Sunitinib (SU11248) is a novel orally administered small molecule that inhibits multiple receptor tyrosine kinases so that can block tumor growth and angiogenesis. It was approved on 2006, for the treatment of advanced renal cell carcinoma and gastrointestinal stromal tumor. Various cutaneous adverse reactions induced by sunitinib have been reported, including hand-foot syndrome. We report two cases of hand-foot syndrome induced by sunitinib for treatment of advanced renal cell carcinoma.
Carcinoma, Renal Cell ; Gastrointestinal Stromal Tumors ; Hand-Foot Syndrome ; Indoles ; Phosphotransferases ; Pyrroles ; Tyrosine

A 23-year-old man presented with two asymptomatic, yellowish papules surrounded with several whitish papules localized on the right cheek. Gross findings of the whitish lesions corresponded with milia. Histopathologic examinations of yellowish lesions revealed folded cyst walls consisting of several layers of epithelial cells, which were consistent with the diagnosis of steatocystoma. This case could be further proof steatocystoma and milia originate from the same pilosebaceous unit. It is important to differentiate steatocystoma from milia for less scarring after surgical treatment.
Cheek ; Cicatrix ; Epithelial Cells ; Humans ; Young Adult

A 29-year-old man presented with well-demarcated brown-to-erythematous patches with scales on the perioral and periocular areas. We could not find any other systemic signs and symptoms, except for the cutaneous findings and no abnormal results were found on laboratory tests. Histologic examination showed upper dermal granulomatous infiltrate and led us consider the diagnosis of granulomatous periorificial dermatitis. After daily taking oral minocycline 200 mg with application of topical tacrolimus ointment for 8 weeks, combined with the application of topical tacrolimus ointment, the lesion showed a marked improvement without scarring.
Adult ; Cicatrix ; Dermatitis ; Dermatitis, Perioral ; Humans ; Minocycline ; Tacrolimus ; Weights and Measures

Unilateral nevoid telangiectasia is characterized by unilateral occurrence of telangiectases assigned to certain dermatomes. Histologically, numerous thin-walled dilated vessels are seen in the upper and mid dermis without endothelial cell proliferation. Although it may be congenital or aquired, only acquired forms have been frequently reported in association with physiologic states of estrogen increase or estrogenized pathologic states, such as chronic hepatic disease in alcoholism. We report a case of congenital unilateral nevoid telangiectasia with extensive involvement of C4-T2, L1-S3 dermatomes in a 3-year-old girl.
Alcoholism ; Dermis ; Endothelial Cells ; Estrogens ; Preschool Child ; Telangiectasis

Chondroid syringoma is rare, benign tumor of the sweat gland. It clinically presents as intradermal or subcutaneous nodule on the head and neck, measuring 5 to 30 mm in diameter. Giant chondroid syringoma can be defined as chondroid syringoma that exceed 30 mm at the point of greatest diameter if it occurs on the head and neck area. Most chondroid syringomas on the head and neck do not exceed 30 mm in diameter. We herein, report a case of giant chondroid syringoma of the nose in an 87 year-old woman.
Adenoma, Pleomorphic ; Female ; Head ; Humans ; Neck ; Nose ; Sweat Glands

Parry-Romberg syndrome is an extremely rare connective tissue disorder. It might be a form of linear scleroderma, and it manifests as progressive hemifacial atrophy, epilepsy, exophthalmos or alopecia. Herein we report a case of Parry-Romberg syndrome. A 68-year-old woman had left hemifacial atrophy, shortening and deformity of the left leg, and deformities to her side fingers that occurred from her 1st decade to 2nd decade. Sclerotic change had stopped spontaneously when she was 20 years old. Histopathologically, there were a few signs of skin appendages, but no sclerotic change. On autoimmune antibody test, no positivity was shown. X-ray showed shrinkage of the lung field, elevation of the left diaphragm, shortening of length and reduction of bone mass in the left femur, tibia, and fibula. And there were multiple melorheostasis. Neck CT showed left facial sclerotic change, bone mass loss, and multiple melorheostasis. Because the progression of sclerosis had stopped the patient did not receive any treatment.
Aged ; Alopecia ; Congenital Abnormalities ; Connective Tissue ; Diaphragm ; Epilepsy ; Exophthalmos ; Facial Hemiatrophy ; Female ; Femur ; Fibula ; Fingers ; Humans ; Leg ; Lower Extremity ; Lung ; Neck ; Scleroderma, Localized ; Sclerosis ; Skin ; Tibia

