Cardiovascular disease(CVD) is a common fingding in paitients with chronic renal failure(CRF),its pathogenesis is not clear.In the past decade,the relation reduce of EPO,malnutrition and inflammation,endothelial dysfunctin and angiodysplasia with pathogenesis of CVD had been investigated,These risk factors inducing CVD were reviewed.

The role of the microvascular disease in progressive renal disease is not well understood .This review presents evidence that progressive renal disease is characterized by a progressive lose of the microvasulature. And presents the factors that induce the lose of the microvasculature. Try to find out (agents) which may represent a novel therpeatic approach for slowing the renal disease.

The objective of this article was to explore new channels of information transmission in public health emergencies.According to the requestments of information transmission in public health emergencies,the current situation and problems were analysed.To solve the problems,the authors put forward a number of constructive measures,and came to the conclusion that to strengthen the construction of the channels of information transmission is one of the fundamental ways of improving the efficiency of correct handling of public health emergencies.

β-Glucan is a kind of highly conservative composition on fungal cell wall.As a recognition receptor of β-glucan,dendriticcell-associatedC-typelectin-1 (dectin-1)widely distributeinsingle-nuclea macrophages system,dendritic cells ( DC )and neutrophil cells.Through the identification of fungal cell wall composition and cells signal transduction,dectin-1 induces the production of cytokine and chemokine and then starts a nonspecific and specific immunity response.Dectin-1 plays a key role in antifungal immune response.Here,the molecular structure,tissue cells,signal transmission and the immune inflammation role of dectin-1 in corneal infection were reviewed.

Objective To explore the effect of c-Jun NH2-terminal kinase(JNK)signal transduction pathway on hyperoxia-induced lung injury in rats.Methods Twenty-four Wistar rats aged 3 weeks were randomly divided into 3 groups(n=8):room-air control group,7 d hyperoxia exposure group,and 7 d hyperoxia exposure with inhibitor of JNK intervention group.The rats in hyperoxia exposure group were exposed to high concentration of oxygen [fractional concentration of inspired oxygen(FiO2)≥950 mL?L-1] at normal pressure.The rats in room-air control group were placed in room air(FiO2=210 mL?L-1)at normal pressure.The rats in JNK inhibitor intervention group were intraperitoneally injected 30 mg?kg-1 SP600125 and exposed to hyperoxia 2 h later.The histopathological changes of lung tissues were observed by means of light microscope,therefore the changes of lung W/D weight ratio,total protein in bronchoalveolar lavage fluid(BALF)and lung permeation index were detected.The extent of lung cells apoptosis was analyzed by terminal deoxynucleotidyltrans-ferase-mediated dUTP nick end labeling assay.The protein level of p-JNK was measured by Western blotting analysis.Results Compared with room-air control group,conspicuous hyperaemia,edema,hemorrhage and extensive inflammation cells infiltration in the lung tissues were significantly observed in 7 d hyperoxia exposure group.The lung W/D weight ratio,total protein in BALF,lung permeation index,cell apoptotic index and the p-JNK protein levels of lung tissues all significantly increased in 7 d hyperoxia exposure group compared with those in room-air control group(Pa

BACKGROUND:The essence of cell differentiation is a selectively intra-cellular gene expression,which results in specific proteinic synthesis and causes changes in biochemistry,structure and function.Thus,original proteomics and a single protein analysis can not meet the requirement in study.Proteomics technology provides a powerful tool due to the large scale,systemical study of protein transformation and interaction,which can be used for exploring molecular mechanism of bone mesenchymal stem cells(BMSCs)during directional differentiation.OBJECTIVE:To introduce proteomics,to summarize the research of proteomics in directional differentiation of BMSCs,and to forecast the development of proteomics research methods.METHODS:To search articles highly related with BMSCs,cell differentiation,and proteomics published on CNKI (www.cnki.net/index.htm),Sciencedirect(http://www.Sciencedirect.com),I.S.I(http://www.isiwebofknowledge.com)were searched,and the key achievements were included in the analysis.RESULTS AND CONCLUSION:A total of 29 documents were reviewed,and the experiences in the application of proteomics technology in the directional differentiation of BMSCs were summarized.With the innovation and development in methodology and technology,proteomics will become a powerful tool for us to study the potential mechanisms of BMSCs directional differentiation.

Aptamers are short nucleic acids or peptides that strongly bind to a protein of interest and functionally inhibit a given target protein at the intracellular level. Besides high affinity and specificity, aptamers have several advantages over traditional antibodies. Hence, they have been broadly selected to develop antiviral agents for therapeutic applications against hepatitis B and C viruses (HBV, HCV). This review provides a summary of in vitro selection and characterization of aptamers against viral hepatitis, which is of practical significance in drug discovery.

Objective To investigate recurrence of colorectal adenoma (CRA)after polypectomies and colonoscopic surveillance,and to explore risk factors related to CRA recurrence.MethodsFrom June 2005 to December 2009,in the Fist Affiliated Hospital of Anhui Medical University,the clinical data of 283 hospitalized patients who underwent CRA polypectomy and met the study criteria were collected and followed up.The recurrence rate of CRA after polypectomies,the relationship between colonoscopic surveillance interval and CRA recurrence and risk factors related to recurrence were analyzed.The colonoscopic surveillance interval,frequency and the reason for no colonoscopic surveillance were also analyzed.ResultsA total of 235 post-polypectomies CRA patients were successfully followed up,the follow-up rate was 83.0％ (235/283).The shortest follow-up period was 12 months and the longest was 66 months,the median follow-up time was (35.1 ± 14.2)months.A total of 115 patients were underwent colonoscopic surveillances,the surveillance rate was 49.4％ (115/233).The recurrence rate was 45.0％ (50/111) in colonoscopic surveillance group.A total of 118 patients were without colonoscopic surveillances.Age over 60 years,body mass index over 25 kg/m2 and multiple adenomas (≥ 2) were significantly related with CRA recurrence,and the difference was statistical significant (P＜ 0.05).The rate of awareness that CRA needed regular surveillance group without surveillonce was significantly lower than that of group with surveillance.(P＜0.01).ConclusionThe recurrence rate of CRA after polypectomies is high.Age,high body mass index and multiple adenomas are predicted independent risk factors for CRA recurrence.Lacking awareness of the importance of regular surveillances after polypectomies is the main reason for low colonoscopic surveillance rate after polypectomies in our hospital.

Nerve growth factor, a kind of neurotrophic factor, plays an important role in neuronal development, differentiation, survival and neurogenesis, and is considered as a link between neuroendocrine system and immune system in asthma attack. The possible mechanism of effects of nerve growth factor on asthma is as follows: (1) nerve growth factor changes airway innervation, and facilitates the synthesis and release of neurotransmitter in nerve terminal, which will contribute to airway remodeling; (2) nerve growth factor induces eosinophils aggregation, proliferation and releasing inflammatory factor, which will lead to the abnormality of immunologic response; (3) nerve growth factor triggers the redundancy of adrenal medullary cells, which results in adrenal medullary cell to nerve cell transition, and then the impairment of chromaffin cell endocrine secretion function. As a result, the concentrations of adrenaline in circulation are not competent to relieve the bronchoconstriction in asthmatic attack.

As the subject of educational scientific research work,teachers are the first driving force of curriculum reform and specialty building in school.The deployment and quality of teachers are closely related to scientific research achievement.In order to ascertain their relationship the situation of articles published papers and scientific projects have been analysed combined with the age professional titles and educational background of teachers in our college,which may provide preferences for the sustainable development of the school.