Objective To investigate the application of xingnaojing injections ( XNJI) in inpatients and further provide a reference for the rational drug use. Methods The retrospective investigation was carried out by reviewing 186 hospitalization records with XNJI from a certain hospital from January 2014 to June 2015. The usage, dosage, and indication of XNJI were analyzed. Results Unlabeled use of XNJI was found in the neurology department inpatients. 59. 7% inpatients were treated with overdosed XNJI, and 13. 4% were treated with a single drug dose of 40 mL. The inappropriate solvent selection accounted for 49. 5%. Compatibility of XNJI and western medicine injection accounted for 54. 8%. It was also found that XNJI was used together with potassium chloride in clinic (47. 8%). Conclusion There exist some irrational uses of XNJI in clinic, thus the use and management of traditional Chinese medicine injections should be standarized.

When seen from the practice and development of modern medicine,we are facing challenges from various ethical problems which arise from the progress of life support technique,industry and network technique and its application in medicine,life sciences and electronic sciences.Nowadays,the legislation of medical ethics and regulations have become a heated issue drawing the attention of doctors,pharmacists,laboratorians,nurses,medical information staff,religions personnel,philosophers,medical scientists,and lawyers.This thesis tries to analyses the main ethical problems in the use of medical information so as to justify potential eligible ethical norms in clinical practice,expecting to draw the attention of relevant staff and general public and the fulfillment of ethical norms in the medical practice.

Animals ; Antioxidants ; metabolism ; Diabetes Mellitus, Experimental ; metabolism ; Melatonin ; metabolism ; Physical Conditioning, Animal ; Rats

OBJECTIVE: The aim of this study was to investigate the association of JAK1 polymorphisms with allergic rhinitis in China Han population. METHOD: A total of 450 patients with AR and 615 healthy subjects as control were genotyped for the presence of three single nucleotide polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PGR-RFLP) analysis of DNA extracted from blood samples. RESULT: All control subjects were in Hardy-Weinberg equilibrium, but high frequencies of JAK1 the homozygous rs310241 CC genotype were observed in AR patients compared to controls (P < 0.05). The results also revealed that there was no association between the rest of two investigated SNPs and AR. CONCLUSION Our results suggested that JAK1 gene rs310241 CC genotype was associated with patients with AR.
Asian Continental Ancestry Group ; genetics ; China ; Genetic Predisposition to Disease ; Genotype ; Humans ; Janus Kinase 1 ; genetics ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Rhinitis, Allergic ; genetics

OBJECTIVE: To determine whether chronic alcoholism alters the expression levels of Vasoactive intestinal polypeptide (VIP) and its receptor (VIPR1) in the cochlea of chronic alcoholism rats. METHOD: We measured their expression levels in 30 SD rats, in which we created models of different degrees of chronic alcoholism. We investigated the presence of the mRNA of VIP in the cochlea of chronic alcoholism rats and controls by reverse transcription-polymerase chain reaction (RT-PCR) method. We investigated the presence of proteins of VIPR1 in poisoned rats and controls by western blot. We also evaluated the local distribution of VIP cells by immunohistochemistry. RESULT: We found that the levels of VIP and VIPR1 were downregulated in the chronic alcoholism groups compared to the controls group. The differences in some expression levels were significant different between chronic alcoholism rats and control rats. Moreover, at different degrees of alcohol poisoning in rats, the contents of VIP and VIPR1 differed. Decreased levels of VIP and VIPR1 were detected in the deep chronic alcoholism group compared to the group with low-degree poisoning (P < 0.05). In spiral ganglion cell plasm the expression of VIP and VIPR1 had no significant difference in three groups (P > 0.05). CONCLUSION These results suggest that VIP and VIPR1 play an important role in the auditory function in rats with chronic alcoholism. Chronic alcoholism may cause a peptide hormone secretion imbalance in the auditory system, eventually leading to hearing loss.
Alcoholism ; metabolism ; Animals ; Cochlea ; metabolism ; Disease Models, Animal ; Down-Regulation ; RNA, Messenger ; Rats ; Rats, Sprague-Dawley ; Receptors, Vasoactive Intestinal Polypeptide, Type I ; metabolism ; Spiral Ganglion ; Vasoactive Intestinal Peptide ; metabolism

Humans ; Infant, Newborn ; Infant, Newborn, Diseases ; Lung Diseases ; Point-of-Care Systems ; Ultrasonography

Objective To explore the best sampling position of bone marrow biopsy in mice.Methods Mice were sacrificed by cervical dislocation, then take the skull, sternum, tibial, femoral and iliac bone, making pathological section.Observed and photographed under light microscope. Comparison of the distribution of the essence and the hematopoietic microenvironment in different parts.Select site which can best reflect the hematopoietic function of bone marrow.Results A large number of hematopoietic cells in ilium marrow sections visible.The cells are evenly distributed. Blood and megakaryocytes were clearly visible.The arrangement of the structure of the scaffolds for tissue closely.The number of fat cells less.Bone marrow hematopoietic cells in the skull, sternum, tibial, femoral were not clear and not active.And there are more fat cells.Conclusions As the best sampling position of bone marrow biopsy, is ilium.

Objective To observe the protective effect of Danggui Buxue Decoction on 60 Co-γray irradiated mice. Methods The experimental mice were randomly divided into 5 groups ( the normal control group , model group , Danggui Buxue Decoction of low , middle and high dose groups ) .The mouse except the normal control group were irradiated by 60Co-γray and established the radiation-damage model.Peripheral blood neutrophil count (NEUT), the number of bone marrow nucleated cells ( BMC ) , the activity of serum superoxide dismutase ( SOD ) and the serum levels of malondialdehyde ( MDA) were measured .Results Radiation injury in mice of NEUT , BMC and SOD were significantly decreased (P <0.01), MDA were increased (P <0.01).Danggui Buxue Decoction can increase the levels of NEUT , BMC and SOD in mice after radiation injury , decrease the content of MDA .And protective effect of high dose group was better (P <0.01).Conclusions Danggui Buxue Decoction has protective effect on radiation injury in mice .And there is a correlation between the protection effect and dose .

Humans ; Percutaneous Coronary Intervention ; Propensity Score