Zoster sine herpete (ZSH) is difficult to diagnosis during an acute period due to the absence of the characteristic zosteriform dermatomal rash; therefore, progression to postherpetic neuralgia is more common than typical zoster. In addition, misdiagnosis of other neuropathic pain as ZSH is common in clinical situations. Here, we report a case of spinal arteriovenous malformation that mimics ZSH. This is a rare condition; therefore, high clinical suspicion for a correct diagnosis and proper examination are not easy. However, early diagnosis and definitive treatment are essential to prevent neurologic deficit and mortality.
Arteriovenous Malformations ; Diagnostic Errors ; Early Diagnosis ; Herpes Zoster ; Neuralgia ; Neuralgia, Postherpetic ; Neurologic Manifestations ; Zoster Sine Herpete

More than 80% of cancer patients experience cancer pain. Among them, more than 50% experience moderate to severe pain. To control cancer pain, a variety of methods have been used, including medications and nerve blocks. In some patients, however, it is impossible to perform nerve blocks due to caner metastasis into the epidural space, while in other patients, opioid dose escalation is impossible due to opioid side effects; thus, cancer pain management is difficult. Scrambler therapy is a novel approach for pain control that uses EKG-like pads, which are applied above and below the site of pain. Scrambler therapy synthesizes 16 different types of nerve action potentials that provide "non-pain" information via cutaneous nerves. The advantages of this treatment are that it is non-invasive and safe and has no significant side effects. In this case series, we report the treatment results of using scrambler therapy in three cancer patients with intractable pain.
Action Potentials ; Epidural Space ; Humans ; Neoplasm Metastasis ; Nerve Block ; Pain Management ; Pain, Intractable

Hemifacial spasm is defined as unilateral, involuntary, irregular twitching of all or parts of the muscles innervated by facial nerves. Here, we present a case of recurrent hemifacial spasm after microvascular decompression (MVD) treated with pulsed radiofrequency (PRF) treatment with good results. A 35-year-old woman suffered from recurrent hemifacial spasm after MVD that was refractory to medical treatment and botulinum toxin injections. We attempted a left facial nerve block twice. Then, we applied PRF at a maximum temperature of 42degrees C for 120 sec. Some response was observed, so we applied PRF two additional times. The frequency of twitch decreased from 3-4 Hz to < 0.5 Hz, and subjective severity on a visual analogue scale also decreased from 10/10 to 2-3/10. PRF treatment might be an effective medical treatment for refractory hemifacial spasm and has fewer complications and is less invasive compared with those of surgery.
Botulinum Toxins ; Facial Nerve ; Female ; Hemifacial Spasm ; Humans ; Microvascular Decompression Surgery ; Muscles ; Pulsed Radiofrequency Treatment

BACKGROUND: Olfactory dysfunction, including anosmia and hyposmia is difficult to treat. Although the mechanism is not well known, stellate ganglion block (SGB) is used to treat olfactory dysfunction. There are no prior studies on the long-term effects of SGB on olfactory dysfunction. The purpose of this study was to evaluate the continuity of therapeutic effects and patient satisfaction with SGB treatment. METHODS: This was a follow-up study carried out via a telephonic survey. The olfactory function of the patient was evaluated using a visual analog scale (VAS). We checked VAS three times: VAS-I (pre-treatment VAS), VAS-A (post-treatment VAS), and VAS-C (VAS at follow up telephone survey). We divided the subjects into 2 groups according to their responsiveness to SGB: the responsive (R group) and the unresponsive groups (UR group). Patient satisfaction was evaluated using a Likert scale. RESULTS: Out of the 40 subjects, 37 responded to the telephone survey. In the UR group, there was difference in the olfactory function. However, in the R group, there were significant VAS differences; VAS-I was 9.6 +/- 0.7, VAS-A was 5.1 +/- 4.2, and VAS-C was 2.7 +/- 2.7 (P < 0.05). On the Likert scale, patient satisfaction was as follows: grade 1, 17 patients (45.9%); grade 2, 6 patients (16.2%); grade 3, 6 patients (16.2%); and grade 4, 8 patients (21.6%). CONCLUSIONS: SGB is a safe, long-lasting, and effective therapeutic modality for olfactory dysfunction treatment.
Arginine Vasopressin ; Follow-Up Studies ; Humans ; Olfaction Disorders ; Patient Satisfaction ; Smell ; Stellate Ganglion ; Telephone