Objective　To study the relationship between the biologic behaviours of gastric carcinoma (GC) and the immune reaction cells of GC tissue. Methods　One hundred and seven radical gastrectomy specimens and 3 to 8 years follow-up data were quantitatively assessed on the reactive degree of lymph-plasma cells and eosinophils with CMIAS image analysis system. Mast cell reaction was accounted in the low power microscopy. Each indicator was divided into two groups, high reaction group and low reaction group, according to the intensity of reactions. Both high reaction and low reaction group were analysed on the base of clinicopathologic parameters. Results　There was a significant difference in the survival time, depth of tumour invasion and lymph node metastasis in GC tissue between high reaction group and low reaction group (P<0.05). Conclusions　Local immune reaction cells plays an important role in the defense mechanism of GC host against the tumour cells invising and spreading.