia, with better long-term effects.

Objective To investigate CT and MRI findings of rare cystic disease of the pancreas.Methods Elven cases with rare cystic disease of the pancreas underwent plain and contrast-enhanced CT and MR imaging before operation were reviewed.The clinical presentations and imaging findings were analysed.Among eleven cases,four were epidermoid,four were lymphepithelial cyst and three were lymphangioma.Results (1) Epidermoids located in the tail of the pancreas with smooth wall,the density of parenchyma of the lesons was the same as spleen at CT plain scan.On contrast-enhanced CT and MRI,the parenchyma of the lesions showed the same enhanced pattern with spleen.(2)Lymphepithelial cysts often occurred in olderly men.The lesions appeared as multilocular masses with definite border,isodensity at CT plain scan,and mixed iso-hyperintensity on both T_1WI and T_2WI images.After injection of contrast medium,the wall and septum of the lesions were enhanced.(3)Lymphangiomas were multilocular cystic lesion in the body-tail of the pancreas,hypodense at CT plain scan,and long T_1 and T_2 signal intensity at MRI plain scan.The septum and wall of the lesions were slightly enhanced on contrast-enhanced images.The lesions were not communicated with the pancreatic duct but pancreatic ducts were compressed and slightly shifted.Conclusion CT and MRI findings of rare neoplastic cystic disease of the pancreas are of certain characteristics.

SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries, however, the underlying mechanism, in particular immune responses in different organs, remains elusive. In this study, comprehensive transcriptomic alterations of 14 tissues from rhesus macaque infected with SARS-CoV-2 were analyzed. Compared to normal controls, SARS-CoV-2 infection resulted in dysregulation of genes involving diverse functions in various examined tissues/organs, with drastic transcriptomic changes in cerebral cortex and right ventricle. Intriguingly, cerebral cortex exhibited a hyperinflammatory state evidenced by significant upregulation of inflammation response-related genes. Meanwhile, expressions of coagulation, angiogenesis and fibrosis factors were also up-regulated in cerebral cortex. Based on our findings, neuropilin 1 (NRP1), a receptor of SARS-CoV-2, was significantly elevated in cerebral cortex post infection, accompanied by active immune response releasing inflammatory factors and signal transmission among tissues, which enhanced infection of the central nervous system (CNS) in a positive feedback way, leading to viral encephalitis. Overall, our study depicts a multi-tissue/organ transcriptomic landscapes of rhesus macaque with early infection of SARS-CoV-2, and provides important insights into the mechanistic basis for COVID-19-associated clinical complications.
Animals ; COVID-19/genetics* ; Macaca mulatta ; SARS-CoV-2/genetics* ; Transcriptome