Objective To investigate the scavenging effect of Baoyuan anticancer oral solution on superoxide anion (O-2 ) and 1,1-diphenyl-2-picrylhydrazyl hydrate(DPPH) free radicals. Methods O-2 and DPPH were examined with the ESR (electron spin resonance) spin trapping method. Results The scavenging effect of Baoyuan anticancer oral solution diluted to 50 fold, on O-2 and DPPH free radicals was 81. 32% and 98. 47% , respectively. Conclusion Baoyuan anticancer oral solu-tion has a dose-related effect on free radical elimination.

Accurate pre-operative evaluation of characteristics and various pathological subtypes of renal parenchymal tumors has important value for the choice of operation design as well as the assessment of prognosis.The advances of CT,MR and contrast-enhanced ultrasonography (CUES) in diagnosis of renal parenchymal tumors were reviewed in this article.

OBJECTIVE:To study the inhibition effects of tranilast on hypertrophic scar tissue of rabbits and its mechanism. METHODS:Rabbits were selected to induce hypertrophic scar(HS)model,the HS model rats were randomly divided into model control group (normal saline),tranilast low-dose,medium-dose,high-dose groups (0.3,0.5,0.7 mg/kg),6 rabbits in each group,local intradermaly injected corresponding drugs. Scar thickness 1 h before injection and the first,third,fifth week after in-jection in each group were measured,pathological changes of scar(fifth week after injection)were observed,transforming growth factor β1 (TGF-β1),α-smooth muscle actin(α-SMA)mRNA and protein expression were detected. RESULTS:Compared with 1 h before injection,scar thickness of rabbits in other groups were decreased after injection except for model control group. In fifth week after injection,compared with model control group,scar thickness of rabbits in other groups were decreased,pathological changes were improved;TGF-β1,α-SMA mRNA and protein expression were decreased (P<0.05),showing positive correlation with tranilast dose. CONCLUSIONS:Tranilast can inhibit the formation of hypertrophic scar,and the mechanism may be related to inhibiting the TGF-β1,α-SMA mRNA and protein expression.

Objective To explore the effect of human neural stem cells(hNSCs) transplantation to treat cerebral ischemic rats and the status of transplanted hNSCs in the ischemic brain tissue of these rats.Methods Human neural stem cells were separated from 10~13 weeks brains of human embryo and were cultured and induced to differentiate. The middle cerebral artery occlusion rat models were made and the human neural stem cells were transplanted through tail vein 1 day later. Neurological Severity Scores (NSS) tests were undertaken in two groups after transplantation. Immunohistochemistry was used to check the differentiation and migration of human neural stem cells in vitro and vivo.Results Neural stem cells from human embryonic brains had been successfully cultured. These cells formed typical neurospheres in suspension, and the majorities expressed nestin. Three weeks later, the neurological function of rats that received transplantation recovered much better than the rats without transplantation, as evidenced by NSS ( P

Objective To explore the effect of human umbilical cord blood cells (HUCBCs) transplantation to treat cerebral ischemia of rats and the status of transplanted HUCBCs in the ischemic brain tissue of these rats. Methods The mononuclearcells abstracted from 60～100 ml of cord blood of full-term babies were cultured in vitro and marked with 5-bromodeoxyuridine (Brdu)(5 ?mol/L) for 2 days. The middle cerebral artery occlusion rat models were made and the HUCBCs (3?106) were transplanted into the lateral ventricular 1 day later. Neurological severity scores (NSS) tests were undertaken at different time point after transplantation, and iimmunohistochemistry method was used to check the migration and differentiation of HUCBCs. Results The HUCBCs had the capacity of proliferation in vitro and were induced to differentiate into astrocytes, oligodendrocytes and neurons in vivo. 3 weeks later, the neurological function of rats that received transplantation recovered much better than the rats without transplantation, as evidenced by NSS (all P

Objective To investigate the proliferation of neural stem cells by subcutaneous injection of basic fibroblast growth factor(bFGF),epidermal growth factor (EGF)or combined bFGF and EGF respectively after transient focal cerebral ischemia in rats.Methods The right middle cerebral arteries(MCA) of rats were occluded for 2 h to establish transient focal cerebral ischemia model. bFGF, EGF,combined bFGF and EGF or vehicle were administered subcutaneously at 24, 48 and 72 h after MCA occlusion(MCAO).Thereafter,one administration every 3 d. Proliferating neural stem cells were labeled with bromodeoxyuridine (Brdu) immunohistochemically. Brdu-labeled cells were calculated to characterize neural stem cells in SVZ and the dentate gyrus of the hippocampus at 7 d,14 d,21 d after MCAO.Results Brdu-labeled cells were detected in the bilateral SVZ and the dentate gyrus of the hippocampus after MCAO in each group, the number of positive cells decreased progressively. Compared with the control group, the number of Brdu-labeled cells in treatment group increased significantly after treatment( P

Considering technology,regulations and other factors,nowadays we still use the records of print instead of in digital.《Electric Signature Law》makes a new environments for the study of electric medical records system.It regulates the writing,originally form and the save of electric medical records,affirms its value of evidence in court and prescribes what is dependable electric signature.

Objective: To explore the relationship between social support and internet addiction in undergraduates. Method: 382 undergraduates were divided into three groups according to their social support score and perceived social support score at end of the first term in their freshmen year. They were followed for 4.5 years to collect the incidence of internet addiction. Results: The group with less social support or less perceived social support had higher incidence rate (15.7%, 7.9% and 2.4% with social support score 0～60, 61～73 and higher than 73 respectively, ?2=9.49,P=0.009). There was obvious dose-effect relationship between social support and incidence of internet addiction. Conclusion: Less social support is a risk factor of internet addiction.

Objective:To screen the optimal base of compound titanium dioxide cream. Methods:Phenyl salicylate and titanium dioxide were respectively combined with 5 kinds of matrices to prepare compound titanium dioxide cream. The properties and stability of compound titanium dioxide cream were studied. Results:The 5 kinds of anionic emulsifiers all could be used to prepare compound titanium dioxide cream. The cream prepared with formula A was thick,and the cream prepared with formula B, C,D and E were delicate,luster and easy to smear. After the centrifugal test and low temperature test,the cream had no obvious changes. After the high temperature test,the cream prepared with formula A and B was dry and rough,the cream prepared with formula D had no significant changes when compared with that stored under room temperature,and the cream prepared with C and E was attenuated and changed into solution. Stored under the room temperature for 12 months,the cream prepared with formula D had no changes in the content and properties. Conclusion:Compound titanium dioxide cream prepared formula D is delicate and easy to smear with good stability,which shows good clinical application value.